617 research outputs found
Emerging Epigenetic and Posttranslational Mechanisms Controlling Resistance to Glucocorticoids in Acute Lymphoblastic Leukemia
No full textGlucocorticoids are extensively used for the treatment of acute lymphoblastic leukemia as they pressure cancer cells to undergo apoptosis. Nevertheless, glucocorticoid partners, modifications, and mechanisms of action are hitherto poorly characterized. This hampers our understanding of therapy resistance, frequently occurring in leukemia despite the current therapeutic combinations using glucocorticoids in acute lymphoblastic leukemia. In this review, we initially cover the traditional view of glucocorticoid resistance and ways of targeting this resistance. We discuss recent progress in our understanding of chromatin and posttranslational properties of the glucocorticoid receptor that might be proven beneficial in our efforts to understand and target therapy resistance. We discuss emerging roles of pathways and proteins such as the lymphocyte-specific kinase that antagonizes glucocorticoid receptor activation and nuclear translocation. In addition, we provide an overview of ongoing therapeutic approaches that sensitize cells to glucocorticoids including small molecule inhibitors and proteolysis-targeting chimeras
Getij in de Westerschelde: Verslag van de discussies op 14 oktober 1999
No full textDit rapport bevat het verslag van de workshop over het getij in de Westerschelde d.d. 14 oktober 1999. Het rapport bevat naast een weergave van de presentaties die gehouden zijn een verslag van de discussie. Op grond van de resultaten van de discussie is met Directie Zeeland overleg geweest over de te volgen aanpak voor vervolgstudies. Besloten is om de studie naar veiligheid en interactie morfologie en getij te splitsen. Tot nu toe is geprobeerd deze twee zaken in een studie te verenigen, hetgeen niet haalbaar gebleken is. Binnen het onderdeel veiligheid zal de aandacht vooral gericht zijn op de voortplanting van het getij onder extreme omstandigheden. Daartoe zullen een tweetal studies uitgevoerd worden. Bij het optreden van een extreme omstandigheid is de bodemgeometrie een gegeven. Deze zal in de loop der tijd door menselijke ingrepen en natuurlijke morfologische processen wel veranderen, waardoor ook de voortplanting van de hoogwatergolf anders zal zijn. Daarnaast zijn de hydraulische randvoorwaarden vanuit de Noordzee ook van belang voor de optredende hoogwaterstand. Welke van deze twee factoren het meest dominant is, is van belang voor vervolg onderzoek naar de toekomstige ontwikkeling van de hoogwaterstand. Omdat door menselijk ingrijpen de bodemgeometrie verandert, zal ook onderzoek nodig zijn naar de invloed van de bodemgeometrie op de voortplanting van de hoogwatergolf. Vragen die hierbij van essentieel belang zijn, zijn stijgen de extreme hoogwaterstanden als gevolg van de verruiming van de vaargeul en de zandwinning? En is er een soort omslagpunt denkbaar waarbij de bodem dusdanig veranderd is dat de extreme hoogwaters onevenredig snel stijgen? Deze twee studies zullen zo snel mogelijk in gang gezet worden. Daarnaast zal meer fundamenteel onderzoek naar de voortplanting van het getij m.b.v. 1 dimensionale modellen zoals op de workshop gepresteerd is door Dhr. Pieters, worden uitgevoerd. De resultaten van deze studie leveren een bijdrage aan zowel de studie naar veiligheid tegen overstromen als aan de studie naar interactie tussen getij en morfologie
PEARL TF-PV, thin-film modules, shunts and droplets
No full text# A training and testing dataset
The dataset contains labelled images of thin-film modules collected
during the PEARL project.
This dataset is used in this paper:
@article{sovetkin2020encoder,
title={Encoder-decoder semantic segmentation models for electroluminescence images of thin-film modules},
author={Sovetkin, Evgenii and Weber, Thomas and Achterberg, Elbert Jan and Pieters, Bart Elger},
journal={IEEE Journal of Photovoltaics},
year={2020},
}
## Structure of the data
The data is split onto 3 groups: training, testing and
final_evaluation. Each group contains labelled images for droplets and
shunts.
All images are located in "images" directory. All labelled images are
located in "labels" directory
Child's buccal cell mitochondrial DNA content modifies the association between heart rate variability and recent air pollution exposure at school
No full textBACKGROUND: Studies investigating short-term exposure to ambient air pollution and heart rate variability (HRV) suggest that particulate matter (PM) exposure is associated with reductions in measures of HRV. Mitochondria are sensitive to PM exposure and may represent a biologically relevant underlying mechanism. However, evidence in children is lacking. OBJECTIVES: Here we examine whether PM has an influence on children's HRV and evaluate whether mitochondrial DNA content (mtDNAc) reflects individual susceptibility. METHODS: Within a panel study in primary school children (aged 9-12 years), we measured HRV in a subset of 60 children on three different days during school-time using four indicators: normal-to-normal intervals (SDNN), square root of mean squared difference of normal-to-normal intervals (rMSSD), high frequency (HF), and low frequency (LF). This resulted in a total number of 150 visits (median number of visits per child: 2.5/child). MtDNAc was measured using qPCR in buccal cells. We measured recent PM exposure at the school. Residential 24-hour mean exposure to PM was modelled with a high resolution spatial temporal model. Mixed-effects models were used to estimate the association between HRV and recent PM exposure and potential effect-modification by mtDNAc. RESULTS: Children were on average [SD] 9.9 [1.2] years and comprised 39 girls. Median [25th-75th] recent outdoor PM2.5 and PM10 exposure at school was 6.20 [2.8-12.8] μg/m3 and 29.3 [24.7-42.0] μg/m3, respectively. In children with low mtDNAc (25th percentile), we observed for each 10 μg/m3 increment in recent PM2.5 exposure a lowering in the LF parameter with 9.76% (95% CI: -16.9 to -1.99%, p = 0.02; pint = 0.007). Children with high mtDNAc did not show this association. For PM10 exposure, we observed an inverse association with three HRV indicators in children with low mtDNAc: -2.24% (95% CI: -4.27 to -0.16%; p = 0.04; pint = 0.02) for SDNN, -5.67% (95% CI: -10.5 to -0.59%; p = 0.03; pint = 0.04) for HF and -6.64% (95% CI: -10.7 to -2.38%; p = 0.003; pint = 0.005) for LF. CONCLUSIONS: HRV is inversely associated with recent PM air pollution, especially in children with low mtDNAc. Our data revealed that mtDNAc determines susceptibility to adverse autonomic effects of recent PM exposure in children.sponsorship: This work was supported by the Research Foundation Flanders (FWO, G073315N/G.0873.11.N10) and European Research Council (ERC-2012-StG 310898). Eline B. Provost has a VITO-FWO PhD fellowship. Karen Vrijens has a FWO postdoctoral fellowship (12D7714N). (Research Foundation Flanders (FWO)|G073315N/G.0873.11.N10, European Research Council|ERC-2012-StG 310898, VITO-FWO, FWO|12D7714N)status: Publishe
Decreased placental mitochondrial DNA-content in response to air pollution during in utero life
No full textRecent studies have emphasized the importance of PM, and its associated metal components, in the formation of reactive oxygen species (ROS) and inflammation. Mitochondria are the major intracellular sources and primary targets of ROS. Mitochondrial DNA (mtDNA) is particularly vulnerable to ROS-induced damage, resulting in a higher mutation rate that impacts mitochondrial function. Given its multiple essential roles in metabolic pathways, mitochondrial dysfunction (i.e. change in mtDNA-content) is important in fetal development. In utero exposure to environmental factors may influence mitochondrial function which may comprise a mechanism of earlier onset of multifactorial disease such as cardiovascular disease in later life1
Decreased placental mitochondrial DNA-content in response to air pollution during in utero life
No full textRecent studies have emphasized the importance of PM, and its associated metal components, in the formation of reactive oxygen species (ROS) and inflammation. Mitochondria are the major intracellular sources and primary targets of ROS. Mitochondrial DNA (mtDNA) is particularly vulnerable to ROS-induced damage, resulting in a higher mutation rate that impacts mitochondrial function. Given its multiple essential roles in metabolic pathways, mitochondrial dysfunction (i.e. change in mtDNA-content) is important in fetal development. In utero exposure to environmental factors may influence mitochondrial function which may comprise a mechanism of earlier onset of multifactorial disease such as cardiovascular disease in later life1
Wasting a window of opportunity: Anticipated and experienced regret in intention-behavior consistency
No full textpreferences;voting;elections;regret theory
Book review : The constitutional courts of small jurisdictions
No full textThis volume helps to fill an important gap in legal literature that addresses not so much the mainstream constitutional courts but those of small jurisdictions about which little is written. Apart from the introduction and comparative conclusion, this book contains contributions on the constitutional courts of, in alphabetical order: Andorra (Willem Verrijdt), Cyprus (Polina Hadjimitsi), Estonia (Karin Leichter-Tammisto), Liechtenstein (Tim Souverijns), Luxembourg (Jean-Claude Wiwinius), Malta (Tim Souverijns), Monaco (Willem Verrijdt), Montenegro (Aleksandra Vukasinovic), and San Marino (Danny Pieters).peer-reviewe
The Quest for Citations: Drivers of Article Impact
No full textWhy do some articles become building blocks for future scholars, while many others remain unnoticed? We aim to answer this question by contrasting, synthesizing and simultaneously testing three scientometric perspectives – universalism, social constructivism and presentation – on the influence of article and author characteristics on article citations. To do so, we study all articles published in a sample of five major journals in marketing from 1990 to 2002 that are central to the discipline. We count the number of citations each of these articles has received and regress this count on an extensive set of characteristics of the article (i.e. article quality, article domain, title length, the use of attention grabbers and expositional clarity), and the author (i.e. author visibility and author personal promotion). We find that the number of citations an article in the marketing discipline receives, depends upon “what one says†(quality and domain), on “who says it†(author visibility and personal promotion) and not so much on “how one says it†(title length, the use of attention grabbers, and expositional clarity). Our insights contribute to the marketing literature and are relevant to scientific stakeholders, such as the management of scientific journals and individual academic scholars, as they strive to maximize citations. They are also relevant to marketing practitioners. They inform practitioners on characteristics of the academic journals in marketing and their relevance to decisions they face. On the other hand, they also raise challenges towards making our journals accessible and relevant to marketing practitioners: (1) authors visible to academics are not necessarily visible to practitioners; (2) the readability of an article may hurt academic credibility and impact, while it may be instrumental in influencing practitioners; (3) it remains questionable whether articles that academics assess to be of high quality are also managerially relevant.Impact;Citation Analysis;Referencing;Scientometrics;Cite
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