39 research outputs found
Investigation of Wound Healing and Anti-Inflammatory Activities of Solvent Fractions of 80% Methanol Leaf Extract of Achyranthes Aspera L. (Amaranthaceae) in Rats [Retraction]
No full textMengie T, Mequanente S, Nigussie D, Legesse B, Makonnen E. J Inflamm Res. 2021;14:1775—1787.
We, the Editors and Publisher of the Journal of Inflammation Research, have retracted the following article.
Since publication, concerns have been raised about the integrity of the data in the article, specifically image duplication in Figure 2. When approached for an explanation, the authors have been unable to provide their original data or the relevant supporting documentation. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The corresponding author listed in this publication has been informed. The authors do not agree with the retraction.
We have been informed in our decision-making by our editorial policies and the COPE guidelines.
The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’
What Should Be Done: Dealing with Dacca's Urban Poor
No full textThis thesis is about the squatter phenomena in Dacca, Bangladesh. The author reviews and synthesizes existing programs and policies that have been developed to deal with the squatter phenomenon around the Third World and subsequently the development of a program for applying these to Dacca in a realistic and effective manner. The author provides an understanding of, and solutions for, the existing problem with provisions for the expected growth of the influx of rural populations. The troubled economy, low per capita income, etc., are problems that directly face the urban poor, and their improvement would undoubtedly greatly improve the conditions of this sector of society. The author focuses on how to provide the people without legal title to a place to live, improving the resulting sub-human living conditions they endure, and making available some of the basic needs of human life; i.e., access to shelter, clean water, food, and employment. Methodology includes participant observation, formal and informal interviews, and surveys
Tourism as a Strategy for Development in Jamaica
No full textThe image of tourism is one of the main obstacles facing the industry. The image has come to override the truth, and the industry is experiencing difficulties with coming to terms with the reality, and treating tourism as it should be, as a multidimensional and worthy strategy for development. The author argues that if tourism in Jamaica is to succeed as a sustainable strategy for development, officials must go beyond the image of tourism, understand the various areas that affect and are affected by the industry, and plan wisely and in collaboration with one another to produce a first class product appropriate for Jamaica. Methodology focuses on tourists and their hosts, tourism and the economy, society, and the environment, as well as dependency, imperialism, image, and planning
A bibliometric analysis of the factors influencing global research conditions of teacher education
No full textThis bibliometric analysis explores global research trends in teacher education, examining 1,757 publications from the Lens.org database (1878-2023). The study reveals a significant upwelling in teacher education program research, particularly since 2015, with journal articles dominating the publication landscape. Arthur Tatnall emerged as the most prolific author, while psychology, medicine, and medical education were identified as the top contributing fields. The analysis highlights the United States, United Kingdom, Australia, China, and Canada as leading research nations, underscoring a concentration of output in developed countries. Key influencing factors identified include the impact of the COVID-19 pandemic, technological integration, and the need for adaptive and equitable strategies. The findings emphasize the interdisciplinary nature of teacher education program research and the critical need for increased capacity building and international collaboration, especially in underrepresented regions
Retrospective Study of Recurrence and Associated Factors of Type 2 Diabetes Treated at Adama General Hospital, Oromia, Ethiopia: A Comparison of Cox-PH and Shared Lognormal Frailty Models
No full textBACKGROUND: Recovery from type 2 diabetes is frequently recurrent, as a single patient may recover from more than one over time. The goal of this study was to know the recurrent event (time to recovery) and associated factors of type 2 diabetes in Adama General Hospital, Ethiopia, by comparing shared lognormal frailty and Cox-PH models. METHODS: A retrospective analysis of 302 type 2 diabetic patients (01, 2011–01, and 2016) was considered. Descriptive statistics were used to summarize the study variables. The standard Cox-proportional hazards model and a shared lognormal frailty model have been compared. The latter model with a 95% significance level was fitted, variables with P value < 0.05 were considered significant, and the adjusted hazard ratio has been used to measure the strength of the risk. RESULTS: About 56.6% of the patients recovered. The average recovery time was 33.53 (standard deviation, 20.404 ) weeks. Gender (adjusted HR = 1.168, 95% CI = (0.93, 1.46), P < 0.05), family history (adjusted HR = 0.765, 95% CI = (0.59, 0.99), P < 0.05), cholesterol level (adjusted HR = 0.738, 95% CI = (0.57, 0.96), P < 0.05), alcohol use (adjusted HR = 0.698, 95% CI = (0.53, 0.92), P < 0.05), and smoking cigarette (adjusted HR = 0.674, 95% CI = (0.51, 0.89), P < 0.05) were statistically significant. The estimated frailty term's variance was 0.426 (P value=0.028). Also, the author presents a comparison study for the same data by using a model selection criterion and suggests a better model (shared lognormal frailty model). CONCLUSION: Finally, the median recovery time was 30 weeks. Female patients had a better chance of recovery than male patients. A shared lognormal frailty model outperformed the Cox-PH model in fitting the data and controlling event interdependence. There was risk heterogeneity among patients. Positive family history, high cholesterol level, alcohol use, and smoking have an inverse relationship with the overall likelihood of the patients' recovery time. Therefore, future improvement measures against type 2 DM recovery should take all events (for example, the first, second, and third recovery in this study) and these identified factors into account
Urban land acquisition and social justice in Ethiopia
No full textAs urban land could be used for manifold purposes, urban residents look for such land enthusiastically to serve their enormously diverse interests. Thus, urban land use laws and policies should be flexible, apt and transparent to respond to such various and complex land demands. An inflexible form of land transfer and management system may drive some section of the society out of the land deal and an extremely flexible urban land permission and use system could result in a pervasive corruption and that in turn could lead to bad governance. In this work, the author argues that the existing urban land acquisition system of Ethiopia has resulted in social injustice by denying the poor from access to urban land; and creating discriminatory environment while enforcing the new lease system
Participatory identification of indicators for assessing options for climate compatible development of smallholder farmers in the Central Rift Valley of Ethiopia.
No full textUrban land acquisition and social justice in Ethiopia
No full textAs urban land could be used for manifold purposes, urban residents look for such land enthusiastically to serve their enormously diverse interests. Thus, urban land use laws and policies should be flexible, apt and transparent to respond to such various and complex land demands. An inflexible form of land transfer and management system may drive some section of the society out of the land deal and an extremely flexible urban land permission and use system could result in a pervasive corruption and that in turn could lead to bad governance. In this work, the author argues that the existing urban land acquisition system of Ethiopia has resulted in social injustice by denying the poor from access to urban land; and creating discriminatory environment while enforcing the new lease system.Keywords: access to land, land lease, social justice, tenure security, urban land polic
Understanding the Structure and Function of GABAA Receptors Using Cryo-Electron Microscopy
No full textThe general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.Pages 17-156 are misnumbered as pages 15-154.γ-Aminobutyric acid type A (GABAA) receptors are essential for maintaining the delicate balance of excitatory and inhibitory signaling in the brain, playing a pivotal role in regulating neuronal function and communication. These receptors are targeted by a wide range of therapeutic compounds, including anxiolytics, sedatives, and anticonvulsants, as well as endogenous neurosteroids that modulate their function. Among these neurosteroids, a subset acts as positive allosteric modulators of GABAA receptors, enhancing the inhibitory effects of GABA. Allopregnanolone, a prominent member of this group, is the only drug specifically approved for the treatment of postpartum depression, demonstrating the clinical relevance of these modulators.
While recent advances in structural, physiological, and photolabeling studies have provided a growing consensus on the binding sites of positive modulators, the exact mechanism by which they potentiate GABA activation remains a subject of ongoing investigation. In contrast, the binding sites, and modes of action of negative modulators, which are other neurosteroids that inhibit GABAA receptor function, are still under debate and require further elucidation.
The first part of this thesis describes the work I have done during the last two years, during which I determined structures of a synaptic GABAA receptor bound to allopregnanolone and two inhibitory sulfated neurosteroids, providing new insights into their respective modes of action. Our findings reveal that allopregnanolone binds at the receptor-bilayer interface, occupying a consensus potentiator site, while the inhibitory neurosteroids interact with the receptor at a distinct location within the pore. By employing molecular dynamics (MD) simulations and electrophysiological experiments, we propose a mechanistic model that accounts for the potentiating effects of allopregnanolone on channel activity. Furthermore, our results suggest that the primary mechanism underlying the inhibitory actions of sulfated neurosteroids is the obstruction of the pore, leading to reduced ion flow and channel activity. These findings contribute to our understanding of GABAA receptor modulation and may have implications for the development of novel therapeutic agents targeting these receptors
