59 research outputs found
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[Memoirs]: Colin Trevor Pillinger. 9 May 1943—7 May 2014
No full textColin Pillinger was a larger-than-life planetary scientist with an infectious enthusiasm for science. He was a founding member of the Planetary and Space Sciences Research Institute at the Open University in Milton Keynes. He was a mass spectroscopist who applied these techniques with great success to the study of extraterrestrial rock samples from both meteorites and the Moon. He helped identify a class of meteorite found on Earth that originated from Mars. In turn, this led to leadership of the Beagle 2 Mars lander project, which was designed to take scientific instruments to Mars in order to search for evidence of past life. Against all odds, the landing on Mars was successful, but communication with the lander was never established. Colin was a brilliant innovator, both in his science and in adopting a somewhat unconventional approach to funding the ambitious Beagle 2 project. He enjoyed the fact that, even though it was possible to purchase off-the-shelf instrumentation, the truly creative aspect of his analytic method was in the details of how it was applied, for which the rule book was still being written. Throughout his career he continued to ride the wave of new developments and was always keen to push the limits. He was a brilliant communicator, always full of engaging enthusiasm
metomi/rose: Rose 2.4.1 [CODE]
No full textSee CHANGES.md for details.Matt Shin, Ben Fitzpatrick, Andrew Clark, Oliver Sanders, Tim Pillinger, Ronnie Dutta, Sadie L. Bartholomew, Stuart Whitehouse, David Matthews, Stephen Oxley, Tomek Trzeciak, Declan Valters, Hilary James Oliver, Joe Mancell, Melanie Hall, Tom Coleman, Harry Shepherd, Annette Osprey, Jon Seddon, … Paul Cresswell. (2025). metomi/rose: Rose 2.4.1 (2.4.1). Zenodo. https://doi.org/10.5281/zenodo.1492530
metomi/rose: Rose 2.3.2
No full textSee CHANGES.md for details.Matt Shin, Ben Fitzpatrick, Andrew Clark, Oliver Sanders, Tim Pillinger, Ronnie Dutta, Sadie L. Bartholomew, Stuart Whitehouse, David Matthews, Stephen Oxley, Tomek Trzeciak, Declan Valters, Hilary James Oliver, Joe Mancell, Melanie Hall, Tom Coleman, Harry Shepherd, Annette Osprey, Jon Seddon, … Paul Cresswell. (2024). metomi/rose: Rose 2.3.2 (2.3.2). Zenodo. https://doi.org/10.5281/zenodo.1409637
metomi/rose: Rose 2.4.2
No full textSee CHANGES.md for details.Matt Shin, Ben Fitzpatrick, Andrew Clark, Oliver Sanders, Tim Pillinger, Ronnie Dutta, Sadie L. Bartholomew, Stuart Whitehouse, David Matthews, Stephen Oxley, Tomek Trzeciak, Declan Valters, Hilary James Oliver, Joe Mancell, Melanie Hall, Tom Coleman, Harry Shepherd, Annette Osprey, Jon Seddon, … Paul Cresswell. (2025). metomi/rose: Rose 2.4.2 (2.4.2). Zenodo. https://doi.org/10.5281/zenodo.1516921
metomi/rose: Rose 2.4.0
No full textSee CHANGES.md for details.Matt Shin, Ben Fitzpatrick, Andrew Clark, Oliver Sanders, Tim Pillinger, Ronnie Dutta, Sadie L. Bartholomew, Stuart Whitehouse, David Matthews, Stephen Oxley, Tomek Trzeciak, Declan Valters, Hilary James Oliver, Joe Mancell, Melanie Hall, Tom Coleman, Harry Shepherd, Annette Osprey, Jon Seddon, … Paul Cresswell. (2025). metomi/rose: Rose 2.4.0 (2.4.0). Zenodo. https://doi.org/10.5281/zenodo.1462067
Increased rates of respiratory disease in schizophrenia: A systematic review and meta-analysis including 619,214 individuals with schizophrenia and 52,159,551 controls
No full textINTRODUCTION: Despite respiratory disease being a major cause of excess mortality in people with schizophrenia, the prevalence of respiratory conditions in this population is poorly defined. A systematic review and meta-analysis were conducted to establish the prevalence and association of respiratory diseases in people with schizophrenia. MATERIAL AND METHODS: Major electronic databases were searched from inception to 27 April 2020 for articles reporting respiratory disease (asthma, chronic obstructive pulmonary disease [COPD], pneumonia, and tuberculosis) in people with schizophrenia and, where possible, a control group. A random-effects meta-analysis was conducted. The study was registered with PROSPERO (CRD42018115137). RESULTS: Of 1569 citations, 21 studies consisting of 619,214 individuals with schizophrenia and 52,159,551 controls were included in the meta-analysis. Compared to the general population, people with schizophrenia had significantly higher rates of COPD (odds ratio [OR]: 1.82, 95% CI: 1.28-2.57), asthma (OR: 1.70, 95% CI: 1.02-2.83), and pneumonia (OR: 2.62, 95% CI: 1.10-6.23). In people with schizophrenia, the prevalence of COPD was 7.7% (95% CI: 4.0-14.4), asthma 7.5% (95% CI: 4.9-11.3), pneumonia 10.3% (95% CI 5.4-18.6), and tuberculosis 0.3% (95% CI 0.1 -0.8). After adjusting for publication bias, the prevalence of COPD increased to 19.9% (95% CI: 9.6-36.7). DISCUSSION: All respiratory diseases examined were significantly more prevalent in people with schizophrenia compared with the general population. Future studies should focus on improving the prevention and management of respiratory disease in this group to reduce associated excess mortality.sponsorship: We would like to thank Marc Miravitlles from Vall d'Hebron University Hospital and Research Institute for providing additional data. Brendon Stubbs is supported by a Clinical Lectureship (ICA-CL-201703-001) jointly funded by Health Education England (HEE) and the National Institute for Health Research (NIHR). Brendon Stubbs is part funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust. Brendon Stubbs also holds active grants with the Medical Research Council (GCRF and multimorbidity calls) and Guys and St Thomas Charity (GSTT). Toby Pillinger's work is supported by the NIHR and holds an active grant with the Maudsley Charity. GH is supported by the European Union's Horizon 2020 Research and Innovation Action Grant (847776). FG is in part supported by the NIHR Biomedical Research Centre at South London and Maudsley NHSFoundation Trust and King's College London, the Stanley Medical Research Institute, the Maudsley Charity and the NIHR Applied Research Collaboration South London (NIHR ARC South London) at King's College Hospital NHS Foundation Trust. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. (Health Education England (HEE)|ICA-CL-201703-001, National Institute for Health Research (NIHR)|ICA-CL-201703-001, NIHR Biomedical Research Centre at South London, Medical Research Council (GCRF and multimorbidity calls), Guys and St Thomas Charity (GSTT), Maudsley Charity, European Union|847776, NIHR Biomedical Research Centre at South London and Maudsley NHSFoundation Trust and King's College London, Stanley Medical Research Institute, NIHR Applied Research Collaboration South London (NIHR ARC South London) at King's College Hospital NHS Foundation Trust, Maudsley NHS Foundation Trust, National Institute for Health Research|ICA-CL-2017-03-001)status: Publishe
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Febuxostat and Cardiovascular Events: A Systematic Review and Meta-Analysis
No full textBackground. Febuxostat is approved in the United States for the management of hyperuricemia in patients with gout. In November 2017 the FDA released a warning alert on a possible link between febuxostat and cardiovascular disease (CVD) reported in a single clinical trial. Objective. To conduct a systematic review and meta-analysis and assess the risk of major adverse cardiovascular events (MACE) in patients receiving febuxostat compared to a control group. Methods. We searched the MEDLINE and EMBASE database for studies published up until March 2018. We included randomized clinical trials (RCTs) that compared febuxostat to control groups including placebo and allopurinol. We calculated the pooled relative risk (RR) of MACE and cardiovascular disease (CVD) mortality with the corresponding 95% confidence intervals (CI). Results. Our search yielded 374 potentially relevant studies. Among the 25 RCTs included in the systematic review, 10 qualified for the meta-analysis. Among the 14,402 subjects included, the median age was 54 years (IQR 52-67) and 90% were male (IQR 82-96); 8602 received febuxostat, 5118 allopurinol, and 643 placebo. The pooled RR of MACE for febuxostat was 0.9; 95% CI 0.6-1.5 (p= 0.96) compared to the control. The RR of CV-related death for febuxostat was 1.29; 95% CI 1.01-1.66 (p=0.03). Conclusions. Compared with other SU-lowering treatments, febuxostat does not increase or decrease the risk of cardiovascular disease but may increase the risk of CVD death. More RCTs measuring cardiovascular safety as a primary outcome are needed to adequately evaluate the risk of CVD with febuxostat
The Early Byzantine Domed Basilicas of West Asia Minor, An essay in Graphic Reconstruction
Get PDFThis paper investigates the methodology employed in the recent survey and reconstruction of the major Early Byzantine domed churches of west Asia Minor. This involved both the documentation of construction details as well as their interpretation by reference to coeval monuments elsewhere. Focusing on this methodology, the author explores techniques of graphic recording and the theoretical framework within which parallels with other buildings can inform the work of reconstruction. The detailed examination of two case studies illustrates the way in which seemingly random scraps of testimony were interpreted to provide evidence for the missing superstructure of the churches. These case studies also serve to explore the adaptation of the methodology to sites with different characteristics and help to assess the credibility of the resulting graphic reconstructions
a Creating a list of missingness patterns in
No full textFrequently the data we analyse will be incomplete, with some cases lacking observations for some variables. It is generally useful to investigate this phenomenon, and one part of this investigation may be to examine the patterns of missingness among the variables of interest. For example, it may be that there are a few variables which are either all observed or all missing for most cases. It is very easy in MLwiN to produce a list of the patterns of missingness which appear in the data, with a record of how many cases have each pattern. A note on the example data The data which appear in the screenshots in this document demonstrating the process are taken from the US National Collaborative Perinatal Project (NCPP) 1. They are in the public domain and can be found at ftp://sph-ftp.jhsph.edu/cpp / 2, together with extensive documentation. Here we use a subset consisting of all twins who survived at least to age 8. The variables used have been renamed by the present author for ease of use. They consist of the zygosity of the twin pair (zygosity), a sex variable created by the present author using all the variables recording sex available in the data (so as to reduce the missingness of sex as far as possible; sex), the age when the WISC and WRAT were administered (age), the sex variable from the same dataset as the WISC and WRAT (sex7), scores for the three WRAT tests spelling, reading and arithmetic, raw full scale WISC score (FS), WISC full scale IQ (FSIQ), raw WISC verbal score (verbal), WISC verbal IQ (verbalIQ), raw WISC performance score (perf), WISC performance IQ (perfIQ), parental education (e7), occupation (o7) and income (i7) when the twins were age 7, and two different codings of parental education (e01 and e02), occupation (o01 and o02) and income (i01 and i02) at registration into the study (before the birth of the twins). Checking missingness is recorded correctly First we make sure that after importation to MLwiN, all the values that represent missingness have been recoded to MLwiN’s missing value. Depending on how the data have been imported and what values were used for missingess in the original dataset, this may have 1 The L ATEX example table at the end of the document is not based on the real data
Joint annual meeting of Lunar Exploration Analysis Group-International Conference on Exploration and Utilization of the Moon-Space Resources Roundtable.
No full textThis CD-ROM contains the contents, program, abstracts, and author indexes for the Joint Annual Meeting of LEAG-ICEUM-SRR.sponsored by Lunar and Planetary Institute ... [and others]Conveners: Clive Neal, University of Notre Dame, Steve Mackwell, Lunar and Planetary Institute, Bernard Foing, European Space Agency, International Lunar Exploration Working Group, Leslie Gertsch, Missouri University of Science and Technology.PARTIAL CONTENTS: Plans for Involving the Commercial Sector in Space Exploration / K. Davidian--Models for the Lunar Radiation Environment / G. De Angelis, F. F. Badavi, S. R. Blattnig, J. M. Clem, M. S. Clowdsley, R. K. Tripathi, and J. W. Wilson--High Resolution Maps of the Moon Surface with AMIE/SMART-1 / D. Despan, S. Erard, A. Barucci, J.-L. Josset, S. Beauvivre, S. Chevrel, P. Pinet, D. Koschny, M. Almeida, B. Grieger, B. H. Foing, and AMIE Team--Contract Incentives for an Open Architecture International Lunar Network Including Google Lunar X-Prize / D. A. Dunlop--International Lunar Observatory Association (ILOA): 3 Mission Update — ILO-X Precursor, ILO-1 Polar, ILO Human Service Mission / S. Durst--What Astrobiology Investigations are Needed and Possible on the Moon? / P. Ehrenfreund and B. H. Foing--Lunar Crater Observation and Sensing Satellite (LCROSS) Science Payload Ground Development, Test, and Calibration / K. Ennico, A. Colaprete, J. Heldmann, G. Kojima, D. Lynch, M. Shirley, and D. Wooden--Geologic Preparation for Exploring the Moon and Planets: Using the Past as a Key to the Present / D. B. Eppler--Report from ILEWG on Science and Exploration Questions / B. H. Foing and the International Lunar Exploration Working Group--Improving Lunar Surface Science with Robotic Recon / T. Fong, M. Deans, P. Lee, J. Heldmann, D. Kring, E. Heggy, and R. Landis--Lunar Beagle: A Science Package for Measuring Polar Ice and Volatiles on the Moon / E. K. Gibson, C. T. Pillinger, D. S. McKay, I. P. Wright, M. R. Sims, L. Richter, L. Waugh, and Lunar Beagle Consortium
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