206,015 research outputs found

    Toro-Tapia poster BSDB

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    Differentiating neurons delaminate from the neuroepithelium via the process of apical abscission, which involves loss of apical polarity and primary cilium disassembly. This corresponds with cessation of canonical, Gli transcription factor-dependent Shh signalling and leads to cell cycle exit. Newborn neurons undergo a switch to non-canonical, transcription factor-independent Shh signalling, which mediates axon navigation. As cilia play important roles transducing extracellular signals, it is conceivable that the switch from canonical to non-canonical Shh signalling is mediated by remodelling the cilium during early stages of neuronal differentiation. Live tissue imaging reveals that differentiating neurons retain an Arl13b+ particle which elongates and progressively initiates intraflagellar trafficking as it transits towards the cell body, indicating cilium remodelling. Strikingly, disruption of cilia during and after remodelling inhibits axon extension and leads to dramatic axon collapse respectively. Remarkably, ciliary accumulation of the Shh transducer Smoothened is progressively restored during cilium remodelling in the absence of Gli transcriptional activity. Furthermore, the remodelled cilium also accumulates GPR161, a negative regulator of Gli dependent Shh signalling. These results indicate that newborn neurons are responding to Shh via a non-canonical pathway through the remodelled cilium, providing differentiating neurons the opportunity to configure a new signalling centre. </p

    Choice Experiments in Enviromental Impact Assessment: The Toro 3 Hydroelectric Project and the Recreo Verde Tourist Center in Costa Rica

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    Choice experiments, a stated preference valuation method, are proposed as a tool to assign monetary values to environmental externalities during the ex-ante stages of environmental impact assessment. This case study looks at the impacts of the Costa Rican Institute of Electricity’s Toro 3 hydroelectric project and its affects on the Recreo Verde tourism center in San Carlos, Costa Rica. Compared to other valuation methods (e.g., travel cost and contingent valuation), choice experiments can create hypothetical but realistic scenarios for consumers and generate restoration alternatives for the affected good. Although they have limitations that must be taken into account in environmental impact assessments, incorporating economic parameters—especially resource constraints and tradeoffs—can substantially enrich the assessment process.stated-preference, economic valuation, choice experiments, hydropower, tourism, Costa Rica

    Prefazione

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    Le politiche sull’ambiente assumono un ruolo fondamentale e sempre più importante, perché possono riuscire a modificare quei comportamenti che, se accompagnati a politiche economiche di sostenibilità, possono permetterci di raggiungere un equilibrio tra la salvaguardia delle risorse naturali esistenti, e un loro corretto utilizzo, in modo da proteggerne l’integrità. Il volume contiene i contributi presentati in occasione del convegno organizzato dall’AIL e dall’Università degli studi di Palermo su “Cancerogenesi Ambientale” (Palermo 2013)

    Optimización de parámetros para la extracción de elementos desde minerales en medios ácido

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    [SPA] Esta tesis doctoral se presenta bajo la modalidad de compendio de publicaciones. Actualmente, la gran minería del cobre chilena se encuentra frente a nuevos problemas y desafíos a superar. El principal problema, es de carácter medio ambiental, debido a que la mayor parte de la producción es por procesos de flotación, lo que implica aumentar la generación de relaves, ocasionando drenajes ácidos que generan la movilidad de elementos pesados al medio ambiente. Otro desafío importante, es diversificar las extracciones de otros elementos (como ocurre actualmente con el molibdeno) para impulsar la exportación de productos básicos y aumentar el empleo. Además, se deben tratar recursos que hoy en día no se están aprovechando a escala industrial, un ejemplo son los minerales de cobre negro, estos recursos generalmente no se incorporan en las pilas de lixiviación. Estos minerales exóticos tienen cantidades considerables de Mn (aproximadamente 29%), lo que representa un atractivo comercial. Para abordar este desafío, se realizaron investigaciones a nivel laboratorio, de extracción de cobre y manganeso desde cobres negros mediante procesos de lixiviación. Se evaluaron diferentes aditivos y concentraciones de estos mediante la aplicación de modelos estadísticos de regresión cuadrática, evaluando efectos lineales, interacciones y curvaturas. Además, se diseñaron y probaron con éxito nuevos procesos de extracción. Finalmente, se pudo demostrar que para la disolución de Mn ya sea desde nódulos marinos o cobres negros, se obtienen resultados positivos al adicionar Fe en el sistema, siendo un parámetro óptimo de trabajo una razón de MnO2/Fe de 1/2, logrando extracciones sobre el 70% en tiempos de 20 min. Para la disolución de Cu desde sulfuros secundarios, se puede concluir que los mejores resultados se obtienen al trabajar a elevadas concentraciones de cloruro, siendo poco relevante la concentración de H2SO4. Por otra parte, para la disolución de calcopirita, trabajar en un medio clorurado incorporando altas concentraciones de MnO2 (razones de MnO2/CuFeS2 de 5/1) favorece el mantener un alto valor de potencial en el sistema, superando la pasivación de este mineral.[ENG] This doctoral dissertation has been presented in the form of thesis by publication. Currently, the great copper mining is facing new problems and challenges to overcome. The main problem is environmental, because most of the production is due to flotation processes, which implies increasing the generation of tailings, causing acid drains that generate the mobility of heavy elements to the environment. Another important challenge is to diversify the extractions of other elements (as is currently the case with molybdenum) to boost the export of basic products and increase employment. In addition, resources that are not currently being used on an industrial scale should be treated, an example is black copper ores, these resources are generally not incorporated into the extraction circuits or are not treated, whether in stocks, platforms leaching or waste. These exotic minerals have considerable amounts of Mn (approximately 29%), which represents a commercial appeal. To address this challenge, research was carried out at the laboratory level, for the extraction of copper and manganese from minerals through leaching processes. Evaluating different additives and concentrations thereof, applying the use of statistical models of quadratic regression, evaluating linear effects, interactions and curvatures. And in other cases, creating new extraction processes. Finally, it was discovered that for the dissolution of Mn either from marine nodules or black copper, very positive results are obtained by adding Fe in the system, an optimal working parameter being a ratio of MnO2/Fe of 1/2, achieving extractions above 70% in times of 20 min. For the dissolution of Cu from secondary sulphides, it was found that the best results are obtained when working at high concentrations of chloride, the concentration of H2SO4 being insignificant. On the other hand, for the dissolution of chalcopyrite, working in a chlorinated medium incorporating high concentrations of MnO2 (ratios of MnO2 / CuFeS2 of 5/1) favors maintaining a high potential value in the system, overcoming the passivation of this mineral.Escuela Internacional de Doctorado de la Universidad Politécnica de CartagenaPrograma de Doctorado en Tecnología y Modelización en Ingeniería Civil, Minera y AmbientalScientific Equipment Unit- MAINI of the Universidad Católica del Norte (Chile)Los artículos que componen la tesis son los siguientes: Publicación 1: N. Toro*, M. Saldaña, E. Gálvez, M. Cánovas, E. Trigueros, J. Castillo and P. Hernández. “Optimization of Parameters for the Dissolution of Mn from Manganese Nodules with the Use of Tailings in an Acid Medium” Q2 ISI WoS. Minerals, 2019; https://doi.org/10.3390/min9070387. Publicación 2: N. Toro*, W. Briceño, K. Pérez, M. Cánovas, E. Trigueros, R. Sepúlveda and P. Hernández. “Leaching of Pure Chalcocite in a Chloride Media Using Sea Water and Waste Water” Q1 ISI WoS. Metals, 2019; https://doi.org/10.3390/met9070780. - Publicación 3: M. Saldaña, N. Toro*, J. Castillo, P. Hernández, E. Trigueros, and A. Navarra. “Development of an Analytical Model for the Extraction of Manganese from Marine Nodules” Q1 ISI WoS. Metals, 2019 https://doi.org/10.3390/met9080903. - Publicación 4: N. Toro*, K. Pérez, M. Saldaña, R. I. Jeldres, M. Jeldres and M. Cánovas. “Dissolution of pure chalcopyrite with manganese nodules and waste water” Q1 ISI WoS. Journal of Materials Research and Technology, 2019 https://doi.org/10.1016/j.jmrt.2019.11.020. - Publicación 5 (En Revisión): N. Toro*, W. Briceño, A. Navarra, K. Pérez, M. Cánovas and E. Trigueros. “Statistical and kinetic study for leaching of covellite in a chloride media” Q1 ISI WoS. Journal of Materials Research and Technology.Universidad Politécnica de Cartagen

    Defying the law, negotiating change The Futanke’s opposition to the national ban on FGM in Senegal

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    This thesis is concerned with the politics of the preservation and ‘abandonment’ of female circumcision in Fouta Toro, Senegal. The focal point of analysis is the overt opposition to the law criminalising female genital cutting in 1999, and development projects raising awareness about excision in human rights and reproductive health education programmes. As an ethnography of the politics around bodily practices in the light of governmental and non-governmental intervention, the thesis looks at how different interest groups justify their position towards excision. This is a timely enquiry, given the Senegalese government’s ‘acceleration programme of the complete abandonment of excision by 2015’ and some Futanke leaders’ non-compliance with, and opposition to this intervention. After providing details about ‘the ban’ on ‘female genital mutilation’ in Senegal and a critical reflection on the events that are seen to have led to the call for this ban, I carefully disentangle what ‘the opposition to the law’ is and who disagrees with ‘the abandonment’ of the practice in Fouta Toro. The central part of the thesis is guided by an analysis of how excision is embedded in constructions of personhood, sociality and ethnic identity, and how the body is imagined and located in this process. I show how conceptions of ethnic purity and pride are formulated in terms of fear about a ‘loss of culture’ and ‘foreign invasion’ which nourishes discourses of opposition to the law and non-governmental intervention. Others use ‘human rights’ associated with non-governmental organisations and the state as a vehicle to express their views against excision and those who oppose its criminalisation. I examine how idioms like ‘the state’, ‘human rights’ and ‘Futanke way of life’ feature in discourses around the ban of excision in Fouta Toro, and how respectability and honour are maintained through competing representations of the female body as a site of morality. Some claim the female body – a reproducer of cultural identities – with reference to duties through kin obligations, others with reference to ‘human rights’ and ‘the state’. Based on 15 months’ ethnographic fieldwork in Fouta Toro and nine years working in and researching the impact of development in Senegal, this dissertation contributes to scholarship on Fouta Toro and indicates how governmental and non-governmental intervention stirs up the caste-related power structures of a society led by the Tooroɓɓe since the Islamic revolution in the 18th century. It shows how the female body is located as a site of morality, key to the reproduction of cultural identities
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