841 research outputs found
The production of polyphonic manuscripts in thirteenth-century Paris: new evidence for standardised procedures
No full textModern understanding of the production and dissemination of thirteenth-century polyphony is constrained by the paucity of manuscript sources that have been preserved in their entirety; the panorama of sources of medieval polyphony is essentially fragmentary. Some of the surviving fragments, however, were torn from lost books of polyphony that were to some extent comparable to well-known extant codices. The fragment of polyphony preserved in the binding of manuscript 6528 of the Biblioteca Nacional de Madrid is illustrative in this respect. This fragment displays a number of codicological and musical features that are strikingly similar to those of the Florence manuscript (F). Both sources share format and mise-en-page, make use of similar styles of script, notation and pen-work decoration,We wish to thank Mark Everist, Carmen Julia Gutiérrez and the anonymous reviewers of Early Music History for their invaluable comments and suggestions. Permission to reproduce the images has been graciously accorded by the Biblioteca Nacional de España (BNE) and Ministero dei Beni e delle Attività Culturali e del Turismo (MiBACT). The following library sigla are used: CH-SGs Sankt Gallen, Stiftsbibliothek D-GI Giessen, Universitätsbibliothek E-Mn Madrid, Biblioteca Nacional de España F-Pn Paris, Bibliothèque nationale de France GB-Lbl London, British Library In addition, the Ars antiqua manuscripts mentioned in this article are indicated by their familiar sigla: F Florence, Biblioteca Medicea Laurenziana, Pluteus 29.1 LoA London, British Library, Egerton 2615Ma Madrid, Biblioteca Nacional de España, 20486 W1 Wolfenbüttel, Herzog August Bibliothek, Cod. Guelf. 628 Helmst. transmit the pieces in the same order, and present virtually identical musical readings. The Madrid fragment thus provides new evidence for a standardised production of polyphonic books in thirteenth-century Paris. The study provides a detailed account of the fragment's codicological and philological features, and explores the hypothesis that it originated in the same Parisian workshop that produced F.</p
Dinàmica de la utilitzacio de la cova per l'home en els darrers 6000 anys. Publication collective de : bibiana Agusti Farges, Gabriel Alcade Gurt, Francesc Burjachs Casas, Ramon Buxo Capde Villa, Nuria Juan-Muns Plans, Joan Oiler Guino, Maria Teresa Ros mora, Josep Manuel Rueda Torres, Assumpcio Toledo Mur, et d'autres collaborateurs.
No full textRenault-Miskovsky Josette. Dinàmica de la utilitzacio de la cova per l'home en els darrers 6000 anys. Publication collective de : bibiana Agusti Farges, Gabriel Alcade Gurt, Francesc Burjachs Casas, Ramon Buxo Capde Villa, Nuria Juan-Muns Plans, Joan Oiler Guino, Maria Teresa Ros mora, Josep Manuel Rueda Torres, Assumpcio Toledo Mur, et d'autres collaborateurs. In: Bulletin de l'Association française pour l'étude du quaternaire, vol. 25, n°1, 1988. p. 45
Author Correction: Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium
No full textCorrection to: npj Vaccines (2024) 9:53; https://doi.org/10.1038/s41541-024-00838-8, published online 06 March 2024 http://hdl.handle.net/10261/353891
1 Pág.In this article, the author name Núria López-Bigas was incorrectly written as Nuria López-Vigas. The original article has been corrected.Peer reviewe
Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment
No full textDemència; Mal de cap; IctusDemencia; Dolor de cabeza; IctusDementia; Headache; StrokeCADASIL is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the EGF-like repeat domain, causing protein misfolding and aggregation. The main symptoms are migraine, psychiatric disturbances, recurrent strokes and dementia, being executive function characteristically impaired. The molecular pathways altered by this receptor aggregation need to be studied further. A genome-wide transcriptome study (four cases paired with three healthy siblings) was carried out, in addition to a qRT-PCR for validation purposes (ten new cases and eight new controls). To study the expression profile by cell type of the significant mRNAs found, we performed an in situ hybridization (ISH) (nine cases and eight controls) and a research in the Single-nuclei Brain RNA-seq expression browser (SNBREB). Pathway analysis enrichment was carried out with Gene Ontology and Reactome. Neuropsychological tests were performed in five of the qRT-PCR cases. The two most significant differentially expressed mRNAs (BANP, p-value = 7.23 × 10–4 and PDCD6IP, p-value = 8.36 × 10–4) were selected for the validation study by qRT-PCR. Additionally, we selected two more mRNAs (CAMK2G, p-value = 4.52 × 10–3 and E2F4, p-value = 4.77 × 10–3) due to their association with ischemic neuronal death. E2F4 showed differential expression in the genome-wide transcriptome study and in the qRT-PCR (p = 1.23 × 10–3), and it was upregulated in CADASIL cases. Furthermore, higher E2F4 expression was associated with worse executive function (p = 2.04 × 10–2) and attention and information processing speed (IPS) (p = 8.73 × 10–2). In situ hibridization showed E2F4 expression in endothelial and vascular smooth vessel cells. In silico studies indicated that E2F4 is also expressed in brain endothelial cells. Among the most significant pathways analyzed, there was an enrichment of vascular development, cell adhesion and vesicular machinery terms and autophagy process. E2F4 is more highly expressed in the skin biopsy of CADASIL patients compared to controls, and its expression is present in endothelial cells and VSMCs. Further studies are needed to understand whether E2F4 could be useful as a biomarker, to monitor the disease or be used as a therapeutic target.This work was supported by a grant from the Carlos III Health Institute (PI 11/0176), Generación Project, Maestro Project, INVICTUS + network, Epigenesis Project (Marató de TV3), FEDER funds and economic donations from “Asociación CADASIL España”. E. Muiño is supported by a Río Hortega Contract (CM18/00198) from the Carlos III Health Institute. J. Cárcel-Márquez is supported by an AGAUR Contract (agència de gestió d'ajuts universitaris i de recerca; FI_DGR 2019, grant number 2019_FI_B 00853) co-financed with Fons Social Europeu (FSE). M. Lledós is supported by a PFIS Contract (Contratos Predoctorales de Formación en Investigación en Salud) from the Carlos III Health Institute
Nuria Sánchez Madrid, Paula Satne (Eds.). (2018). Construyendo la autonomía, la autoridad y la justicia. Leer a Kant con Onora O’Neill. Valencia, VC: Tirant Humanidades. 286 p.
No full textLas editoras Nuria Sánchez Madrid y Paula Satne ofrecen con el presente libro una novedad en la literatura castellana sobre las discusiones de la filosofía kantiana, dado que es la primera vez que se ofrece en este idioma un conjunto de trabajos destinados a discutir las perspectivas de Onora O´Neill.El libro se abre con un prefacio escrito por O´Neill, en el cual ella realiza un recorrido por su trayectoria intelectual, teniendo en cuenta el contexto en el que se ha desarrollado su filosofía práctica y especialmente sus contribuciones a las discusiones éticas y políticas. En lo que sigue nos serviremos de este prefacio para tomar de allí los principales ejes temáticos con los que discuten críticamente los artículos que conforman esta edición.
Brittle Behavior of Corroded Rebars
No full text[ES] La corrosión de las armaduras es una de las principales razones de la reducción de la durabilidad de las estructuras de hormigón armado. Por otra parte, existen diversos mecanismos de corrosión que dan lugar a la generación de diferentes defectos con geometrías diferentes.
El presente estudio se centra en evaluar el comportamiento mecánico de armaduras con diferentes tipos de defectos, desde corrosión generalizada, por picaduras hasta corrosión bajo tensión y fragilización por hidrógeno. Los resultados obtenidos muestran que la resistencia de los aceros no depende únicamente de la pérdida de material, sino que es muy importante evaluar la geometría de los defectos. Estos resultados permiten explicar la variación en el comportamiento mecánico de armaduras corroídas por diferentes métodos.[EN] Corrosion of reinforcement is one of the main reasons for reducing the durability of structures. Corrosion results in the appearance of different defects with different geometries. This study focuses on evaluating
the mechanical behaviour of rebars with different types of defects, from generalised corrosion, pitting to
stress corrosion and hydrogen embrittlement. The results obtained show that the strength of steels does
not depend only on material loss, but that it is very important to evaluate the geometry of the defects.Los autores desean agradecer al Ministerio por la financiación concedida en el Proyecto BIA2013-47892-PPeer reviewe
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
No full textAbstract not availableRaquel Fucho, Laura Martínez, Anna Baulies, Sandra Torres, Nuria Tarrats, Anna Fernandez, Vicente Ribas, Alma M. Astudillo, Jesús Balsinde, Pablo Garcia-Rovés, Montserrat Elena, Ina Bergheim, Sophie Lotersztajn, Christian Trautwein, Hanna Appelqvist, Adrienne W. Paton, James C. Paton, Mark J. Czaja, Neil Kaplowitz, Jose C. Fernandez-Checa, Carmen García-Rui
Actas de las I Jornadas de Bibliotecas y Centros de Documentación sobre mundo árabe e Islam
No full textÍndices: 1. Mª Dolores Oliver Pérez: Ibn 'Arabi y Miguel Asín: comentario a una exposición. P. 11.
2. Francisco Fuster Ruiz: Servicios al investigador de una biblioteca especializada. P. 23.
3. Victoria Aguilar: Bibliotecas en la kora de Tudmir. P. 37.
4. Paz Fernández: Acceso a la documentación sobre mundo árabe e Islam contemporáneo. P. 51.
5. Mª Jesús Viguera Molins: Estructuras del nombre árabe y del título de los libros en lengua árabe. P. 59.
6. Susana Peña Jiménez: Problemas de transliteración de la lengua árabe y automatización. P. 73.
7. Nuria Torres Santo Domingo: Actuación profesional en bibliotecas árabes. P. 85.
8. Francisco J. Navarro Suárez: Gestión e investigación arqueológicas: la Biblioteca del Centro de Estudios Árabes y Arqueológicos "Ibn Arabí". P. 99.
9. Miriam Font Ugalde y Concepción de la Torre de Benito: La Biblioteca de la Escuela de Estudios Árabes de Granada (CSIC). P. 111.
10. Nuria Torres Santo Domingo. La Biblioteca Islámica "Félix María Pareja". P. 129.
11. Mercedes del Amo: Bibliotecarios y arabistas: una colaboración necesaria. P. 13
Long-read sequencing reveals increased isoform diversity in key transcription factor effectors of intercellular signalling at the invertebrate-vertebrate transition
No full textSeveral intercellular signalling pathways (namely wingless - Wnt, Hedgehog - Hh, and Bone Morphogenetic Protein - BMP) are used repeatedly in animals throughout development and evolution, and are also frequent targets for disease-associated disruptions. We have previously shown that the major transcriptional effectors of βcatenin-dependent Wnt signalling, the TCF/LEF proteins, in contrast to other pathway components, have a higher gene number and isoform diversity in vertebrates versus invertebrates, but this increased diversity has only been poorly quantified. Considering that isoform diversity correlates with organism complexity, any increase in major signalling effectors is likely to have made a significant contribution to vertebrate evolution. Using de novo long-read transcriptomes, we compared isoform number per gene for the chordates Ciona intestinalis, Lampetra planeri and Xenopus tropicalis, thus encompassing the invertebrate sister group to vertebrates, as well as a cyclostome and a gnathostome vertebrate. Our results implicate an increase in isoform diversity of the transcription factors of major intercellular signalling pathways as having a disproportionate role in the evolutionary origin and diversification of vertebrates
Tenuiphantes canariensis Wunderlich 1987
No full textTenuiphantes canariensis (Wunderlich, 1987) Taxonomy & Ecology, 1: 157–158 Paratypes. Canary Islands. La Palma, without locality: 3♂ 3 ♀ VII J. Wunderlich leg. (DZUL 24643). Current status: valid species, originally described as Lepthyphantes canariensis (see Saaristo & Tanasevitch 1996). Additional notes: these paratypes were collected by J. Wunderlich and originally published as deposited in his collection (SJW), but were subsequently assigned by the author and kept at DZUL.Published as part of Reboleira, Ana Sofia P. S., Pérez, Antonio José, López, Heriberto, Hernández, Nuria Macías -, Cruz, Salvador De La & Oromí, Pedro, 2012, Catalogue of the type material in the entomological collection of the University of La Laguna (Canary Islands, Spain). I. Arachnida, pp. 61-79 in Zootaxa 3556 on page 74, DOI: 10.5281/zenodo.21283
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