180 research outputs found
Three essays in applied econometrics
No full textThis dissertation presents three essays which are linked by the use of econometric models to explain problems that are only explained descriptively in the literature. The first essay, statistically shows that a systematic measurement bias can significantly distort predictions obtained using an international accounting framework due to the sizable diversity of the parties involved in it. Once the measurement bias is taken into account, the average value gains on the US foreign asset and liability categories are estimated to be smaller, and no evidence is found on positive yield differential. The second essay estimates the value gains and the mismeasurement using data at multiple frequencies. The results show that positive sizable return differential is present after 2002. The third essay shows that the increasing availability of prescription opioids threatens sellers' profit margin since it is a close substitute for heroin and forces sellers to find alternative methods to compensate buyers in the case of a negative supply shock.Ph.D.Includes bibliographical referencesIncludes vitaby Emel Oylum Yildiri
Synthesis, spectroscopic characterization and DFT calculations of novel Schiff base containing thiophene ring
No full textWOS: 000425075900011In this study, a new Schiff base derivative, 2-[(2-hydroxy-5-thiophen-2-yl-benzylidene)-amino]-6-methyl-benzoic acid (5), which has a thiophene ring and N, O donor groups, was successfully prepared by the condensation reaction of 2-hydroxy-5-(thiophen-2-yl)benzaldehyde (3) and 2-amino-6-methylbenzoic acid (4). The characterization of a Schiff base derivative (5) was performed by experimentally the UV-Vis., FTIR, H-1 and C-13 NMR spectroscopic methods and elemental analysis. Density Functional Theory (DFT/B3LYP/6-311+G(d, p)) calculations were used to examine the optimized molecular geometry, vibrational frequencies, H-1 and C-13 NMR chemical shifts, UV-Vis. spectroscopic parameters, HOMO-LUMO energies and molecular electrostatic potential (MEP) map of the compound (5) and the theoretical results were compared to the experimental data. In addition, the energetic behaviors such as the sum of electronic and thermal free energy (SETFE), atomic charges, dipole moment of the compound (5) in solvent media were investigated using the B3LYP method with the 6-311+G(d, p) basis set. The obtained experimental and theoretical results were found to be compatible with each other and they were supported the proposed molecular structure for the synthesized Schiff base derivative (5)Anadolu University Scientific Research Projects (BAP) [1705F213]; BAP [1102F027, 1304F064]; [1306F110]This study was supported by Anadolu University Scientific Research Projects (BAP) through project 1705F213. The author also gratefully thank to BAP for supporting Gaussian 09 and Gauss View 5.0 programs with the projects (Project No 1102F027 and 1304F064) and its financial support for Agilent DD2 NMR Spectrometer (Project No. 1306F110)
Assessment of implication of competitiveness on human development of countries through data envelopment analysis and cluster analysis
No full textFüsun Ülengin (Dogus Author) -- Özgür Kabak (Dogus Author) -- Şule Önsel (Dogus Author) -- Emel Aktaş (Dogus Author)Globalization speeds up competition among nations in various sectors. In terms of multinational and transnational phenomena, countries are seen as inescapable from competition, thus the linking of the term global with "competitiveness." The research described here explores the relationship between the competitiveness of a country and its implications for human development. For this purpose, using data envelopment analysis (DEA) and cluster analysis, 44 selected countries were evaluated. An output-oriented super-efficiency model where global competitiveness indicators are taken as input variables with human development indicators as output variables is utilized. Then cluster analysis depending on the competitiveness and human development indicators is conducted by using self-organizing maps to specify the development levels of the countries. Both analyses are repeated for years between 2005 and 2007. Finally, the relationship between the super efficiency scores and the development levels is analyzed
The Analysis of Conceptual Studies On Contemporary Ceramics Art in Light of Peter Osborne's Conceptual Art Initiative
No full textSanat olgusu ortaya çıktığı dönemden günümüze değin yapılan pek çok sanat eseriyle farklı nitelik ve yorumlar kazanarak gelişmiştir. Bu gelişmeler ve dönüşümler sonucunda 20.yüzyılın ikinci yarısından itibaren içerisinde bulunduğumuz dönem postmodern olarak adlandırılmakta ve sanatın sonu şeklinde değerlendirilmektedir.Sanatta yaşanan bu büyük dönüşümler pek çok disiplini olduğu gibi seramik sanatını da etkilemiştir. Seramik sanatı 19.yüzyıl ve sonrası sanayi devriminden sonra gelişen teknoloji ve farklılaşan kültürel yapılarla, 20.yüzyılda sanatsal bir disiplin olarak kabul görmüştür. Bu süreçte çağdaş seramik sanatçılarının yorumlarıyla, kavrama yönelik eserler ortaya konmuştur.Kavramsal Sanat ise temelinde düşüncenin yapıta üstünlüğü fikrini barındıran Postmodern dönem içerisinde büyük bir kırılma yaratmış olan bir eğilimdir. Kavramsal sanat, seramik sanatının evrensel nitelik kazanmasına, geleneksel ve modernist uslüba karşı duran kavramsal seramik eserler üretilmesine olanak sağlaması bakımından seramik sanat tarihinde önemli bir yere sahiptir. Postmodernizmin eklektik yapısıyla birleşen kavramsal seramik eserler çağın gerçekliklerinin kavranmasını kolaylaştırırken, geçmişle bağ kurarak belgesel bir nitelik taşımaktadır. Bu çalışmada, çağdaş seramik sanatında, sanat anlayışında bir dönüm noktası olan kavramsal sanatın önemi ve seramik sanatına katkıları felsefe profesörü ve yazar Peter Osborne'nin kavramsal sanat açılımı doğrultusunda incelenmektedir.Ever since it emerged to present, the art fact has developed by getting different qualities and comments with many art works. As a result of these developments and transformations, the period which we are in since the second half of the 20th century is called Postmodernism and considered to be end of the art These efficient transformations as influenced the ceramic art as many disciplines. In the 20th century, ceramic art has been accepted as an artistic discipline with the 19th century and later by industrial revolution, the developing of technology and differing cultural structures. In this process, conceptual art works were created by contemporary ceramic artists' interpretations. Conceptual art is a trend which created a big break in the postmodern period, which is based on the idea that is thought, has superiority to the art work. In the ceramic art history, conceptual art history has an important place because of enabling of the creating ceramic art works which stands against the traditional and the modernist style. Conceptual ceramic art works, which combine with eclectic nature of postmodernism, has a documentary feature by establishing a link with the past while make it easy to grasp realities of era. In this study, the importance of conception art, which is a milestone in the art conception and its contributions to ceramic art, are examined according to philosophy professor and author Peter Osborne's conceptual art initiative
Toward Compilation of Balanced Protein Stability Data Sets: Flattening the G Curve through Systematic Enrichment
No full textOften studies analyzing stability
data sets and/or predictors ignore
neutral mutations and use a binary classification scheme labeling
only destabilizing and stabilizing mutations. Recognizing that highly
concentrated neutral mutations interfere with data set quality, we
have explored three protein stability data sets: S2648, PON-tstab,
and the symmetric Ssym that differ in size and quality.
A characteristic leptokurtic shape in the ΔΔG distributions of all three data sets including the curated and symmetric
ones was reported due to concentrated neutral mutations. To further
investigate the impact of neutral mutations on ΔΔG predictions, we have comprehensively assessed the performance
of 11 predictors on the PON-tstab data set. Correlation and error
analyses showed that all of the predictors performed the best on the
neutral mutations, while their performance became gradually worse
as the ΔΔG of the mutations departed
further from the neutral zone regardless of the direction, implying
a bias toward dense mutations. To this end, after unraveling the role
of concentrated neutral mutations in biases of stability data sets,
we described a systematic enrichment approach to balance the ΔΔG distributions. Before enrichment, mutations were clustered
based on their biochemical and/or structural features, and then three
mutations were selected from every 2 kcal/mol of each cluster. Upon
implementation of this approach by distinct clustering schemes, we
generated five subsets varying in size and ΔΔG distributions. All subsets showed improved ΔΔG and frequency distributions. We ultimately reported that
the errors toward enriched subsets were higher than those toward the
parent data sets, confirming the enrichment of difficult-to-predict
mutations in the subsets. In summary, we elaborated the prediction
bias toward a concentrated neutral zone and also implemented a rational
strategy to tackle this and other forms of biases. Ultimately, this
study equipping us with an extended view of shortcomings of stability
data sets is a step taken toward development of an unbiased predictor
Thermostability of the PYL–PP2C Heterodimer Is Dependent on Magnesium: <i>In Silico</i> Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants
No full textAFFIPred: AlphaFold2 structure\u2010based Functional Impact Prediction of missense variations
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