229 research outputs found
Abstract 3818: Identification of a <i>FGFR3-TACC3</i> fusion in esophageal cancer
No full textAbstract
Aberrant activation of fibroblast growth factor (FGF) signaling has been found to contribute to carcinogenesis. Recently, activating FGFR fusions are detected in several malignancy. However, limited information is available regarding the existence of FGFR fusions in esophageal squamous cell cancer (ESCC) and gastric cancer (GC). In this report, we explored major FGFR1, FGFR2, and FGFR3 fusion transcripts in ESCC and GC specimens (n = 74 and 114, respectively) using a most comprehensive next-generation sequencing panel. We detected a targetable fusion between exon 18 of FGFR3 and exon 11 of TACC3 at a frequency of 1.4% (1/74) in ESCC, whereas other FGFR fusions were not detected in the ESCC or GC specimens analyzed. Furthermore, split FGFR3 signals were apparent in this specimen by fluorescence in situ hybridization (FISH) with break-apart probes. The patient, a 64-year-old man with unresectable T4bN3M1 poorly differentiated ESCC of stage IV, was treated with palliative chemoradiotherapy followed by taxane chemotherapy. The patient died of cancer progression, with his overall survival time having been 9.5 months.
Our results provide sequence information that should prove useful for development of simple and cost-effective diagnostic assays as an alternative to FISH for patients with ESCC harboring the FGFR3-TACC3 fusion.
Citation Format: Takuro Mizukami, Kazuko Sakai, Saeko Naruki, Tomoko Taniyama, Yoshiki Horie, Naoki Izawa, Takashi Tsuda, Takashi Fujino, Narikazu Boku, Hiroshi Yasuda, Tetsu Fukunaga, Takako Eguchi Nakajima, Kazuto Nishio. Identification of a FGFR3-TACC3 fusion in esophageal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3818. doi:10.1158/1538-7445.AM2017-3818</jats:p
Letter from Alan Nishio, Los Angeles Community Coalition on Redress/Reparations, William E. White, Senior Inspector I, Street Use Inspection Division, Bureau of Street Maintenance, City of Los Angeles, January 29, 1981
No full textLetter from Alan Nishio, Los Angeles Community Coalition for Redress/Reparation (LACCRR), to William E. White, Senior Inspector I, regarding the Hold Harmless Agreement. A business card with handwritten notes is also included.The Jim Matsuoka Nikkei for Civil Rights and Redress Collection includes brochures, meeting notes and agendas, publications, booklets, and other material related to the Nikkei for Civil Rights and Redress (NCRR), formally known as the National Coalition for Redress/Reparations. The National Coalition for Redress/Reparations was officially formed on July 12, 1980, and included members of the Los Angeles Community Coalition for Redress/Reparations (LACCRR), Japanese Community Progressive Alliance (JCPA), Tule Lake Committee, Nihonmachi Outreach Committee, the Asian/Pacific Student Union, and other members of the community. The material was collected by Jim Matsuoka, a founding member of the organization. Matsuoka also served on the board and was the treasurer. In addition to the NCRR material, the collection also contains event flyers and Day of Remembrance material. For issues of the Nikkei for Civil Rights and Redress newsletter "Banner" published after 2007, visit the NCRR website at https://ncrr-la.org/
Racemization of chiral sulfoxide using an immobilized oxovanadium catalyst
No full textThis is a pre-copyedited, author-produced version of an article accepted for publication in Bulletin of the Chemical Society of Japan following peer review. The version of record Nishio Tomoya, Shigemitsu Hajime, Kida Toshiyuki, et al. Racemization of chiral sulfoxide using an immobilized oxovanadium catalyst. Bulletin of the Chemical Society of Japan 98, 3651 (2024) is available online at: https://doi.org/10.1093/bulcsj/uoae144.Racemization of optically active compounds is an essential process in asymmetric transformations such as dynamic kinetic resolution and deracemization. In this study, the racemization of chiral sulfoxides under mild thermal conditions was realized using a novel silica-gel-supported oxovanadium catalyst. Specifically, we screened reaction conditions, analyzed the substrate scope, and conducted mechanistic studies of the silica-gel-supported oxovanadium-catalyzed racemization of sulfoxides. The racemization reaction has a wide substrate scope, including alkyl aryl sulfoxides and diaryl sulfoxides. The catalyst could be reused by exploiting its heterogeneous nature. Mechanistic studies suggested that racemization proceeds via the formation of a radical cation intermediate mediated by the oxovanadium(V)/(IV) redox cycle
Quantum Mechanical Calculation of the Bond Moments : The Effects of the Polar Substituents on the Intensity of the Absorbed Spectrums
No full textThe author calculated the exchange electric moments of keton and benzen derivatives by the Linear Combination of Atomic Orbital Method. In the case of keton derivatives, the frequencies increase in proportion to the electronegativities of substituents, but the intensities are independent. In the case of benzen derivatives, the frequencies ν decrease in proportion to the electronegativities ⊿ε as follows, ν (1013sec-1)=120-55.⊿ε(e.u.) And the intensities decrease in proportion to the frequencies as follows, log εmax=14.0-0.1ν These results are compared with the observed values
Relation between Chemical Structure and Pharmaceutical Reacitn
No full textThe author discuss the primitive pharmaceutical actions where their fundamental processes are of physico-chemical mechanisms, and arrive at the following conclusions. (1) The logarithm of the lowest effective-concentration M can be represented by the addition of a constant Un particular to each group in the molecule. (2) The fundamental characteristic of pharmaceutical mechanism will be reasoned from the value of the additive constant and the equation. (3) There are two types of addition. One type has a center of action where the amount of the additive constant Un is large and based on pure chemical reactions and is represented by log M=U0+∑τnUn where τn is a steric constant. (4) The other type has no center and all groups contribute equally to the action where Un is comparably small and based on physico-chemical reactions, such as vaporization, dissolution and diffusion, and is represented by log M=∑σnUn where σn is a steric constant. We have confirmed these equations in many examples
Mixed cell type in airway inflammation is the dominant phenotype in asthma patients with severe chronic rhinosinusitis
No full textMixed cell type in airway inflammation is the dominant phenotype in asthma patients with severe chronic rhinosinusitis
No full text名古屋大学Nagoya University博士(医学)doctoral thesi
Competition in network industries
No full textA wave of privatization is sweeping the globe, affecting about 100 countries and adding up to an average of more than $60 billion a year in business in the past decade. The challenge is to ensure that privatization yields clear benefits. Empirical studies suggest that ownership change by itself will often yield results, especially when it reduces government interference. But the regulation required in areas of natural monopoly can become overly intrusive and undermine progress. Real competition is required to generate sizable and lasting welfare improvements. But in infrastructure sectors, the introduction of competition is complicated by the existence of complex transport and communications networks. Debate about whether and how to introduce competition in network industries is sometimes heated. Certain questions recur: Will continuing regulation be needed? Whether and at what terms will private finance be forthcoming? The author argues that policymakers need to understand how competitive forces can be brought to bear in network industries. He explains the following: 1) common principles that are often lost in"technical"debates about specific sectors; 2) various methods for introducing competition in network industries; 3) competition for the market, and bidding for franchises; 4) options for competition for existing networks; 5) options for expanding competitive systems by decentralizing investment in new network capacity; 6) the option of allowing competition among multiple networks; and 7) the implications of these options for the sectors and for financing industry expansion. In case of doubt, he contends, policymakers should not restrict the entry of competitive firms in such networks. If they do, entry restrictions should be subject to an automatic test after a set period, and reviewed for costs and benefits.Economic Theory&Research,Decentralization,Markets and Market Access,Environmental Economics&Policies,Labor Policies,Education for the Knowledge Economy,Economic Theory&Research,Access to Markets,Markets and Market Access,Environmental Economics&Policies
Retrip: A Learning Environment for Augmenting and Presenting Knowledge from Field Trip
No full textAbstractIn this work, we have focused on experiential learning in field trip. In the field trip, we think experiential knowledge from field trip could be obtained, augmented, and strengthened via the following three phases: pre-trip (planning), trip (investigation), and post-trip (augmentation and presentation). However, learners often fail to investigate historical and cultural spots as planned due to some accidents. In addition, their interests in the spots could change during the trip, and then the new goals may arise. So, it is not easy for the learners to obtain their experiential knowledge as expected. In this paper, we demonstrate an experiential learning environment on iPad called Retrip. Retrip provides the learners with several scaffolds for seamlessly obtaining, augmenting, and presenting their experiential knowledge from trip planning to presentation
The Reprinting and Explanation of Meisho-waka-shōshutsu in the possession of Iwase Library in Nishio City (2)
No full textdepartmental bulletin pape
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