622 research outputs found
Monocentric Relationship Management (MRM) and Mcorebrain™: Defining the Single AI Paradigm Beyond CRM (Version 3.0)
Get PDFThis concept note introduces Monocentric Relationship Management (MRM) — an AI-native paradigm defining a single accountable AI controller that autonomously governs the entire relationship lifecycle beyond CRM.
Unlike traditional enterprise architectures that fragment intelligence across sales, marketing, pricing, contract management, credit decisioning, billing, entitlements, compliance, and service, MRM unifies them under one closed-loop cognitive system.
The framework integrates autonomy and governance through policy-as-code, human-in-the-loop oversight, and continuous learning. It reframes relationship management as an integrated control problem, where predictive and prescriptive intelligence operate within explicit safety, ethical, and compliance boundaries.
Version 3.0 expands the foundational model by introducing the Mcorebrain™ — the autonomous cognitive nucleus of MRM that interprets natural-language prompts, validates them against policy constraints, and autonomously constructs operational systems, including data models, logic, and user interfaces.
This release defines a prompt-driven generation model, connecting business intent, governance policy, and system execution in one unified, accountable framework.
Previous version:
Javanbakht, A.H. (2025). Monocentric Relationship Management: Defining the Single AI Paradigm Beyond CRM (v2.0). DOI: 10.5281/zenodo.17209903
License: Creative Commons Attribution 4.0 International (CC BY 4.0)
Author: Aydin Habibi Javanbakht — Berlin, Germany
DOI (this version): 10.5281/zenodo.1733476
VLF-R studies in the Agora of Magnesia archaeological site, Aydin, Turkey
No full textVery low frequency wave-resistivity (VLF-R) method has been widely used for near surface and archaeological prospection over the last two decades. Shallow buried structures that show resistivity variation with respect to a surrounding medium could be determined with VLF-R. It is also a particularly rapid and cost-effective technique for collecting data on large-scale exploration. VLF-R studies were carried out in the Agora of Magnesia archaeological site (Aydin, Turkey) in order to determine the location and depth of ruins of the temple of Zeus. After performing theoretical studies to test the inversion algorithm, apparent resistivity and phase data were collected with three different frequencies and a laterally constrained two-layer inversion process was applied to each station. In addition to the inversion of all profiles for each frequency, all lines were stacked within a precise resistivity interval to obtain a 3D view of the structure. An excavation site is recommended after achieving the location of the temple
Nurse-led support impact via a mobile app for breast cancer patients after surgery: a quasi-experimental study (step 2)
No full textBreast cancer patients may experience some health issues following surgery. Training patients about self-care plays a vital role in managing these symptoms. Mobile applications are a contemporary and appropriate approach to support patients about the potential symptoms following breast cancer surgery. This quasi-experimental study aimed to assess the impact of nurse-led support mobile application (NL-Mapp) delivered on breast cancer patients after surgery. Ninety participants were recruited, with 45 assigned to the intervention group and 45 to the control group. Subjects in the intervention group received NL-Mapp in addition to routine care, while those in the control group received only routine care over four weeks. The intervention included educational content on the postoperative period of breast cancer. Outcomes were assessed at baseline (M0), before discharge (M1), and one month after surgery (M2). The intervention group patients had significantly improved pain, affected shoulder functions, and anxiety owing to the effects of group, time, and group-time interaction. Body image and sexual adjustment were enhanced based on time and group-time interaction effects. During the follow-up period, experimental group patients experienced an improvement in body image and sexual adjustment, while those in the control group showed a decrease. This suggests that NL-Mapp may play a significant role in training breast cancer patients to manage their symptoms after surgery. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.3916444
Microfluidic diagnostics from continuous liquid interface production additive manufacturing
Get PDFBiomedical diagnostics based on microfluidic devices have the potential to significantly benefit human health, however the manufacturing of microfluidic devices is a key limitation to their widespread adoption. Additive manufacturing (AM) is an attractive alternative to conventional approaches for microfluidic device manufacturing based on injection molding, however, there is a need for development of new manufacturing process capabilities and materials that are compatible for microfluidic diagnostics. In this thesis, we investigate process characteristics and capabilities of continuous liquid interface production (CLIP) based AM, focusing on aspects relevant for microfluidic device manufacturing, and validation of the materials as used in a applications of bacterial detection. We find that CLIP accurately produces microfluidic channels as small as 400 m, and that it is possible to routinely produce fluid channels as small as 100 m with high repeatability but with somewhat lower accuracy. Print orientation significantly affects the accuracy and repeatability of the process, and the best accuracy is achieved when the microchannels are parallel to the direction of motion of the build tray. We demonstrate manufacturing, assembly and packaging, and application of a microfluidic device made using CLIP for detection of E. coli bacteria using a process based on loop-mediated isothermal amplification at 65 °C. The methodology introduced in this this could be used to investigate and validate other AM process for microfluidic diagnostics, and the research highlights key issues and capabilities for CLIP and other resin-based AM processes.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-08-01The student, Mehmet Aydin, accepted the attached license on 2020-07-20 at 11:16.The student, Mehmet Aydin, submitted this Thesis for approval on 2020-07-20 at 11:38.This Thesis was approved for publication on 2020-07-23 at 09:03.DSpace SAF Submission Ingestion Package generated from Vireo submission #15694 on 2020-10-02 at 15:51:48Made available in DSpace on 2020-10-07T22:50:06Z (GMT). No. of bitstreams: 3
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Life satisfaction of counsellor supervisees: the role of counselling self-efficacy, trait anxiety and trait hope
No full textThe aim of the present study is to investigate the role of counselling self-efficacy, trait anxiety and trait hope in life satisfaction of novice counsellor supervisees. The sample group consisted of 360 female, 199 male and 11 undergraduate counsellors who were unwilling to report gender. Data collection tools included the Personal Information Form, the CASES, the STAI-T, The Hope Scale and the SWLS. A hypothetical structural model was developed and tested for the fit to the data. According to research findings, counselling self-efficacy was found to have a significant indirect effect on life satisfaction through trait anxiety and trait hope. Trait anxiety and trait hope were concluded to have direct effects on life satisfaction of novice counsellor supervisees.Karadeniz Technical University [SYL-2016-5475]This study was supported by Karadeniz Technical University with the code of SYL-2016-5475 and granted 1977,09 Turkish Liras. We couldn't see this information anywhere in the article. This study is produced from master's thesis of the corresponding author, Fatih Aydin. Is it possible to note it somewhere? Full details of the thesis are: Aydin, F. (2016). Effect of counseling self-efficacy, hope and anxiety on life satisfaction among counselor candidates (Unpublished master's thesis). Karadeniz Technical University, Trabzon
Potential antiproliferative and apoptotic effects of pilocarpine combined with TNF alpha in chronic myeloid leukemia cells
No full text© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Pilocarpine is a selective M1/M3 agonist of muscarinic acetylcholine receptor subtypes. Muscarinic acetylcholine receptors are G protein-coupled receptors. These receptors are different drug targets. The aim of the present work was to investigate the effect of pilocarpine on the expression of M3 muscarinic acetylcholine receptor, the AChE activity, IL-8 release response, and proliferation in K562 cells, via muscarinic receptor activation. Human chronic myeloid leukemic cell cultures were incubated with drugs. Proliferation assays were performed by BrdU assay. Expression of M3 muscarinic acetylcholine receptor and apoptosis proteins such as bcl, bax, cyt C, and caspases was assessed with the semiquantitative Western blotting method. Pilocarpine inhibits chronic myeloid cell proliferation and M3 muscarinic acetylcholine receptor protein expression. Pilocarpine increases caspase-8 and -9 expression levels, upregulating the proapoptotic protein Bax and downregulating the expression levels of the antiapoptotic protein Bcl-2. The apoptotic activity of pilocarpine is associated with an increase in AChE activity. M3 muscarinic acetylcholine receptors can activate multiple signal transduction systems and mediate inhibitory effects on chronic myeloid K562 cell proliferation depending on the presence of 1% FBS conditions. This apoptotic effect of pilocarpine may be due to the concentration of pilocarpine and the increase in AChE level. Our results suggest that inhibition of cell proliferation by inducing apoptosis of pilocarpine in K562 cells may be one of the targets. M3 selective agonist may have therapeutic potential in chronic myeloid leukemia. Graphical Abstract: [Figure not available: see fulltext.]
Возникновение и развитие Эмирата Айдын в первой трети XIV века
No full textThe processes of emergence and development of the Emirate of Aydin in the rst third of the XIV century is revealed by the author in this article. The author considers political and economic development of the Emirate of Aydin in the context of its international relations with European Eastern Mediterranean states
Возникновение и развитие Эмирата Айдын в первой трети XIV века
No full textThe processes of emergence and development of the Emirate of Aydin in the rst third of the XIV century is revealed by the author in this article. The author considers political and economic development of the Emirate of Aydin in the context of its international relations with European Eastern Mediterranean states
LAKOFF VE JOHNSON’IN METAFOR KURAMI VE ESKİ TÜRKÇE İLE ORTA TÜRKÇEDE BİRLEŞİK FİİLLERDE YÜK METAFORU
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