3,608 research outputs found
ALT-C 2011 Abstracts
No full textThis is a PDF of the abstracts for all the sessions at the 2011 ALT conference. It is designed to be used alongside the online version of the conference programme. It was made public on 1 September, with a "topped and tailed" made live on 2 September
[Rezension zu:] Torsten Riotte, Der Monarch im Exil. Eine andere Geschichte von Staatswerdung und Legitimismus im 19. Jahrhundert, Göttingen (Wallstein) 2018, 427 S., 13 Abb. (Veröffentlichungen der Historischen Kommission für Niedersachsen und Bremen, 295), ISBN 978-3-8353-3058-0, EUR 39,90
No full textObwohl das Interesse an der Erforschung der Monarchie so alt ist wie die Geschichtswissenschaften selbst, bestand in der Untersuchung der Begebenheiten nach dem Sturz eines Monarchen bisher eine weitgehende Forschungslücke. Nachdem er das Thema in einem mit Philip Mansel 2011 herausgegebenen Sammelband bereits angeschnitten hatte, legt Torsten Riotte mit seiner Habilitationsschrift nun eine erste komparative und umfassende Studie des modernen monarchischen Exils vor. Riotte widmet sich dabei mit großer Sorgfalt zwei Fallstudien: dem Comte de Chambord, Prinz Henri d’Artois (1820–1883), der Frankreich nach der Revolution von 1830 noch als Kind verlassen musste, und dem Herzog von Cumberland, Prinz Ernst August von Hannover (1845–1923), der seinem Vater dem König 1866, nach der Annexion Hannovers durch preußische Truppen, ins Exil folgte. Beide fanden Zuflucht in Österreich und ließen sich dauerhaft in der Nähe Wiens nieder. ..
Mit Panzer lebt sich’s länger
No full textÜBERLEBENSKÜNSTLER ⋅ Grosse Schildkröten werden nicht nur sehr alt, sondern haben auch schon 250 Millionen Jahre und damit alle Massensterben überlebt. Der Paläontologe Torsten Scheyer erforscht sie bis auf die Knochen
Alt-X turns 10: unclassifiable writing triumphs
No full textDarren Tofts interviews American artist and author Mark Amerik
Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood
No full textPurpose: Elongation of telomeres is necessary for tumor cell immortalization and senescence escape; neoplastic cells use to
alternative pathways to elongate telomeres: telomerase reactivation or a telomerase-independent mechanism termed alternative
lengthening of telomeres (ALT). Telomerase and ALT pathway has been explored in adult and pediatric gliomas and
medulloblastomas (MDBs); however, these mechanisms were not previously investigated in MDBs metastatic at the onset.
Therefore, we analyzed the activation of telomerase and ALT pathway in a homogenous cohort of 43 pediatric metastatic
medulloblastomas, to investigate whether telomere elongation could play a role in the biology of metastatic MDB.
Methods: We evaluated telomeres length via telomere-specific fluorescence in situ hybridization (Telo-FISH); we assessed
nuclear expression of ATRX by immunohistochemistry (IHC). H3F3A and TERT promoter mutations were analyzed by
pyrosequencing, while UTSS methylation status was analyzed via methylation-specific-PCR (MS-PCR).
Results: H3F3A mutations were absent in all MDBs, 30% of samples showed ATRX nuclear loss, 18.2% of cases were
characterized by TERT promoter mutations, while 60.9% harboured TERT promoter hyper-methylation in the UTSS region.
Elongation of telomeres was found in 42.8% of cases. Metastatic MDBs control telomere elongation via telomerase activation
(10.7%), induced by TERT promoter mutations in association with UTSS hyper-methylation, and ALT mechanism
(32.1%), triggered by ATRX inactivation. Among non-metastatic MDBs, only 5.9% (1/17) showed ATRX nuclear loss with
activation of ALT.
Conclusions: Our metastatic cases frequently activate ALT pathway, suggesting that it is a common process for senescence
escape in primary metastatic medulloblastomas. Furthermore, the activation of mechanisms for telomere elongation is not
restricted to certain molecular subgroups in this high-risk group of MDBs
MEDB-68. Analysis of telomeres length and Alternative Lengthening of Telomeres (ALT) in molecular subgroups of infant medulloblastoma
No full textWe investigated the association between the molecular profile and telomere length in a infant medulloblastoma (iMB) cohort, retrospectively studied. Activation of telomeres maintenance mechanisms was analyzed to determine whether the senescence escape triggered by telomere-elongation mechanisms could explain the aggressivity of some iMB belonging to the same molecular subgroup. Interestingly, several telomerase- and ALT-targeted therapies have recently been tested on pediatric cancers and might represent a promising strategy for the future treatment of aggressive telomerase- or ALT-positive iMB. We analyzed a cohort of 50 FFPE tissues from young MB patients (age ≤ 3); IHC, FISH, and an Illumina 850K methylation profile were used to identify molecular subgroups. Telomere length was measured using Telo-quantitative FISH, and image analysis was performed using TFL-Telo software. Three distinct telomere intensity categories (low (L), medium (M), and high (H)) were identified by comparing neoplastic- to endothelial-cell signals in each sample. ATRX loss and TERTp mutation/methylation were investigated using IHC and Sanger sequencing/methylation-specific PCR. SHH-MBs accounted for 59% of our cohort, while Group3/4-MBs accounted for 41%; no WNT-MBs were detected. ALT was found to be activated in 10% of iMBs and was not exclusive to any molecular subgroup, implying that it could be a potential mechanism associated with aggressive behaviour in a subset of iMBs. Promising results have been found in the telomere length distribution among the iMB molecular subgroups: SHH iMBs had a higher frequency of High (H) telomeres length (85%) than NON-SHH/NON-WNT iMBs (p=0.046), which were more frequently associated with Medium (M) telomeres length. CONCLUSIONS: ALT activation in infant MBs (10%) could be a novel target for risk-stratification and personalized therapy. It may be useful to examine ALT as a potential predictor of aggressive behaviour and as a promising novel therapeutic approach for a subset of these tumors in the diagnostic workup
Alt-right
No full textThis study examines the far right movement, Alt-right, who have transformed from an internet-niche to a movement with political influence in the last couple of years. The study analyses their use of symbols through semiotic theories by Charles Sanders Peirce, Søren Kjørup and Roland Barthes. It compares the methodology of the book The Authoritarian Personality from 1950 with the 2017 study A Psychological Profile of the Alt-right to determine which methods are needed to understand the movement. It concludes that the Alt-right movement are using a mix of already existing symbols and signs, in order to obscure their political agenda by changing the conventions behind the signs. The study finally concludes that the behaviour and attitude of the members of the Alt-right, can be mapped by using direct questions instead of ones that appeal to the unconscious mind
On the Benthic Invertebrate Megafauna at the Mid-Atlantic Ridge, in the Vicinity of the Charlie-Gibbs Fracture Zone
No full textLittle is known about the fauna that inhabits non-chemosynthetic environments associated with mid-ocean ridges. This thesis investigates a ridge and fracture zone system to assess its influence as a barrier to faunal dispersal, and as a unique bathyal habitat. It also describes the ecology of megabenthic communities inhabiting a ridge. Sites were chosen on the Mid-Atlantic Ridge in the vicinity of the Charlie-Gibbs Fracture Zone, at a target depth of 2,500 m. Four superstations were chosen north and south of the Fracture Zone, on either side of the ridge. Different productivity levels and hydrographic features were characteristic for the northern and southern sites. In order to characterise the benthic megafauna 50 ha were trawled and 32,000 m2 of seafloor were sampled with HD video footage, targeting both flat and 10 ? sloped habitats. Holothurians were the most abundant megafauna. In order to assess their evolutionary relationship 43 holothurian specimens were genetically studied by modelling five of their genes (16S, 18S, 28S, COI, H3) in a phylogenetic analysis. All four sites exhibited noticeably different faunal characteristics. The biomass was highest at the SE, and lowest at the NW site. Body sizes differed between sites for most taxa, that were sufficient in numbers to be compared between sites, most likely as a result of different adaptations to food supply. Differences in species richness were observed between the sampling methods, with the highest richness at the SE site in trawl samples, and highest at the NW and SW sites in the video survey. Species densities were highest at the northern sites with both methods. Differences in diversity were also observed, with trawl samples providing a higher taxonomic resolution than the video survey and showing highest diversity at the SE site and lowest at the NE site. Community composition was significantly different between sites. Variations in the composition of megabenthic assemblages were observed between flat and 10 ? sloped habitats, although the effect of slope appears to be site dependent. The genetic analyses revealed a close relationship between individuals from different families. The extent to which the Ridge acts as a faunal barrier was unclear as the southern sites lacked an obvious difference in community composition. Faunal differences to the north and south of the Fracture Zone, however, suggest that this feature is a barrier to dispersal. The contrasting megafaunal assemblages of the sites probably reflect a combination of environmental drivers including sediment type, phytodetrital quality, hydrography, and habitat complexity
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