119 research outputs found
Investigation of bla(OXA-48)-Like Genes in Carbapenemase Producing Klebsiella spp. Isolates
No full textThe emergence and spread of multi-drug-resistant (MDR), extended-spectrum beta-lactamase (ESBL) producing carbapenem-resistant members of Enterobacteriaceae family has become a worldwide health problem. Carbapenem resistance caused by bla(KPC), bla(NDM) gene regions are sporadic and bla(OXA-48) gene region is endemic in our country. The aim of this study was to determine the presence of bla(OXA-232), bla(OXA-181), bla(OXA-162), bla(OXA-204), bla(OXA-244), bla(OXA-163), bla(OXA-245) genes in OXA-48 like carbapenemase producing Klebsiella pneumoniae isolates. The isolates used in this study were provided from the Medical Microbiology Laboratory collection of Sakarya University Sakarya Training and Research Hospital. Identification and antibiotic susceptibility tests were determined by the VITEK 2 (R) automated system (biomerieux, France) and the carbapenemase production of isolates was determined by the modified Hodge test. Minimal inhibitor concentration (MIC) values were determined with broth microdilution method. The isolates containing the bla(OXA-48)-like gene region were identified by real-time polymerase chain reaction (Rt-PCR) method using consensus primers. In "High Resolution Melting Analysis (HRMA)" method carried out by using "Type-it HRM PCR" (Qiagen, Hilden, Germany) kit, isolates which showed a deviation in melting temperatures (Tm) were selected with the suspicion of OXA-48 variant. The sequence analysis (ABI 3500, Applied Biosystems, USA) was carried out to determine which variants were present in these isolates. Compatibility of MIC values was determined between VITEK 2 (R) and the microdilution method with the rate of 82% for imipenem, 77% for meropenem and 90% for ertapenem in carbapenemase-producing K. pneumoniae isolates. In 45 of 100 K. pneumoniae isolates, the bla(OXA-48)-like gene region was found to be positive by the Rt-PCR method. For the determination of OXA-48 variants, these 45 isolates were evaluated by HRMA method. The sequence analysis revealed that 41 (91.2%) isolates contained bla(OXA-48)/bla(OXA-245) gene regions, while 2 (4.4%) isolates were found to contain bla(OXA-181) gene regions and 2 (4.4%) isolates were found to contain bla(OXA-244) gene regions. This is the first study to determine OXA-48 and OXA-244 positivity in bla(OXA-48)-like gene regions in Turkey. As a result of this study, the OXA-48-like gene region was found to be 45%, of which 4.4% had bla(OXA-181) and 4.4% had bla(OXA-244) gene regions. The detection of bla(OXA-48)-like gene regions will guide for the selection of antibiotics in critical patient groups
Combining Acceleration Techniques for Pricing in a Vrp With Time Windows
No full textHande Küçükaydın (MEF Author)##nofulltext##..
Column Generation Based Algorithms for a Vrp With Time Windows & Variable Departure Times
No full textHande Küçükaydın (MEF Author)##nofulltext##..
From Thread to Fabric: Anthropology and Its Interpreters
No full textIn the Conclusion of the book edited by Hande Birkalan Gedik and Fabiana Dimpfelmeier, the author traces the dynamics between the thread and the fabric, going back to Fredric Barth's seminal 2000 Sydney Mintz lecture, published in 2002. Using different examples, from ideas that speak of global anthropological concerns, to the more particular issues of what it means to produce (and use) the anthropological knowledge, the chapter emphasizes the need to understand different regional traditions.This open access edition of ‘Fabrics of Anthropological Knowledge: Changing Perspectives in Europe and Beyond’,
edited by Hande Birkalan-Gedik and Fabiana Dimpflmeier has been funded by Georg und Franziska Speyer’sche
Hochschulstiftung and the Open Access Publication Fund of Goethe University Frankfurt am Main
Correction to: Digitalization of Business Logistics Activities and Future Directions
No full textThe original version of Chapter 10 was inadvertently published with the incorrect authors affiliation. For authors Ebru Beyza Bayarçelik and Hande Begüm Bumin Doyduk the corrected affiliation is provided below: Ebru Beyza Bayarçelik Department of International Trade and Logistics Management, Faculty of Business and Management Science, Maltepe University, Maltepe, Istanbul, Turkey e-mail: [email protected] Hande Begüm Bumin Doyduk Hande Begüm Bumin Doyduk (Corresponding author), Department of International Trade, School of Business, Altınbaş University, Esentepe, Istanbul, Turkey e-mail: [email protected] Corrections have been updated in the book. © Springer Nature Switzerland AG 2020
Detection of the Presence of Extended-Spectrum Beta-Lactamase Enzyme in Gram-negative Bacteria According to CLSI and EUCAST Criteria
No full text
Seller's liability for defected goods under the Turkish Code of Obligations and the Vienne Sales Convention and particularly buyer's right to claim damages under the Vienne Sales Convention
No full textBu çalışma, Özyeğin Üniversitesi Sosyal Bilimler Enstitüsü'nde yüksek lisans tezi olarak hazırlanmıştır. Tezde araştırılan konu, Viyana Satım Sözleşmesi ve Türk Borçlar hukuku açısından ayıplı ifadan dolayı alıcının sahip olduğu seçimlik haklar ve özellikle Viyana Satım Sözleşmesi'ne göre önemli bir hak olan tazminat hakkıdır. Giriş bölümünde konunun seçimindeki etkenler ve inceleme tarzı, terminoloji tercihi ele alınmıştır. Birinci bölümde Viyana Satım Sözleşmesi'nin uygulama alanı, yer bakımından, maddi bakımdan ve zaman bakımından ele alınmış ve sonrasında Türk Borçlar Kanunu ile Viyana Satım Sözleşmesi uyarınca ayıptan doğan sorumluluk karşılaştırmalı olarak incelenmiştir. İkinci bölümde, alıcının Viyana Satım Sözleşmesi uyarınca ayıplı ifa sonucu tazminat talep etme hakkı ayrıntılı olarak incelenmiştir. Sonuç bölümündeyse, tezde araştırılan konular ve yapılan çıkarımlar bir arada sunulmuştur. Anahtar Kelimler: Viyana Satım Sözleşmesi, VSS, Ayıptan Doğan Sorumluluk, Tazminat.This study is prepared as a Master of Laws thesis for the Institute of Social Sciences at Ozyegin University. This thesis focuses on the buyer's remedies against seller for product liability, particularly the right to compensation according to the United Nations Convention on Contract for the International Sale of Goods as well as the Turkish Code of Obligations. The introduction focuses on the main reasons and influences that led to the selection of this research subject as well as the research methods that were used within this study and explains the preference of terminology. The first chapter consists of the analysis of the ratione materiae and ratione temporis scopes of the UN Convention on Contract for the International Sale of Goods as well as a comparative analysis as regards to the liability for defective products according to the Turkish Code of Obligations and the UN Convention on Contract for the International Sale of Goods. The second chapter assesses in great detail the buyer's claim for compensation in cases of product liability according to the UN Convention. Lastly, the conclusion provides a holistic evaluation consisting of the research subjects within this study as well as the final deductions and notes of the author of this thesis. Keywords: The United Nations Convention on Contracts for the International Sale of Goods, CISG, Product Liability, Buyer's Remedies, Claim for Compensation
Hope Speech detection in under-resourced Kannada language
No full text@article{hande-etal-kanhope,
title = "Hope Speech detection in under-resourced Kannada language",
author = "Hande, Adeep and
Priyadharshini, Ruba and
Sampath, Anbukkarasi and
Thamburaj, Kingston Pal and
Chandran, Prabakaran and
Chakravarthi, Bharathi Raja ",
journal={SN Computer Science},
publisher={Springer}
}Numerous methods have been developed to monitor the spread of negativity in modern years by eliminating vulgar, offensive, and fierce comments from social media platforms. However, there are relatively lesser amounts of study that converges on embracing positivity, reinforcing supportive and reassuring content in online forums. Consequently, we propose creating an English-Kannda Hope speech dataset, KanHope and comparing several experiments to provide benchmarking for the dataset. The dataset consists of 6,176 user-generated comments in code mixed Kannada crawled from YouTube and manually labelled as bearing hope speech or not-hope speech. In addition, we introduce DC-BERT4HOPE, a dual-channel model that uses the English translation of KanHopeEDI for additional training to promote hope speech detection. The approach achieves a weighted F1-score of 0.756, bettering other models. Henceforth, KanHope aims to instigate research in Kannada while broadly promoting researchers to take a pragmatic approach towards online content that encourages, positive, and supportive
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