1,721,011 research outputs found
Alternanza di Governo nell’Unione Europea 2008-2015
No full textLo studio del populismo sta vivendo un periodo di grande fulgore, testimoniato da una copiosa produzione scientifica e da una costante attenzione mediatica. Partiti e movimenti populisti hanno ottenuto significativi successi elettorali in diversi paesi europei e, sebbene in appena tre casi una forza politica di questo tipo si trovi al governo (Ano 2011 in Repubblica Ceca, Syriza in Grecia e Law and Justice in Polonia), la loro affermazione elettorale ha tolto voti sia ai partiti di governo che alle opposizioni.European politics seems to be in a period of dramatic change. Exasperated by the Great Recession, voters are disillusioned and the political class suffers from a loss of trust, with mainstream political parties losing popularity and party membership. Europe's political crisis of representation also shows itself in the rise of new forms of ‘anti-system politics’, notably the insurgency of new forms of populism and anti-establishment politics. Mainstream political parties are losing votes and the voter turnout is decreasing in several countries.
Whilst covering the characteristics of ‘new parties’ and populist parties in Europe, this research investigates the government turnovers in the 28 EU countries, showing that mainstream political parties have been able to resist in power in several cases, through the help of the voting systems’ features and the establishment of grand coalitions
The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity
No full textThe anthrax lethal factor is a multi-domain protein toxin released by Bacillus
anthracis which enters cells in a process mediated by the protective antigen and
specific cell receptors. In the cytosol, the lethal factor cleaves the N-terminal
tail of many MAPK kinases, thus deranging a major cell signaling pathway. The
structural features at the basis of these activities of LF are reviewed here with
particular attention to the proteolytic activity and to the identification of
specific inhibitors. A significant similarity between the metalloprotease domain
of the lethal factor and of that of the clostridial neurotoxins has been noted
and is discussed
Mass Media and Moral Panics: How to Cover Violence against Women (and Win Elections) in 365 Days of Italian TV Evening News
No full text
I democratici americani a metà del guado
No full textQuesto articolo analizza la situazione attuale del Partito Democratico americano, le sue caratteristiche, le correnti interne, le chances elettorali, il personale politico
Short linear motifs characterizing snake venom and mammalian phospholipases a2
Full text linkSnake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve transmission, and the induction of muscle necrosis. The biological properties of these proteins are not only due to their enzymatic activity, but also to protein–protein interactions which are still unidentified. Here, we compare sequence alignments of snake venom and mammalian PLA2s, grouped according to their structure and biological activity, looking for differences that can justify their different behavior. This bioinformatics analysis has evidenced three distinct regions, two central and one C-terminal, having amino acid compositions that distinguish the different categories of PLA2s. In these regions, we identified short linear motifs (SLiMs), peptide modules involved in protein–protein interactions, conserved in mammalian and not in snake venom PLA2s, or vice versa. The different content in the SLiMs of snake venom with respect to mammalian PLA2s may result in the formation of protein membrane complexes having a toxic activity, or in the formation of complexes whose activity cannot be blocked due to the lack of switches in the toxic PLA2s, as the motif recognized by the prolyl isomerase Pin1
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