2,214 research outputs found
Design and Implementation of Functional Nanoelectronic Interfaces With Biomolecules, Cells, and Tissue Using Nanowire Device Arrays
No full textNanowire FETs (NWFETs) are promising building blocks for nanoscale bioelectronic interfaces with cells and tissue since they are known to exhibit exquisite sensitivity in the context of chemical and biological detection, and have the potential to form strongly coupled interfaces with cell membranes. We present a general scheme that can be used to assemble NWs with rationally designed composition and geometry on either planar inorganic or biocompatible flexible plastic surfaces. We demonstrate that these devices can be used to measure signals from neurons, cardiomyocytes, and heart tissue. Reported signals are in millivolts range, which are equal to or substantially greater than those recorded with either planar FETs or multielectrode arrays, and demonstrate one unique advantage of NW-based devices. Basic studies showing the effect of device sensitivity and cell/substrate junction quality on signal magnitude are presented. Finally, our demonstrated ability to design high-density arrays of NWFETs enables us to map signal at the subcellular level, a functionality not enabled by conventional microfabricated devices. These advances could have broad applications in high-throughput drug assays, fundamental biophysical studies of cellular function, and development of powerful prosthetics
‘Through the unknown, remembered gate’: the Brian Nettleton lecture – Outdoors Victoria conference, 2022
No full textThis paper is an adapted version of the Brian Nettleton Lecture given at the Outdoors Victoria Conference, 2022. It explores how the last two decades have seen an ever-accelerating Digital Revolution which has impacted on almost every aspect of human experience to the point that it is now omnipresent. Life is now mediated through the screen. As a result, children and young people have become hyper-vigilant, overly anxious, experience a sense of climate trauma, and have decreasing access to, and time spent in, the outdoors. In addition, children have just experienced two years of isolation as a result of the Covid-19 pandemic and evidence suggests that they are already experiencing significant mental health issues as a result. This paper considers the implications of this for Outdoors Victoria and Outdoor Education. © The Author(s) 2023
Partitioning of gases to ice in the atmosphere: effects on nitric acid and the formation of sulfate
No full textThis thesis describes the first implementation of gas-to-ice partitioning of three inorganic gases (HNO3, SO2 and H2O2), along with subsequent chemical reactions and changes in gas phase and particle mass concentrations in the Community Multiscale Air Quality (CMAQ) chemical transport model. Adsorbed HNO3 was assumed to condense and partition to the aerosol phase. Adsorbed SO2 and H2O2 reacted to form sulfate on the ice surface. Four different simulations were performed with CMAQv4.7.1 for August 12th-25th of 2005: 1) base case simulation without the addition of lightning-generated NOx, 2) a simulation with the addition of lightning-generated NOx, 3) 100% partitioning case and 4) 25% partitioning case. Simulations 3) and 4) provided an upper and lower bound for the partitioning of adsorbed HNO3 to remain in the aerosol phase. Considerable decreases, greater than 25% in gas phase HNO3, were noted in the 100% partitioning case for 200-600 mb, with the largest changes at 300 mb and 400 mb. Potential effects induced on other gases in the nitrogen budget (NOx and HONO) and oxidant cycling of atmosphere (O3) due to gas-to-ice partitioning of HNO3 were considered. Decreases in NOx and HONO gas mixing ratios were found to be as high 20%, but were generally less than 10%. Changes in O3 concentration were less than 1%. Increases in nitrate aerosol mass concentration were as high as 0.15 µg/m3 for the upper levels of the atmosphere. No changes in H2O2, SO2, or sulfate aerosol concentrations were observed.M.S.Includes bibliographical referencesby Brian P. Marm
Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release
No full textAuthor Manuscript 2012 March 9.Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on−off drug release upon application (and removal) of an oscillating magnetic field. We show that the dose of drug delivered across the membrane can be tuned by engineering the phase transition temperature of the nanogel, the loading density of nanogels in the membrane, and the membrane thickness, allowing for on-state delivery of model drugs over at least 2 orders of magnitude (0.1−10 μg/h). The zero-order kinetics of drug release across the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500−40000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.Ruth L. Kirschstein National Research Service AwardNational Institutes of Health (U.S.) (Award F32GM096546
In Honour of Brian MacWhinney: A Personal Account
No full textWhile this volume and the writings have made it amply clear what significant contributions Professor Brian MacWhinney has made to the field at large, in this afterword, we begin with a senior member of our author team (Ping Li, PL) followed by a mid-career member (Helen Zhao, HZ) and an early career member (Zhe Gao, ZG), to provide our personal accounts of Brian not only as a leading scholar but also as a role model who touches and changes people’s lives
70th Anniversary of the Bombing of Darwin
No full textOn 20th February 2012, I was sitting next to Brian Winspear at the Commemoration Ceremony. Brian Came up from Tasmania, to lay a wreath for No. 2 Squadron (Hudson's) RAAF. Name WINSPEAR, ROGER BRIAN
Service Royal Australian Air Force
Service Number 408126
Date of Birth 26 Sep 1920
Place of Birth BURNIE, TAS
Date of Enlistment 6 Dec 1940
Locality on Enlistment Unknown
Place of Enlistment HOBART
Next of Kin WINSPEAR, R
Date of Discharge 26 Nov 1945
Rank Flight Lieutenant
Posting at Discharge 100 SQUADRON
Brian has written 2 books:
My backseat war / Brian Winspear.
Author Winspear, Brian.
Published [Rosny Park, Tas.] : B. Winspear, 21 cm.
Physical Description 78 p. : ill. ; 21 cm.
Tasmania's at war in the air, 1939-1945 / edited by Sue Johnson and Brian Winspear.
Other Authors Johnson, Sue.
Winspear, Brian.
Published Rosny Park, Tas. : B. Winspear, c2002.Richards, Joh
Cognition and visual information: an examination of human evolution, cognitive models and my artistic practice
No full textAn examination of my cross-disciplinary artistic practice that attempts to bring together Asian meditative disciplines with Western inquiry through visualizing social and physical statistics. As I explore the relationship between language and sensation, I use Charles Pierce's three referential modes: the iconic, indexical and symbol-symbol to view how humanity as come to understand the world through images, objects and rituals. Paralleling this investigation is a systems theory that attempts to visualize the fluidity of a non-discrete universe where social interaction correlates with the physical world.M.F.A.Includes bibliographical references (p. 39-42)by Brian J Bulfe
Brian Massumi, The Politics of Affect
No full textThe Politics of Affect By: Brian Massumi Description Buy book / Order Exam Copy Reviews Table of Contents Author Information ShareThis Description 'The capacity to affect and to be affected'. This simple definition opens a world of questions - by indicating an openness to the world. To affect and to be affected is to be in encounter, and to be in encounter is to have already ventured forth. Adventure: far from being enclosed in the interiority of a subject, affect concerns an immediate p..
Brian Massumi, The Politics of Affect
No full textThe Politics of Affect By: Brian Massumi Description Buy book / Order Exam Copy Reviews Table of Contents Author Information ShareThis Description 'The capacity to affect and to be affected'. This simple definition opens a world of questions - by indicating an openness to the world. To affect and to be affected is to be in encounter, and to be in encounter is to have already ventured forth. Adventure: far from being enclosed in the interiority of a subject, affect concerns an immediate p..
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