1,721,071 research outputs found
High vs. low doses of low-molecular-weight heparin for the treatment of superficial vein thrombosis of the legs: a double-blind, randomized trial
No full textI.F.=5.13
Prothrombotic activity of oral contraceptives in patients with congenital thrombophilia varies with the defect. .
No full textAPC resistance, oral contraceptive therapy and deep vein thrombosis: settled and unsettled problems
Full text link
Immobilization resulting from chronic medical diseases: a new risk factor for recurrent venous thromboembolism in anticoagulated patients
No full textClinical and laboratory expression of associated thrombophilic conditions (homozygous/heterozygous factor V Leiden mutation and heterozygous prothrombin variant 20210A) in an Italian family
No full textProthrombin variant 20210A is maintained to be a mild risk factor for venous thromboembolism (VTE). The association of this defect with other inherited thrombophilic conditions may result in an increased risk of developing VTE. In this article, a family is described in which prothrombin variant was associated with either homozygous or heterozygous factor V Leiden (FV Leiden) mutation. All family members except the proband were asymptomatic despite the presence and the severity of the underlying genetic defect(s). The proband, who carried homozygous FV Leiden mutation and heterozygous prothrombin variant, experienced recurrent VTE during pregnancies, whereas one brother, with the same defect, was asymptomatic. Mean prothrombin antigen and activity levels were higher in carriers of the prothrombin variant as compared with noncarriers. Thrombin generation was assessed in family members, in carriers of prothrombin variant or homozygous FV Leiden mutation and in a control group. Most of the family members presented with increased prothrombin fragment 1+2 levels possibly because of the presence of the FV Leiden mutation. Although it is conceivable that the co-inheritance of prothrombin variant and FV Leiden mutation may increase the risk of VTE, patients with these combined defects may remain asymptomatic. It is likely that acquired triggering conditions play a major role in determining VTE in carriers of a mild genetic predisposition. This has to be taken into account when recommendation for thromboprophylaxis is given
Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes.
No full textAsymptomatic homozygous nt 20210 G to A prothrombin polymorphism in two blood donors belonging to two different kindreds
No full textGender and the risk of venous thromboembolism.
No full textThe role of gender in the causation of first and recurrent venous thromboembolism
(VTE) is uncertain. The use of hormonal therapy and pregnancy has been associated
with VTE in women. Epidemiological studies have described a higher incidence of
first VTE in women of childbearing age. Nevertheless, no consistent differences
in the overall incidence of VTE between males and females have been found. Recent
studies have shown that women exhibit a lower risk of recurrent VTE than men,
although these data were not confirmed in other studies that evaluated only women
with idiopathic VTE. This article reviews the role of gender as a risk factor for
first and recurrent VTE
- …
