3,933 research outputs found
Gu Xiong : The River
No full textGu Xiong’s installation “The River” is described by O’Brian as a meditation on migrancy and displacement. The author situates the work within the life of the artist, who left China because of political oppression, and the history of the Canadian West, which has marginalized its Chinese inhabitants. Short poetic texts by Gu Xiong in which he identifies with spawning salmon are included. Biographical notes. 19 bibl. ref
Gu-4 suppresses affinity and avidity modulation of CD11b and improves the outcome of mice with endotoxemia and sepsis.
No full textBACKGROUND: Systemic leukocyte activation and disseminated leukocyte adhesion will impair the microcirculation and cause severe decrements in tissue perfusion and organ function in the process of severe sepsis. Gu-4, a lactosyl derivative, could selectively target CD11b to exert therapeutic effect in a rat model of severe burn shock. Here, we addressed whether Gu-4 could render protective effects on septic animals. METHODOLOGY/PRINCIPAL FINDINGS: On a murine model of endotoxemia induced by lipopolysaccharide (LPS), we found that the median effective dose (ED50) of Gu-4 was 0.929 mg/kg. In vivo treatment of Gu-4 after LPS challenge prominently attenuated LPS-induced lung injury and decreased lactic acid level in lung tissue. Using the ED50 of Gu-4, we also demonstrated that Gu-4 treatment significantly improved the survival rate of animals underwent sepsis induced by cecal ligation and puncture. By adhesion and transwell migration assays, we found that Gu-4 treatment inhibited the adhesion and transendothelial migration of LPS-stimulated THP-1 cells. By flow cytometry and microscopy, we demonstrated that Gu-4 treatment inhibited the exposure of active I-domain and the cluster formation of CD11b on the LPS-stimulated polymorphonuclear leukocytes. Western blot analyses further revealed that Gu-4 treatment markedly inhibited the activation of spleen tyrosine kinase in LPS-stimulated THP-1 cells. CONCLUSIONS/SIGNIFICANCE: Gu-4 improves the survival of mice underwent endotoxemia and sepsis, our in vitro investigations indicate that the possible underlying mechanism might involve the modulations of the affinity and avidity of CD11b on the leukocyte. Our findings shed light on the potential use of Gu-4, an interacting compound to CD11b, in the treatment of sepsis and septic shock
Deng Erya jiu cang jia gu.
No full text李宗焜拓摹并題."鄧爾雅(一八八四-一九五四)舊藏甲骨. 一九六九年五月鄧祖玄奉母葉多福女士之命以其父爾雅先生所藏甲骨慨贈香港中文大學聯合書院. 二〇一五年夏移藏大學圖書館""乙未仲冬余應香港中文大學圖書館李露絲館長之邀為館藏甲骨之儲存與展示貢愚余以坐言不如起行遂為之董理重為類次並施拓摹携歸裱冊而還之且識數語以記因緣李宗焜於史語所""Deng Erya (yi ba ba si - yi jiu wu si) jiu cang jia gu. Yi jiu liu jiu nian wu yue Deng Zuxuan feng mu Ye Duofu nü shi zhi ming yi qi fu Erya xian sheng suo cang jia gu kai zeng Xianggang Zhong wen da xue Lian he shu yuan. Er ling yi wu nian xia yi cang Da xue tu shu guan""Yi wei zhong dong yu ying Xianggang Zhong wen da xue tu shu guan Li Lusi guan zhang zhi yue wei guan cang jia gu zhi chu cun yu zhan shi gong yu yu yi zuo yan bu ru qi xing sui wei zhi dong li chong wei lei ci bing shi tuo mo xie gui biao ce er huan zhi qie shi shu yu yi ji yin yuan Li Zongkun yu Shi yu suo"In accordion binding.Li Zongkun tuo mo bing ti
Woulda, coulda, shoulda: The evaluation and the impact of the alternative outcome
No full textThe alternative outcome refers to the outcome of the unselected option in decision-making tasks, which has significant influence on the chosen outcome evaluation. Most paradigms have presented the alternative outcome either after or simultaneous with the chosen outcome, which complicates the observation on the brain activity associated with the alternative outcome. To circumvent this perceived shortcoming, we modified the classic paradigm designed by Yeung and Sanfey (2004) such that the alternative outcome was presented before the chosen outcome in each trial while an electroencephalogram was recorded. The feedback-related negativity (FRN) elicited by the positive alternative outcome was larger than that elicited by the negative alternative outcome, suggesting that the participants evaluated the positive alternative outcome as negative feedback. Moreover, the FRN and the P3 elicited by the chosen outcome were influenced by the valence of the alternative outcome. The current study reveals that the alternative outcome is treated as important information even though it is economically neutral
Effects of Gu-4 on activation of Syk in LPS stimulated THP-1 cells.
No full text<p>A: Western Blot analyses of Syk and phosphorylated Syk (p-Syk) in THP-1 cells stimulated with LPS alone (100 ng/ml), LPS (100 ng/ml) plus Gu-4 (40 nmol/ml), or Gu-4 alone (40 nmol/ml) for 0 to 20 mins; β-actin serves as a loading control. B: The densitometric analyses showed that LPS-induced increase of phosphorylation of Syk was markedly blocked by Gu-4. These statistical data were from 5 independent experiments. *: p<0.05 <i>vs.</i> the LPS + Gu-4 or Gu-4 treated group at indicated time point. #: p<0.05 <i>vs.</i> time point of 0 min.</p
Recent advances in the treatment of non-alcoholic fatty liver disease with astragaloside IV
No full textHUI WANG, YUNQIN JIANG, SHIYUN WANG, CHANCHAN LU, LUMIN TANG, TINGTING GU and SHU SHI
[email protected]
TCM Department, Shanghai Punan Hospital of Pudong New District, Shanghai, China
Accepted June 5, 2025
Published online June 6, 2025
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder that has become a global health challenge. With the lack of effective FDA-approved treatments, alternative therapies are being explored. Astragaloside IV (AS-IV), a bioactive compound derived from the plant Astragalus membranaceus (Fisch. ex Bunge) (Fabaceae/Leguminosae), native to Inner Mongolia and Siberia, has shown significant therapeutic potential in NAFLD. This review discusses the pharmacological effects and molecular mechanisms of AS-IV, highlighting its role in improving insulin resistance, regulating lipid metabolism, reducing oxidative stress and modulating inflammation. AS-IV acts through key molecular pathways, such as AMPK, Nrf2 and SREBP-1c, to mitigate liver steatosis and inflammation. Additionally, AS-IV influences gut microbiota and bile acid metabolism, contributing to its therapeutic effects. Despite promising results from preclinical studies, clinical data supporting AS-IV's efficacy in NAFLD treatment are limited. Future research should focus on clinical trials, pharmacokinetics, and the combination of AS-IV with other therapeutic agents to optimise its therapeutic potential and reduce side effects
Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews
No full textDrug addiction is viewed as a maladaptive memory induced by contextual cues even in the abstinent state. However, the variations of hedonia and appetite induced by the context during the abstinence have been neglected. To distinguish the representative behaviors between hedonia and appetite, micro-behaviors in abstinent animal such as psycho-activity and drug seeking behaviors were observed in morphine conditioned place preference (CPP). To confirm the different effects of reward between drug and natural reward, a palatable food CPP paradigm was compared in current work. After a 10-day training in CPP with morphine or food, the preference was tested on day 1, 14, 28, and the changes of micro-behaviors were analyzed further. Our data showed that tree shrews treated with morphine performed more jumps on day 1 and more visits to saline paired side on day 28, which indicated a featured behavioral transition from psycho-activity to seeking behavior during drug abstinence. Meanwhile, food conditioned animals only displayed obvious seeking behaviors in the three tests. The results suggest that the variations of micro-behaviors could imply such a transition from hedonic response to appetitive behaviors during morphine abstinence, which provided a potential behavioral basis for further neural mechanism studies
Han dai Gu wen shang shu jing zi yan jiu
No full textBased on these fragments, this dissertation first makes an attempt to clarify the issues involving the Gu Wen Shang Shu that was discovered in the Kong's wall, as reported in various documents of the Han Dynasty. It then proceeds to discuss the characteristics and the origins of the "archaic scripts" in the Shuo-wen Jie-zi and the Stone Classics in Three Scripts of the Wei Dynasty, as these two texts and the script of Gu Wen Shang Shu are closely related.Finally, by examining the discrepancies between the quotations of the Shang Shu in the Shuo-wen Jie-zi and the version of Ma Rong and Zheng Xuan, this dissertation constructs the argument that such discrepancies are perhaps the result of the interpretative replacement of characters which was, after all, a common method of teaching employed by gu wen scholars of the Eastern Han.It further deals with the argument of the "li-shu" transliteration (li gu ding), and through a detailed analysis of the expressions and terms used in the text, it expounds the view that the li-shu transliteration of the Gu Wen Shang Shu was non-existent in the Han Dynasty, let alone a so called li-shu transliterated version.Seeking to challenge this viewpoint, the author of this dissertation has made a close examination of the Gu Wen Shang Shu and has discovered that it was actually written in "li-shu", rather than in archaic script. Through a survey of relevant philological issues, the arguments are presented in this dissertation.The controversy surrounding the opposition between the archaic and vernacular scripts (jin gu wen) of the Han Dynasty is one of the most complex issues in Chinese philology. Scholars have yet to come to a consensus on which script the Gu Wen Shang Shu (The Book of History Written in Archaic Script) was written. For a long time, a popular view has been that the difference between "jin wen" (vernacular script: li-shu) and "gu wen" (archaic script) lies in the types of script used, as the so-called Gu Wen Shang Shu is believed to have been written in archaic script.The issue of script of Gu Wen Shang Shu has been a significant topic in Chinese philology. Moreover, the controversy over the archaic script and the contemporary script of the Han Dynasty is very much about the Shang Shu. An understanding of this issue is crucial in resolving problems confronting other archaic texts.Though the original text of the Gu Wen Shang Shu is no longer extant, there are a few surviving fragments in the quotations of the Shang Shu in the Shuo-wen Jie-zi, the "archaic scripts" in the Stone Classics in Three Scripts (San-ti Shi-jing), the "li-shu" transliteration (li gu ding) of the Shang Shu and the quotations of the Gu Wen Shang Shu of Ma Bong and Zheng Xuan in the Jin-dian Shi-wen.蘇春暉.論文(哲學博士)--香港中文大學, 2007.參考文獻(p. i-xvi).Adviser: Chan Hung Kan.Source: Dissertation Abstracts International, Volume: 69-01, Section: A, page: 0198.Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.Abstracts in Chinese and English.School code: 1307.Lun wen (zhe xue bo shi)--Xianggang Zhong wen da xue, 2007.Can kao wen xian (p. i-xvi).Su Chunhui
The Ancient Chinese Concepts of Shang 商 and Gu 賈 : Their Meaning and Historical Background
No full textIt has popularly been understood that the characters shang 商 and gu 賈 which express ideas of commerce and merchants can be separated in meaning such that shang refers to itinerant merchants (xingshang 行商) and gu refers to stationary merchants or shopkeepers (zuogu 坐賈). However, they cannot be restricted to these meanings. They were at times used interchangeably, and each author had a particular tendency in their usage. Moreover, in the Qin and Han periods, the words gu and guren 賈人 were technical terms used in legal documents to indicate commerce and merchants respectively. Without regard to this actual situation in his own time, Ban Gu 班固. in the Commerce chapter of his work "Explanations of the White Tiger Palace." asserted that shang meant "moving" (xing 行) and gu meant "stationary" (zhi 止). This was because he only considered the description recorded in the Zuozhuan and the Zhouli. His commerce chapter was written with the intention of showing that the Old Text Theory was superior to the competing New Text Theory. At the end of the Later Han, the idea that shang meant "itinerant" and gu meant "stationary" became an established theory due to the work of Zheng Xuan 鄭玄. Nevertheless, this distinction was not strictly followed even in later periods. In these periods, technical terms in legal documents indicating merchants changed from shanggu 商賈 in the Wei and Jin to just Shang in the Six Dynasty period. This latter term was then inherited by the Sui and Tang
On Local Zeta Integrals
No full textGu, Dalin.Thesis M.Phil. Chinese University of Hong Kong 2016.Includes bibliographical references (leaves ).Abstracts also in Chinese.Title from PDF title page (viewed on …)
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