2,062 research outputs found
No.136, Vincent E. Clayton, interview by Tim Larson
No full textTranscript (48 pages) of interview by Tim Larson with Vince Clayton, Bonneville International\u27s former vice president of engineering, on June 27, 1986. This interview is no. 136 in the Everett L. Cooley Oral History Project, and tape no. U-474Clayton recalls his long-time employment with KSL radio and television and later Bonneville International where he eventually became vice president of engineering. He discusses his work at KSL, people with whom he associated, the growth of the Bonneville system, and the many technical problems he dealt with, 1940s-1980s. Interviewer: Tim Larso
Sustainability Awareness Week 2021: Climate Anxiety with Dr. Susan Clayton
No full textFive current FIT students and recent graduates will join Daniel Benkendorf and climate anxiety scholar, Dr. Susan Clayton.In this session, Daniel Benkendorf (Psychology) will discuss the issue of climate anxiety with Dr. Susan Clayton, a psychologist who is both an internationally-recognized scholar on this topic and who is also a lead author on the Sixth Assessment Report of the Intergovernmental Panel on Climate Change. A panel of current FIT students and recent graduates will join Benkendorf and Clayton as they define and explore the features and peculiarities of climate anxiety and consider ways to ameliorate it.Sustainability is a key component of FIT’s mission and is embedded in the college’s curriculum and operations. During virtual Sustainability Awareness Week, we invite our community to learn about recent innovations from leaders in the industry, FIT students, faculty, staff, and alumni; experience FIT’s efforts to make a positive impact on the earth; and discover new ways to live with a smaller footprint
Henry De Lamar Clayton, Jr., papers, MSS.0314
No full textAbstract: The majority of this collection contains incoming and outgoing correspondence. It also contains speeches, newspaper clippings, legal documents, personal letters, and a scrapbook related to Henry De Lamar Clayton, Jr's death.Scope and Content Note:Biographical/Historical Note: Son of General H. D. Clayton, Congressman, author of the Clayton Antitrust Act
University jazz bands, February 17, 1999
No full textRecorded during a live performance at Dalton Center Recital Hall, Western Michigan University, Kalamazoo, Michigan, February 17, 1999, 8:00 p.m., the 287th concert of the School of Music's 1998-1999 season.1st-7th works: University Jazz Lab Band, Thomas Knific, director ; 8th-12th works: University Jazz Orchestra, Trent Kynaston, director ; featuring guest artist and composer, John Clayton, Jr., double bass ; with various instrumental soloists.Information from performance program.Ready mix / Bill Holman (Rob Haight, alto saxophone ; Eric Olson, tenor saxophone ; Bartosz Hadala, piano) -- Blackberry winter / Alec Wilder ; arranged by Walt Weiskopf (Chris Knobel, tenor saxophone) -- Mercy mercy mercy / Joe Zawinul ; arranged by Phil Wilson (Chris Knobel, tenor saxophone ; Brett Farkas, guitar) -- Blues for Stephanie / John Clayton, Jr. (Rob Haight, alto saxophone ; Bartosz Hadala, piano ; Adam Bergeron, trumpet) -- Heart & soul / arranged by John Clayton, Jr. -- Two for T / Tom Knific (John Clayton, Jr., Tom Knific, double bass ; Quincy Davis, drums) -- Jazz party / John Clayton, Jr. (Chris Knobel, Eric Olson, tenor saxophone ; Carl Nilsen, drums) -- The humbler / Shawn Wallace (Marc Landes, trumpet ; James Danderfer, tenor saxophone ; Shawn Wallace, alto saxophone ; Quincy Davis, drums) -- Blues for Shatzie / Dave Lambert (Dave Lambert, trombone ; Chris Sargent, piano ; James Danderfer, tenor saxophone) -- Reverence / John Clayton, Jr. (Ryan Bullard, trumpet) -- I be serious 'bout dem blues / John Clayton, Jr. (Tim Priddy, trumpet ; Shawn Wallace, alto saxophone ; Matt Westgate, Raphael Crawford, trombone ; Chris Sargent, piano) -- Soupbone / John Clayton, Jr. (Dave Lambert, trombone ; John Clayton, Jr., double bass)
Claude F. Clayton and others in the new Federal Courtroom.
No full textImage digitized from film negative; Removed from Clayton Collection Miscellaneous Correspondence folderhttps://egrove.olemiss.edu/cfclayton/1127/thumbnail.jp
James (D. Clayton) collection
No full textMSS. 67. 1957-2003 (Bulk Dates: 1964-1996). 23.75 cubic feet. The D. Clayton James papers include the papers of Dr. D. Clayton James (1931-2004) who was a professor of history at Mississippi State University and a prolific author, notably on General Douglas MacArthur. The papers contain correspondence, research files, manuscripts, newspaper clippings, publications and copies of publications, audio and video recordings, microfilm, photographs, and miscellany
Claude F. Clayton seated seated at confirmation hearing with two unidentified men.
No full textJames O. Eastland, Claude F. Clayton, and John C. Stennis; 1931-1938https://egrove.olemiss.edu/cfclayton/1020/thumbnail.jp
Claude F. Clayton with unidentified judge, Judge J.P. Coleman, and Judge John Robert Brown.
No full textJohn Godbold (Ala.), J. P. Coleman, John Brown, and Claude F. Clayton; 1950-1969https://egrove.olemiss.edu/cfclayton/1017/thumbnail.jp
Elucidating Tim-3 Function and Regulation in Human CD8+ T cells
No full textChronic HIV infection results in a loss of HIV-specific CD8+ T cell effector function, termed "exhaustion", which contributes to loss of viral control and progression to AIDS. This exhaustion is driven, in part, by membrane co-inhibitory receptors, including PD-1 and Tim-3, which act to dampen T cell effector function. These receptors are active targets for therapeutic blockade to rescue T cell responses in the context of HIV and cancer. Unlike PD-1, the mechanisms responsible for Tim-3-mediated inhibition of T cell responses are poorly defined, and evidence suggests that Tim-3 can act as a co-stimulatory molecule. My thesis work evaluated the role of Tim-3 at the immunological synapse, confirmed binding to the proximal signaling molecule Lck, and receptor phosphatase CD45 via the Tim-3 ligand, galectin-9. The nature of CD45-mediated regulation of Lck function suggests differential association with CD45 as a possible mechanism to explain Tim-3's opposing functions. Indeed, despite Tim-3 expression on CD45RA+ and CD45RA- T cells, Tim-3 expression on functional T cells was exclusive to the CD45RA- subset. Further, engaging Tim-3 on CD45RA- T cells resulted in co-stimulation. Finally, Tim-3 is shed from the surface of antigen-responsive T cells by matrix metalloproteinase, ADAM10, and shedding is associated with the functional capacity of T cells after TCR engagement. These results suggest that Tim-3 function is dependent on T cell phenotype, and that CD45 isoforms may differentially regulate Tim-3 function via Lck. Further, the fact that functional T cells shed Tim-3 suggests that Tim-3 does not block proximal TCR signaling. I propose that during states of chronic antigenic stimulation Tim-3 may prevent exhaustion by acting as a co-stimulator on activated CD45RA- virus-specific CD8+ T cells, however, during late differentiation, Tim-3 may enhance the negative effects of CD45RA on TCR signaling and contribute to the exhausted phenotype.Ph.D.2018-03-22 00:00:0
Elucidating Tim-3 Function and Regulation in Human CD8+ T cells
No full textChronic HIV infection results in a loss of HIV-specific CD8+ T cell effector function, termed "exhaustion", which contributes to loss of viral control and progression to AIDS. This exhaustion is driven, in part, by membrane co-inhibitory receptors, including PD-1 and Tim-3, which act to dampen T cell effector function. These receptors are active targets for therapeutic blockade to rescue T cell responses in the context of HIV and cancer. Unlike PD-1, the mechanisms responsible for Tim-3-mediated inhibition of T cell responses are poorly defined, and evidence suggests that Tim-3 can act as a co-stimulatory molecule. My thesis work evaluated the role of Tim-3 at the immunological synapse, confirmed binding to the proximal signaling molecule Lck, and receptor phosphatase CD45 via the Tim-3 ligand, galectin-9. The nature of CD45-mediated regulation of Lck function suggests differential association with CD45 as a possible mechanism to explain Tim-3's opposing functions. Indeed, despite Tim-3 expression on CD45RA+ and CD45RA- T cells, Tim-3 expression on functional T cells was exclusive to the CD45RA- subset. Further, engaging Tim-3 on CD45RA- T cells resulted in co-stimulation. Finally, Tim-3 is shed from the surface of antigen-responsive T cells by matrix metalloproteinase, ADAM10, and shedding is associated with the functional capacity of T cells after TCR engagement. These results suggest that Tim-3 function is dependent on T cell phenotype, and that CD45 isoforms may differentially regulate Tim-3 function via Lck. Further, the fact that functional T cells shed Tim-3 suggests that Tim-3 does not block proximal TCR signaling. I propose that during states of chronic antigenic stimulation Tim-3 may prevent exhaustion by acting as a co-stimulator on activated CD45RA- virus-specific CD8+ T cells, however, during late differentiation, Tim-3 may enhance the negative effects of CD45RA on TCR signaling and contribute to the exhausted phenotype.Ph.D.2018-03-22 00:00:0
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