37 research outputs found
Data Set of PLOS Computational Paper PCOMPBIOL-D-18-02181R1
No full textFigures Data of PLOS Computational paper:Modeling of the axon plasma membrane structure and its effects on protein diffusionAuthors: Yihao Zhang, Anastasios V. Tzingounis, and George LykotrafitisCorresponding Author: George Lykotrafitis, Ph.D.University of ConnecticutStorss, CT UNITED STATES</div
New historical evidence for Anastasios Emm. Papas
No full textNo AbstractThe author’s attention has been drawn to the existence of this historicalevidence in the National Archives of Vienna, by his friend the writer EteoclesGregoriadis together with the numbers of the relevant files. Most of the documents were written in the old German script. Thus the author asked for the help of his friend and former colleague at the University of Thessaloniki and director of the Goethe Institute, Graf Kurt v. Posadowsky, for reading andstudying those documents. Without his help this study would have been impossible. This new evidence concerns the sojourn of Anastasios Papas·—son of Emmanuel Papas, leading figure of the Greek Revolution—in Austria andGermany between the 3rd January and 11th March 1822. There is informationabout his short imprisonment in Trieste, after his arival from Vienna. He then visits various towns in Germany and after negotiations with the Philhellene professor Fr. Thiersch in Munich, he purchases large quantities of ammunition to be despatched to Greece. He finally arrives in Greece early in 1824, and takes part—together with his three brothers who were already fighting—in the struggle for the liberation of the common great fartheland
Tension band plating of an anterior tibial stress fracture nonunion in an elite athlete, initially treated with intramedullary nailing: a case report
No full textAbstract Background Leg pain in athletes is a common condition and is often related to tibial stress fracture. When non-operative treatment fails, the optimal surgical treatment is controversial. The aim of this study was to report a case of tension band plating of an anterior tibial stress fracture nonunion, treated previously with intramedullary nailing. To the best of our knowledge, this is the first reported case in which tension band plating was placed without removing the preexisting intramedullary nail. Case presentation The tibial shaft is a common location of stress fracture in athletes. Anterior tibial stress fractures are difficult to manage. When conservative treatment fails, intramedullary nailing is the mainstay of treatment. However, nonunion is a serious complication. In our case, a non-united anterior tibial stress fracture, treated with intramedullary nailing, was addressed with the application of a compression prebended plate over the nail in a 23-year-old French man of African origin who is an elite football player. At 3-months postoperatively he was pain free and started light exercises. At 6-months postoperatively, complete radiologic union of the fracture was evident. He was symptom free; he resumed at that time a full training program and he returned to play football at preinjury high competition level. Conclusions Compression plating is a valuable method of treating non-united anterior tibial stress fractures. We believe that anterior tension band plating is superior to intramedullary nailing in managing anterior tibial stress fractures, not only after failure of intramedullary nailing, but also as a first-line surgical treatment. This technique offers advantages, such as no violation of the extensor mechanism and risk of anterior knee pain, and directly addresses the underlying problem of distraction forces acting on the anterior tibial cortex and compromising fracture healing. Especially in high-level athletes, who cannot tolerate prolonged inactivity, early surgical intervention of anterior tibial stress fractures with tension band plating is a reliable option that can accelerate recovery
Distributed IDA-PBC for Nonholonomic Mechanical Systems
No full textNonholonomic mechanical systems encompass a large class of practically interesting robotic structures, such as wheeled mobile robots, space manipulators, and multi-fingered robot hands. However, few results exist on the cooperative control of such systems in a generic, distributed approach. In this work we extend a recently developed distributed \ac{IDA-PBC} method to such systems. More specifically, relying on port-Hamiltonian system modelling for networks of mechanical systems, we propose a full-state stabilization control law for a class of nonholonomic systems within the framework of distributed \ac{IDA-PBC}. This enables the cooperative control of heterogeneous, underactuated and nonholonomic systems with a unified control law. This control law primarily relies on the notion of Passive Configuration Decomposition and a novel, non-smooth control law proposed here. A low-level collision avoidance protocol based on the \ac{APF} method is also implemented in order to achieve dynamic inter-agent collision avoidance, enhancing the practical relevance of this work. Theoretical results are tested in different simulation scenarios in order to highlight the applicability of the derived method.Mechanical Engineering | Systems and Contro
Multiple sets of solutions for harmonic elimination PWM bipolar waveforms: Analysis and experimental verification
Get PDFMultiple sets of solutions for the selective harmonic elimination pulse-width modulation method for inverter control exist. These sets present an independent solution to the same problem but further investigation reveals that certain sets may offer an improved overall harmonic performance. In this paper, a minimization method is discussed as a way to obtain these multiple sets of switching angles. A simple distortion harmonic factor that takes into account the first two most significant harmonics present in the generated waveform is considered in order to evaluate the performance of each set. The bipolar waveform is thoroughly analyzed and two cases are considered; single-phase patterns which eliminate all odd harmonics and three-phase counterparts which eliminate only the nontriplen odd harmonics from the line-to-neutral pattern but such harmonics are naturally eliminated from the line-to-line waveform. Experimental results support the theoretical considerations reported in the paper
Osgood-Schlatter Lesion Removed Arthroscopically in an Adult Patient
No full textOsgood-Schlatter disease is a traction apophysitis of the tibial insertion of the patellar tendon. It consists one of the most common causes of knee pain in adolescents and usually presents in young males and it is considered a self-limiting condition. Although the symptoms disappear after the closure of the growth plate in most cases, in some patients they may persist. A variety of conservative treatments are used in most cases, however surgical intervention can be successful for patients who have intolerable symptoms. Most surgical options of the Osgood-Schlatter disease include open procedures, while arthroscopic or direct bursoscopic excision has been reported. We believe that the arthroscopic removal of an unresolved Osgood-Schlatter might be the most appropriate treatment for this condition, and we present a case of a male patient with an ununited ossicle due to an Osgood-Schlatter lesion, which was removed arthroscopically using a multidirectional arthroscope and a motorized semi-hooded barrel burr
Arthroscopic Anterior Cuciate Ligament Reconstruction Using Neither a Tourniquet nor Drainage: A Perioperative Case Series Report
No full textIntroduction: Many orthopedic surgeons recommend ischemic tourniquets during arthroscopic anterior cruciate ligament (ACL) repair to reduce blood loss and improve visibility. However, their use remains controversial due to potential complications. Similarly, the practice of postoperative drainage is debated. While its proponents argue it reduces limb swelling, DVT, adhesions, and stiffness, others contend that it may increase infection risk or harm the ACL graft and joint surfaces. Materials and Methods: A total of 456 patients underwent anterior cruciate ligament reconstruction between September 2015 and December 2024, without the use of a tourniquet or drainage. The patients were 334 men with a mean age of 34.7 years and 122 women with a mean age of 32.3 years. In 389 cases the graft type was a hamstring autograft, in 55 cases a patellar tendon autograft (BPTB) was used, and in 12 cases a quadriceps tendon autograft was used. Results: The mean operative time was 61 min (range 52–79). No cases experienced visual impairment or required ischemia to enhance visibility. Bleeding sites were successfully cauterized during arthroscopy. Postoperative complications included knee hematoma in three patients (0.7%), resolved after drainage on day one, and two infections (0.4%), treated successfully with arthroscopic drainage and implant removal. No further complications were reported. Conclusion: Although many orthopedic surgeons prefer arthroscopic ACL repair with a tourniquet for better visibility and reduced intraoperative blood loss, this approach carries risks such as nerve palsy, joint swelling, stiffness, muscle weakness, and vascular changes. Not using a tourniquet can help to identify bleeding sites and allows for a more thorough procedure. The literature suggests that avoiding a tourniquet also reduces postoperative pain and accelerates recovery. The mean operative time for ACL reconstruction was consistent with the literature, indicating that avoiding a tourniquet did not cause delays. Additionally, the absence of postoperative drainage did not lead to complications, with most patients showing no issues like bleeding, hematoma, ischemia, or poor wound healing
Development of a cost-effectiveness model for optimisation of the screening interval in diabetic retinopathy screening
Get PDFBACKGROUND:
The English NHS Diabetic Eye Screening Programme was established in 2003. Eligible people are invited annually for digital retinal photography screening. Those found to have potentially sight-threatening diabetic retinopathy (STDR) are referred to surveillance clinics or to Hospital Eye Services.
OBJECTIVES:
To determine whether personalised screening intervals are cost-effective.
DESIGN:
Risk factors were identified in Gloucestershire, UK using survival modelling. A probabilistic decision hidden (unobserved) Markov model with a misgrading matrix was developed. This informed estimation of lifetime costs and quality-adjusted life-years (QALYs) in patients without STDR. Two personalised risk stratification models were employed: two screening episodes (SEs) (low, medium or high risk) or one SE with clinical information (low, medium-low, medium-high or high risk). The risk factor models were validated in other populations.
SETTING:
Gloucestershire, Nottinghamshire, South London and East Anglia (all UK).
PARTICIPANTS:
People with diabetes in Gloucestershire with risk stratification model validation using data from Nottinghamshire, South London and East Anglia.
MAIN OUTCOME MEASURES:
Personalised risk-based algorithm for screening interval; cost-effectiveness of different screening intervals.
RESULTS:
Data were obtained in Gloucestershire from 12,790 people with diabetes with known risk factors to derive the risk estimation models, from 15,877 people to inform the uptake of screening and from 17,043 people to inform the health-care resource-usage costs. Two stratification models were developed: one using only results from previous screening events and one using previous screening and some commonly available GP data. Both models were capable of differentiating groups at low and high risk of development of STDR. The rate of progression to STDR was 5 per 1000 person-years (PYs) in the lowest decile of risk and 75 per 1000 PYs in the highest decile. In the absence of personalised risk stratification, the most cost-effective screening interval was to screen all patients every 3 years, with a 46% probability of this being cost-effective at a £30,000 per QALY threshold. Using either risk stratification models, screening patients at low risk every 5 years was the most cost-effective option, with a probability of 99-100% at a £30,000 per QALY threshold. For the medium-risk groups screening every 3 years had a probability of 43-48% while screening high-risk groups every 2 years was cost-effective with a probability of 55-59%.
CONCLUSIONS:
The study found that annual screening of all patients for STDR was not cost-effective. Screening this entire cohort every 3 years was most likely to be cost-effective. When personalised intervals are applied, screening those in our low-risk groups every 5 years was found to be cost-effective. Screening high-risk groups every 2 years further improved the cost-effectiveness of the programme. There was considerable uncertainty in the estimated incremental costs and in the incremental QALYs, particularly with regard to implications of an increasing proportion of maculopathy cases receiving intravitreal injection rather than laser treatment. Future work should focus on improving the understanding of risk, validating in further populations and investigating quality issues in imaging and assessment including the potential for automated image grading
Public sector pricing policies : a review of Bank policy and practice
Get PDFNearly a decade has passed since the Bank codified its position on cost recovery policies (OMS 2.25) for public sector projects. In a review of 13 sectors, the authors find that the Bank guidelines are followed fairly closely in seven sectors: coal, irrigation, oil/gas, power, roads, telecommunications, and water/sewerage. In the other six sectors the focus is heavily on either distributional (health, education, housing) or financial (fertilizer, ports, railways) concerns - with little attempt to incorporate economic pricing principles. Efficiency pricing is not irrelevant or impossible in these sectors, and - even if used only as a benchmark - could improve sector management and project selection and design.Environmental Economics&Policies,Economic Theory&Research,Health Monitoring&Evaluation,Public Sector Economics&Finance,Banks&Banking Reform
