371 research outputs found
DS_773045 – Supplemental material for Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth
No full textSupplemental material, DS_773045 for Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth by Linas J. Krulikas, Ian M. McDonald, Benjamin Lee, Denis O. Okumu, Michael P. East, Thomas S. K. Gilbert, Laura E. Herring, Brian T. Golitz, Carrow I. Wells, Allison D. Axtman, William J. Zuercher, Timothy M. Willson, Dmitri Kireev, Jen Jen Yeh, Gary L. Johnson, Antonio T. Baines, and Lee M. Graves in SLAS Discovery</p
Hepatic encephalopathy associated with cancer or anticancer therapy
No full textHepatic encephalopathy is an uncommon cause of neurologic deterioration associated with hyperammonemia, which results from hepatic dysfunction or altered ammonia metabolism. Often overlooked, hyperammonemia may occur via any of several pathophysiological processes, and in the setting of malignancy, it is a potentially reversible cause of confusion and coma. Hepatic dysfunction as a result of malignant infiltration, chemotherapeutic toxicities, targeted anticancer therapies, reactivation hepatitis, portosystemic shunting, and transarterial chemoembolization (TACE) is discussed, and an approach to etiological diagnosis and management is outlined.Kaspar J. Willson, Louise M. Nott, Vy T. Broadbridge, Timothy Pric
Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
No full textWe report the identification of substituted cis-bicyclo[3.3.0]oct-2-enes as small molecule agonists of subfamily V orphan nuclear receptors (NR5A), liver receptor homolog-1 (LRH-1) and steroidogenic factor-1 (SF-1). Using fluorescence resonance energy transfer (FRET)-based biochemical assays, compound 5a (GSK8470) was identified as a high-affinity ligand for LRH-1 and SF-1. In liver cells, 5a increased the expression of the LRH-1 target gene small heterodimer partner (SHP). Synthesis of analogues modified at three positions led to the development of compounds with functional selectivity between LRH-1 and SF-1
Bridging the indigenous gulf
No full textThe author examines the politics of amending the Australian Constitution. Topics include relation relations, indigenous people, and government policies
A Meta-analysis of the Relationship Between Sexual Victimization and Risk Perception: A Review from 1990 to 2013.
No full textSexual victimization is a growing problem among women. Sexual victimization can be described as an event where an individual undergoes an unwanted sexual experience. There are many factors that could increase a woman���s risk for sexual victimization. One of the most important factors is risk perception. Risk perception is embedded in the way individuals perceive, interpret, and react to a risky situation. Sexual victimization and risk perception has been an area of focus for many during the past few years. Although, there is a large body of evidence in this area, many of the studies are inconsistent and currently only one literature review exists. Therefore, there is a need for a meta-analysis study to try to understand the sexual victimization and risk perception relationship from a quantitative perspective, as well as to detect the types of moderator variables that may influence it.
This study sought to analyze and synthesize the empirical findings of the relationship between sexual victimization and risk perception from 1990 through March 2013. A secondary goal is to better understand the relationship between sexual victimization and risk perception. A tertiary purpose was to understand the moderating influence of a number of factors on this relationship. Consistent with the guidelines and procedures for a meta-analysis set forth by Cooper in 2010, 51 studies were identified producing a total 116 effect sizes. These effect sizes were not calculated independently. Instead, the effect sizes from each study were averaged in order to form a mean effect size per study. The mean effects were then averaged to form the omnibus mean effect size.
The omnibus mean effect size from the 51 studies was of g = 0.167, p < .001, demonstrating a small-sized effect. This effect size was more modest in magnitude; however, it demonstrated a relationship between sexual victimization and risk perception. All the moderators with the exception of alcohol and design quality were significant contributors to the variance in the effect sizes. In addition to examining the omnibus mean effect size and potential moderators, limitations and implications for practice and future research were discussed
Effect Size Matters: Empirical Investigations to Help Researchers Make Informed Decisions on Commonly Used Statistical Techniques
No full textThe present journal article formatted dissertation assessed the characteristics of effect sizes of commonly used statistical techniques. In the first study, the author examined the American Educational Research Journal (AERJ) and select American Psychological Association (APA) and American Counseling Association (ACA) journals to provide an historical account and synthesis of which statistical techniques were most prevalent in the fields of education and psychology. These reviews represented a total of 17,698 techniques recorded from 12,012 articles. Findings point to a general decrease in the use of the tvtest and ANOVA/ANCOVA and a general increase in the use of regression and factor/cluster analysis.
In the second study, the author compared the efficacy of one Pearson r2 and seven multiple R2 correction formulas for the Pearson r2. The author computed adjustment bias and precision under 108 conditions (6 population p2 values, 3 shape conditions and 6 sample size conditions). The Pratt and the Olkin-Pratt Extended formulas more consistently provided unbiased estimates across sample sizes, p2 values and the shape conditions investigated.
In the third study, the author evaluated the robustness of estimates of practical significance (n2, e2 and w2) in one-way between subjects univariate ANOVA. There were 360 simulation conditions (5 population Cohen's d values, 4 group proportion ratios, 3 shape conditions, 3 variance conditions, and 2 total sample size conditions) for each of three group configurations (2, 3 and 4 groups). Three indices of practical significance (n2, e2, w2) and two indices of statistical significance (Type I error and power) were computed for each of the 5,400, 000 (5,000 replications x 360 simulation conditions x 3 group configurations). Simulation findings for n2 under heterogeneous variance conditions indicated that for the k=2 and k=3 condition Cohen's d values up to 0.2 (up to 0.5 for k=4) tend to produce overestimated population n2 values. Under heterogeneous variance conditions for e2 and w2 at Cohen's d = 0.0 and 0.2, the negative variance pairing overestimated and the positive variance pairing underestimated the parameter n2 but at Cohen's d greater than or equal to 0.5, both the positive and negative variance conditions resulted in underestimated parameter n2 values
A power sharing series power BJT array with isolated low voltage control for AC power control applications
No full textA technique for a continuously variable AC resistance using a series BJT array is presented. This array provides high power dissipation capability and uniform voltage and power distribution across the individual transistors. The array, controlled using a set of optoisolators to maintain the electrical isolation between the control circuits and the power stage, could be used as the basis to develop several useful techniques including a solid state AC regulator with comparable performance to the commonly used ferro-resonant systems; a linear AC electronic load suitable for testing UPS and other power conditioners; and, in other AC power control applications such as switching capacitors in AC resonant circuits
Correlates of mother-infant attachment : a meta-analysis
No full textTypescript (photocopy).A meta-analysis was conducted to review and integrate the findings of the mother-infant attachment literature. Standardizing differences for secure and anxiously attached infants from 89 studies yielded 809 outcome values. Across all variables and study types, 90% of the effects were positive, and the average effect size was +0.63, indicating that securely attached infants display more favorable outcomes than do those who are anxiously attached. Maternal characteristics were two-thirds of a standard deviation greater for secure than for anxiously attached infants. Infant attributes overall demonstrated a mean effect size of 0.59, with physical aspects elevated for securely attached infants 0.03, temperament 0.55, cognitive/intellectual aspects 0.47, social 0.78, and emotional 0.66. Mother-infant interaction and behaviors of the mother toward her infant and of the infant toward the mother were more positive for securely attached infants, demonstrating effect sizes of 0.70, 0.66, and 0 .83, respectively. Situations were more favorable for securely attached infants by one-half of a standard deviation. Antecedent studies showed an effect size of +0.77. Concurrent measurement of attachment and its correlated variables produced an effect size of +0.39. Security of mother-infant attachment was predictive of favorable outcomes with a resultant effect size value of +0.71. Many of the methodological factors coded were determined to contribute to the findings of this meta-analysis. Sex and race of the subjects, source and time of publication, sample size, type of measure, setting, study type, subdivision (or not) of the anxious attachment group, number of contrasts, test statistic used, significance level of the result, and training of the author were related to effect size, either practically, statistically, or both. Subjects' ages and sociometric status statement (or not) of attachment group sizes, and technique were unrelated..
When nursing the elderly doesn't end at work: caregivers' narratives in the paid and unpaid spheres
No full textCaregiving to the elderly in both the paid and unpaid spheres involves a crucial component, emotion management, that is often invisible despite its importance to the delivery of care. As well, little is known about how caregivers’ emotion management in one setting is related to its expression in another. This thesis is an exploration to gain a greater understanding of the ways in which the contexts of caregiving shape the emotion management involved, in hopes of contributing to the knowledge of an important dimension of caregiving and women’s work in the two spheres.
Based on the narratives of women who work as caregivers in both the paid and unpaid spheres simultaneously, I use a socialist-feminist perspective to analyze the ideology and structure that shape contexts in which emotion management occurs in caregiving. I explore how these contexts affect the experience of emotion management, and how the contexts might impact one another and the emotion management performed in each.Master of Scienc
The Need for Meta-Analytic Thinking in Educational Technology Research
No full textThe present journal article formatted dissertation assessed the extent of meta-analytic thinking currently used educational technology research. In the first study, the author examined the journals, Computers & Education, International Journal of Computer-Supported Collaborative Learning, British Journal of Educational Technology, Australasian Journal of Educational Technology, and Educational
Technology Research and Development, between 2012 and 2013 to offer empirical evidence of the field���s current status with regard to reporting results using meta-analytic thinking. These articles represented a total of 32,131 research methods and statistical techniques recorded from 1,171 articles. Findings point to little change in how educational technology researchers conduct investigations. Quantitative methods continue to dominate the field as a whole. Most authors reported the type of sampling procedure used in their investigations. Few researchers reported score reliability estimates using their own data. Findings also suggest few authors report informationally-adequate statistics. One area of concern is the tendency to report a mean without the SD
about the mean. Another area of concern is the lack of reporting correlation matrices with accompanying means and standard deviations or covariance matrices.
In the second study, the author conducted a meta-analysis to offer a glimpse of where the field could go once researchers begin to think meta-analytically. The author cumulated findings from nine studies which used the Technology Acceptance Model (TAM) to explain undergraduate students��� acceptance of online learning. The author used meta-analytic structural equation modeling and multiple-group analysis to test four path models. The meta-analytic findings suggest the TAM is not a valid theoretical model to explain undergraduates��� acceptance of college online courses. The multiple group analysis emphasized that the parameter estimates between studies resulted in statistically different findings, suggesting the findings across studies are not replicable
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