1,721,636 research outputs found
Italian multicenter study on preservatives sensitization.
No full textan epidemiologic study on preservatives contact dermatitis is reporte
Treatment of common nail disorders
No full textTreatment of nail diseases is not always easy, because topical treatment is often ineffective as the nail plate is not penetrated by topical drugs and the nail matrix is located under the proximal nail fold. The most frequent nail disorders are nail psoriasis and onychomycosis. In these cases systemic treatment is often necessary to cure the nail changes. Systemic treatment with steroids is mandatory for patients with nail lichen planus, because the disease may cause definitive destruction of the nail matrix. Environmental nail abnormalities are very frequent and include nail brittleness, onycholysis, and chronic paronychia. Preventive measures should always be associated with treatment in these cases
Drug-induced nail disorders. Incidence, management and prognosis
No full textA large number of drugs of different classes, ranging from antibacterials to chemotherapeutic agents to psoralens, can be responsible for the development of nail changes. Drug-induced nail changes usually involve several or all 20 nails and appear in temporal correlation with drug intake. Some nail changes are asymptomatic and only cause cosmetic problems, while others cause pain and discomfort and impair manual activities or deambulation. Drug-induced nail abnormalities are usually transitory and disappear with drug withdrawal, but sometimes persist in time. The pathogenesis of the nail changes is usually a toxic effect of the drug on the different nail constituents, but other mechanisms can be involved. Drugs that are well known to produce trail abnormalities include cancer chemotherapeutic agents, psoralens, retinoids, tetracyclines, antimalarials and zidovudine. Arsenic poisoning is also always associated with nail changes that have medico-legal importance. Some drugs taken during pregnancy may impair nail development of the fetus, and nail hypoplasia or other nail dystrophies will be evident in the newborn
Traumatic nail abnormalities
No full textThe nail plate is frequently affected by traumatisms that can be post-traumatic, occupational or self-induced. Among the self-induced nail disorders a psychiatric counselling must be sometimes considered. These include the "median dystrophy", the "Heller's canaliform dystrophy", the "onychophagy" and the "onychotillomania". The post-traumatic onychodystrophies include traumas of the pterigium, subungual haematomas, "melanonychia striata", "ingrown nail", "pincer nail" and "onychogriphosis". Lastly, there are occupational onychodystrophies, including "onychoschizia" or "brittle nails", "koilonychia", "chronic paronichia" and "onycholysis"
Proximal subungual onychomycosis due to Aspergillus niger: report of two cases
No full textNo abstract availabl
Warts of the nail unit: surgical and nonsurgical approaches
No full textBackground: Warts are the most common nail tumor and mostly affect children and young adults. Periungual warts are usually due to HPV-1, 2, and 4. Development of periungual warts is favored by maceration and trauma, especially nail biting. Objective: To discuss the biology, clinical features, and medical and surgical treatment of periungual warts. Methods: Review of the literature and personal experience. Results: The natural course of warts makes aggressive approaches restricted to selected cases. Medical treatments, usually topical, include keratolytic agents, virucidal agents, and immunomodulators. All choices have been utilized successfully, but keratolytic agents are the best first-line approach. Surgical treatments include cryotherapy, surgical excision, electrosurgery, infrared coagulation, localized heating with a radio-frequency heat generator and laser therapy, especially the Er:YAG laser, which has an excellent safety profile. Conclusions: Definitive cure is not guaranteed by any therapy and periungual warts can recur and become larger after correct treatment
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