419 research outputs found
Museum
No full textRenowned poet, Paula Meehan and award-winning photographer, Dragana Jurišić have joined forces to create a book celebrating the varied history of, and the lives lived in, 14 Henrietta Street, Dublin’s museum of social history. The book, entitled ‘MUSEUM’, was launched by author Roddy Doyle on Thursday, 25th July at the former Georgian townhouse in Dublin’s north inner city
Containing the Kalon Kakon: The Portrayal of Women in Ancient Greek Mythology
No full textAbout the Author
Dessa Meehan recently finished her undergraduate degree (Magna cum Laude) at Western Washington University double majoring in History and Anthropology-Archaeology. She also minored in Geographic Information Science, Arabic and Islamic Studies, and Latin. Her research interests center around comparative women studies in classical civilizations, especially within the Roman Empire. She will continue her education in the MSt Classical Archaeology program at University of Oxford during the 2017-2018 academic year, with the eventual goal of obtaining PhD and leading archaeological excavations
First Impression: An Interview With Author and Bibliophile Nicholas A. Basbanes
No full textNicholas A. Basbanes did not publish his first book until he was 52 but, in the ten years since, the former literary editor at the Worcester Sunday Telegram has given bibliophiles and librarians five books about books. The first, A Gentle Madness: Bibliophiles, Bibliomanes, and the Eternal Passion for Books (Holt, 1995), was a landmark commentary on book collecting that has sold 100,000 copies. The second, Patience & Fortitude (HarperCollins, 2001), named for the pair of lions that guard the entrance to the New York Public Library, explored the ways librarians and collectors have protected and housed their treasures throughout history, while describing libraries and book culture in general. Next came Among the Gently Mad: Strategies and Perspectives for the Book-Hunter in the 21st Century (Holt, 2002), a spin-off book from the first book. Arriving after that was A Splendor of Letters: The Permanence of Books in an Impermanent World (HarperCollins, 2003), an expanded section intended for Patience & Fortitude that looked at how books are preserved for succeeding generations. Borrowing from Ranganathan's third law of library science, Basbanes' recent book, Every Book Its Reader (HarperCollins, 2005), allowed him to draw on numerous taped interviews conducted for A Gentle Madness that were never used. His next work will be a centennial history of Yale University Press. The Lowell, Massachusetts, native spoke at Indiana University as a guest of its Medieval Studies Institute in October 2005, when William F. Meehan III sat down with the author at the Grant Street Inn in Bloomington
First Impression: An Interview With Author and Bibliophile Nicholas A. Basbanes
No full textNicholas A. Basbanes did not publish his first book until he was 52 but, in the ten years since, the former literary editor at the Worcester Sunday Telegram has given bibliophiles and librarians five books about books. The first, A Gentle Madness: Bibliophiles, Bibliomanes, and the Eternal Passion for Books (Holt, 1995), was a landmark commentary on book collecting that has sold 100,000 copies. The second, Patience & Fortitude (HarperCollins, 2001), named for the pair of lions that guard the entrance to the New York Public Library, explored the ways librarians and collectors have protected and housed their treasures throughout history, while describing libraries and book culture in general. Next came Among the Gently Mad: Strategies and Perspectives for the Book-Hunter in the 21st Century (Holt, 2002), a spin-off book from the first book. Arriving after that was A Splendor of Letters: The Permanence of Books in an Impermanent World (HarperCollins, 2003), an expanded section intended for Patience & Fortitude that looked at how books are preserved for succeeding generations. Borrowing from Ranganathan's third law of library science, Basbanes' recent book, Every Book Its Reader (HarperCollins, 2005), allowed him to draw on numerous taped interviews conducted for A Gentle Madness that were never used. His next work will be a centennial history of Yale University Press. The Lowell, Massachusetts, native spoke at Indiana University as a guest of its Medieval Studies Institute in October 2005, when William F. Meehan III sat down with the author at the Grant Street Inn in Bloomington
Top-down cortical interactions in visuospatial attention
No full textThe voluntary allocation of visuospatial attention depends upon top-down influences from the frontal eye field (FEF) and intraparietal sulcus (IPS)-the core regions of the dorsal attention network (DAN)-to visual occipital cortex (VOC), and has been further associated with within-DAN influences, particularly from the FEF to IPS. However, the degree to which these influences manifest at rest and are then modulated during anticipatory visuospatial attention tasks remains poorly understood. Here, we measured both undirected and directed functional connectivity (UFC, DFC) between the FEF, IPS, and VOC at rest and during an anticipatory visuospatial attention task, using a slow event-related design. Whereas the comparison between rest and task indicated FC modulations that persisted throughout the task duration, the large number of task trials we collected further enabled us to measure shorter timescale modulations of FC across the trial. Relative to rest, task engagement induced enhancement of both top-down influences from the DAN to VOC, as well as bidirectional influences between the FEF and IPS. These results suggest that task performance induces enhanced interaction within the DAN and a greater top-down influence on VOC. While resting FC generally showed right hemisphere dominance, task-related enhancement favored the left hemisphere, effectively balancing a resting hemispheric asymmetry, particularly within the DAN. On a shorter (within-trial) timescale, VOC-to-DAN and bidirectional FEF-IPS influences were transiently elevated during the anticipatory period of the trial, evincing phasic modulations related to changing attentional demands. In contrast to these task-specific effects, resting and task-related influence patterns were highly correlated, suggesting a predisposing role for resting organization, which requires minimal tonic and phasic modulations for control of visuospatial attention
Establishing methods for analysis of DNA methylation in breast cancer and cell-free circulating DNA
No full textBreast cancer is the most common cancer in women worldwide. To date,
diagnosis and metastasis monitoring are mainly carried out through tissue
biopsy, a very invasive procedure limited only to certain locations and not
always feasible in clinical practice. Tumour cells release DNA into the blood as
circulating cell-free DNA (cfDNA), which can be sampled from circulating blood,
an approach known as liquid biopsy. This provides a resource for biomarkers
that could allow the use of minimally invasive liquid biopsies for cancer-related
research, diagnostics, prognostics, and targeted therapy. The levels of cfDNA
have already been shown to be higher in cancer individuals than healthy
individuals, and correlate with tumour metastasis, response to therapy and
recurrence. Recent technological advances have enabled the identification of
both genetic and epigenetic aberrations in cfDNA that reflect changes also
found in patients’ tumours. The host group performed methylation analysis
using the Illumina EPIC Methylation Array, which interrogated CpG dinucleotide
methylation at over 850,000 DNA sites. A total of 3172 CpGs showed median
methylation differences of more than 40% between tumour and buffy coat of
patients with breast cancer. This MRes project aimed to establish methods for
detecting these methylation changes between matched tumour samples and
leucocytes of breast cancer patients, and in cfDNA by using the Fluidigm 48.48
Access Array microfluidics system and the Illumina MiSeq sequencer. This
approach provided quantitative, medium-throughput targeted measurement of
DNA methylation at single nucleotide resolution. Finally, bisulfite
pyrosequencing was used as a sensitive validation technique for detecting
differences in CpG methylation, providing a set of potential biomarkers that
could be reliably detected by circulating tumour DNA-based tests. Translating
the alterations that are seen in the primary tumour into an assay that is
applicable to cfDNA will have important diagnostic implications, such as
monitoring tumour progression, drug response and disease recurrence, as well
as the early detection of cancer, which could ultimately complement or even
avoid the need for tumour tissue biopsies
The Bass-less Trio
No full textMiles Davis asserts in his autobiography, that "a great artist needs to be able to stretch" [Davis, Troup, 1990]. While I may not a great artist, I aspire to make art with my music, and in my own musical journey I have been interested in trying out new ideas. Jazz musicians, because of their various skills (and in particular, in the art of improvisation) find themselves straddling musical boundaries and genres, just to pay the rent. In my own projects however, this musical adroitness was born just as much out of artistic curiosity as it was necessity, leading me to compose and perform in a variety of contexts and styles for a broad range of instrumentation. These contexts and styles include: duos for saxophone and piano accordion; Bach sonatas with string ensembles; improvising live dance music with DJs; organ trios; in electronica contexts; art and poetry collaborations. The need for creativity has expressed itself in all of my work, to varying degrees. On reflection, it's the need to create something new and fresh out of work and ideas that are already explored to some extent. This desire is consistent with the jazz legacy I have inherited. In much the way Louis Armstrong began transforming popular songs into jazz vehicles, Charles Mingus took ideas from older African American musical traditions and transformed them to offer a fresh perspective on those traditions, and Miles Davis borrowed ideas from rock and soul music to pioneer new directions in jazz during the 1960s and 1970s, I too am looking for new avenues of expression for jazz musicians
Prevalence, incidence and risk factors of epilepsy in older children in rural Kenya.
No full textBACKGROUND: There is little data on the burden or causes of epilepsy in developing countries, particularly in children living in sub-Saharan Africa. METHODS: We conducted two surveys to estimate the prevalence, incidence and risk factors of epilepsy in children in a rural district of Kenya. All children born between 1991 and 1995 were screened with a questionnaire in 2001 and 2003, and those with a positive response were then assessed for epilepsy by a clinician. Active epilepsy was defined as two or more unprovoked seizures with one in the last year. RESULTS: In the first survey 10,218 children were identified from a census, of whom 110 had epilepsy. The adjusted prevalence estimates of lifetime and active epilepsy were 41/1000 (95% CI: 31-51) and 11/1000 (95% CI: 5-15), respectively. Overall two-thirds of children had either generalized tonic-clonic and/or secondary generalized seizures. A positive history of febrile seizures (OR=3.01; 95% CI: 1.50-6.01) and family history of epilepsy (OR=2.55; 95% CI: 1.19-5.46) were important risk factors for active epilepsy. After the second survey, 39 children from the same birth cohort with previously undiagnosed epilepsy were identified, thus the incidence rate of active epilepsy is 187 per 100,000 per year (95% CI: 133-256) in children aged 6-12 years. CONCLUSIONS: There is a considerable burden of epilepsy in older children living in this area of rural Kenya, with a family history of seizures and a history of febrile seizures identified as risk factors for developing epilepsy
Do Managed Mutual Funds Perform Better than their Respective Indexes on a Risk- Adjusted Basis?
No full textChange in narrative therapy : a pragmatic hermeneutic case study
No full textThe client of this case study was a twenty two year old female in her first year at university. The
client had come into therapy because she had felt depressed, lonely and riddled with selfdoubt.
The author used a Narrative Therapy approach with the client and was focussed on
helping the client generate new meanings and stories that were more useful and empowering
for the client. In this case study, the author was interested in exploring the process of change
that the client underwent during the therapy process and he would rely on identifying
innovative moments to track these changes. This interest informed the research question; what
is the process of change in narrative therapy as tracked through the therapeutic dialogue? How
does the change process in this case study track with the heuristic model of change put forward
by Gonçalves and his colleagues? The author chose to use a pragmatic hermeneutic case study
method in order to analyse the data and the results were organised into a coherent narrative.
The data was collected from twenty two therapy sessions and these were grouped together
into themes, namely a quick start, the beginning of change, thickening the innovative moments
and lighting the fire. The results of this study reveal that despite being considered a good
outcome case by the author, the process of change differed somewhat to that proposed by the
heuristic model of change
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