16,853 research outputs found

    No.432 Howard Smith

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    Transcript (38 pages) of interview by Tim Larson with Howard G. Smith, on June 24, 1986Smith discusses his career as an engineer at KSL, both in radio and television. Interviewer: Tim Larso

    Dr. Eleanor J. Smith Black History Collection

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    Doctor Eleanor J. Smith is an African American studies educator, musician, university system chancellor, author, and visual artist. Dr. Smith was faculty member of the University of Cincinnati’s Afro-American Studies Department and William Patterson University. After obtaining a doctorate in African American studies and becoming a university professor, Dr. Smith wrote and directed performances about the Black experience during the 1970s

    A Gisha

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    Doctor Eleanor J. Smith is an African American studies educator, musician, university system chancellor, author, and visual artist. Dr. Smith was faculty member of the University of Cincinnati’s Afro-American Studies Department and William Patterson University. After obtaining a doctorate in African American studies and becoming a university professor, Dr. Smith wrote and directed performances about the Black experience during the 1970s

    J. B. Smith Plumbing & Tinwork

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    J. B. Smith Plumbing and Tinwork postcard. Text on back: Well old scout. How are you both. Tell Emma I will write in a day or tow. We are all well. This is J. B. S. Jr. in shirt sleeve and a ___ (?) J. B. Smith it was addressed to Fred Fulmerl (?) Cincinnati, Ohio 1012 Tim Street.https://scholarsjunction.msstate.edu/mss-faulk-papers/1901/thumbnail.jp

    Interview with Annette J. Smith

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    Interview in seven sessions, December 2010 to January 2011 with Annette J. Smith, visiting professor of French at Caltech from 1970 to 1982, appointed associate professor with tenure in 1982, promoted to professor of French in 1985, and Professor of Literature emeritus since 1993. Family history, childhood and education in Algiers, Algeria. Family history and background of late husband, Caltech Professor of Literature David R. Smith (1960-1990). Bachelor’s degree in Classics (1948) from Sorbonne in Paris. Attended the School of Professors of French Abroad at the Sorbonne and taught at the University of Wales in Swansea. Master’s degree in English. Marriage to D. Smith and move to the United States. Teaches at Scripps College and Claremont Men’s College [now Claremont McKenna College], where she had tenure position. Caltech hires D. Smith as professor and A. Smith as lecturer in French language. D. Smith as Joseph Conrad scholar. Doctorate degree (1964) and dissertation on author Nicole Védrès. D. Smith made Master of Student Houses (1969-1975); life in Virginia Steele Scott house. Descriptions of faculty and atmosphere within Division of Humanities and Social Sciences (HSS), beginning when Hallett Smith was chair. Friendship with Max and Manny Delbrück. Cultural life at Caltech; D. Smith brings poets, actors, directors and musicians to campus. Life as professor’s spouse and efforts to improve working conditions and salaries for female staff. Sexual discrimination in HSS and support for Jenijoy La Belle. History and founding of Baxter Art Gallery (1970), significant exhibitions organized by D. Smith, closing of Baxter Art Gallery (1985). Important relationships with Caltech professors, postdocs and staff: R. Sperry, R. Feynman, A. Hibbs, J. and F. Audouze, D. and C. Cesarsky, J.-P. Bibring, and N. and C. Corngold. Elevated to associate professor (1982). Literature courses she taught and impressions of students. Two books accepted for publication: one on Arthur de Gobineau and translation of poems by Aimé Césaire. Explanation of racial theories of Gobineau and discussion of his fiction; impact of Gobineau’s racist writings and theories, including appropriation by Nazis. Discussion of Darwinism. Comments about translating poetry and working with poet Clayton Eshleman on four books of Césaire’s poetry. Description of Césaire’s life and politics and his importance as a leader and author. Reads her translations of Césaire’s poems. Impressions of foreign language study at Caltech and further descriptions of HSS, including some unfortunate hires and tension in the division. D. Smith’s illness and death. Teaching in Papeete, Tahiti, 1990-1991. Circular nature of her life and work. Purchase of land and building of second home in Point Dume, Malibu, (1980-1981) and celebratory party there. Expressions of gratitude for Caltech and its brilliant scientists and community

    Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.

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    The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatitis B virus infection (CHB). We found Tim-3 to be expressed on a higher percentage of CD4 and CD8 T cells from patients with CHB than healthy controls (p<0.0001) and to be enriched on activated T cells and those infiltrating the HBV-infected liver. Direct ex vivo examination of virus-specific CD8 T cells binding HLA-A2/peptide multimers revealed that Tim-3 was more highly upregulated on HBV-specific CD8 T cells than CMV-specific CD8 T cells or the global CD8 T cell population in patients with CHB (p<0.001) or than on HBV-specific CD8 after resolution of infection. T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. Tim-3 blockade resulted in enhanced expansion of HBV-specific CD8 T cells able to produce cytokines and mediate cytotoxicity in vitro. Blocking PD-1 in combination with Tim-3 enhanced the number of patients from whom functional antiviral responses could be recovered and/or the strength of responses, indicating that these co-inhibitory molecules play a non-redundant role in driving T cell exhaustion in CHB. Patients taking antivirals able to potently suppress HBV viraemia continued to express Tim-3 on their T cells and respond to Tim-3 blockade. In summary, both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver

    Letter from Lt. Col. J. W. Brabner-Smith, Chief, Legal Office, War Department, to Wayne M. Collins, November 6, 1944

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    Letter from J. W. Brabner-Smith to Wayne M. Collins: "Will you kindly send us for our files a copy of your brief in the Korematsu case."The ACLU-Northern California case file records contain legal documents and correspondence pertaining to the case argued before the Supreme Court in Korematsu v. United States (1944), challenging the constitutionality of Executive Order 9066

    Smith, Tim

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    Photograph from the C.R. Savage Portrait Studio. Name associated with the photograph: Tim Smit

    Action prediction across match-on-action cuts in infancy

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    Match-on-action refers to an editing technique where a subject begins an action in one shot and carries it through to completion in the next (Anderson, 1996; Bordwell & Thompson, 2001). The action bridge between shots distracts the viewer from noticing the cut (ie. edit blindness; Smith & Henderson, 2008; Smith & Martin-Portugues Santacreu, 2016) and provides a foundation for the perception of continuity. It is also known that it enables even first-time adult viewers to perceive spatiotemporal continuity between shots who are not able to do so in the absence of continuing action through the cuts (Schwan & Ildirar, 2010; Ildirar& Schwan, 2015). This technique is believed to function by both cuing attentional shifts pre-cut and using motion blur post-cut (Pepperman, 2001) to limit the availability of attention and perceptual discrimination ability of viewers towards the cut (Smith, 2012; Smith & Martin-Portugues Santacreu, 2016). Adults (Flanagan & Johnson, 2003), as well as 12-month-old babies (but not 6-month-olds; Falck-Ytter, Gredebaek & Hofsten, 2006) perform goal-directed, anticipatory eye movements when observing actions performed by others. This anticipatory gaze ability is mediated by a mirror neuron system (MNS; Buccino, 2001; Kohler, 2002) and MNS is only activated when someone is seeing an agent perform actions, not when objects move alone both in adults (Flanagan & Johnson, 2003) and infants (Falck-Ytter et. al.,2008). For anticipating future actions segmenting event into units is critical for both adults and infants. One hypothesis for how event perception progresses is that infants begin with basic, domain-general learning mechanisms that allow them to group actions based on the sequential predictability of the actions they observe (Baldwin & Baird, 2001; Baldwin, Baird, Saylor, & Clark, 2001; Roseberry, Richie, Hirsh-Pasek, Golinkoff, & Shipley, 2011). Infants could use these initial groupings to discover more abstract cues to event structure, such as the actor’s intentions, which are known to play a role in adults’ global event segmentation (e.g., Wilder, 1978; Zacks, 2004; Zacks & Tversky, 2001).Visual sequence learning is a primary mechanism for event segmentation and research show that eight-month-old infants are sensitive to the sequential statistics of actions performed by a human agent (Roseberry et al., 2011). More interestingly, adults (Baldwin, Andersson, Saffran, & Meyer, 2008) as well as infants in their 1st year of life (Stahl, Romberg, Roseberry, Golinkoff & Hirsh‐Pasek, 2014) can segment a continuous action sequence based on sequential predictability alone, which suggest that before infants have top-down knowledge of intentions, they may begin to segment events based on sequential predictability. The study we will present at the conference aims to find out what happens when the observed action is distributed across film cuts. To this purpose we produced two sets of film clips depicting four conditions. In the Single Shot Agent (SSA), an adult sitting in front of a table moved the three objects placed to the one side of the table to the other side shown in one long single shot. In the Multiple Shot Agent (MSA) Condition the action is segmented into taking and putting subactions through multiple film close-ups. In both the Single Shot No Agent (SSNA) and Multiple Shot No Agent (MSNA) conditions the objects move by themselves, one at the time. All film clips end with a long single shot paused when the last object (in agent’s hand or alone) in the middle of its trajectory in order to measure anticipatory saccades by the viewer towards the end point of the object’s trajectory .We defined three areas of interest (AOI): one covering the starting position of the objects (Object AOI), one covering the finishing position of objects (Goal AOI), and one covering the trajectory of the objects (Trajectory AOI). The eye movements of adults (N=20) and 12 month-old infants (N=20) subjects will be measured during each video. The timing of subjects’ saccades from the Object AOI to the Goal AOI will be compared to the arrival of the object. If gaze arrives at the Goal AOI before the object, the trial will be considered predictive. If gaze arrives at the Goal AOI after the object, the trial will be considered reactive. We predict that, based on prior evidence (Falck-Ytter, Gredebaek & Hofsten, 2006), 12 month-old infants and adults will be able to anticipate the end point of a moving object shown in a single long-shot and moved by a human agent but not when the object moves on its own. By comparison, we predict that only adults will anticipate the end point of a an object moved by an agent when it is initially shown via an edited sequence of close-ups. Of critical interest is whether the anticipatory behaviour of infants for the edited sequence is associated with each infant’s daily exposure to moving images (e.g. TV, Film or touchscreen devices) and if such anticipatory behaviour might serve as a future index of visual literacy in pre-verbal children.The results of this study will be discussed with regards to mirror neuron theory of action (Rizzolatti, Fogassiv& Gallese, 2001) and event segmenting theory (Zacks et. al., 2007). This work represents the first steps on understanding how visual literacy emerges in infancy and its parallels with typical cognitive development

    Fabaeformiscandona condylea Smith & Janz 2008, sp. nov.

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    Fabaeformiscandona condylea Smith & Janz, 2008 2008 Fabaeformiscandona condylea sp. nov. —Smith & Janz: 2881–2887, Figs 8 D–F, 11, 12. Material examined. Six males and six females from holes dug into river bars, consisting of cobbles, pebbles, gravel, coarse sand and mud, of the Daido River, near the junction with the Seta River, Shiga Prefecture, N 34 º 56 ’ 03.8”, E 135 º 54 ’ 53.4 ”, 27 September 2009. Material collected by Tom Karanovic and the author. Remarks. Previously this species was reported from beaches of Lake Biwa (Smith & Janz 2008).Published as part of Smith, Robin J., 2011, Groundwater, spring and interstitial Ostracoda (Crustacea) from Shiga Prefecture, Japan, including descriptions of three new species and one new genus, pp. 15-37 in Zootaxa 3140 on page 27, DOI: 10.5281/zenodo.20794
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