2,091,544 research outputs found
Tim Prebble Profile, NZ On Screen
No full textA profile of sound designer and composer, Tim Prebble, researched and written for NZ On Screen
10xTYPES Vol 2
No full textTypeface archive book featuring ten typefaces design by Tim Hutchinson. Each typeface is displayed as a full specimen throughout the book plus some experimental & live application of selected typefaces at the end f the publication
10XTYPES Vol.3
No full textTypeface archive book featuring ten typefaces design by Tim Hutchinson. Each typeface is displayed as a full specimen throughout the book plus some experimental & live application of selected typefaces at the end of the publication
Dancer from Munyarryun family in 'Laka bunkul' from the 'Dance clan' season at the Bangarra Dance Theatre studios, Pier 4/5, Walsh Bay, Sydney, November 1998 [picture] /
No full textPart of: Tim Webster collection of photographs of Australian dance and dancers.; Title from acquisition documentation and information supplied by photographer.; Acquired in digital format; access copies available online.; Mode of access: Internet via World Wide Web
Yothu Yindi's Wityana Marika and Mangatjay Yunupingu performing at WOMADelaide, Adelaide, 1993 [picture] /
No full textPart of: Tim Webster collection of photographs of Australian dance and dancers.; Title from acquisition documentation.; Acquired in digital format; access copies available online.; Mode of access: Internet via World Wide Web
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
Full text linkThe S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatitis B virus infection (CHB). We found Tim-3 to be expressed on a higher percentage of CD4 and CD8 T cells from patients with CHB than healthy controls (p<0.0001) and to be enriched on activated T cells and those infiltrating the HBV-infected liver. Direct ex vivo examination of virus-specific CD8 T cells binding HLA-A2/peptide multimers revealed that Tim-3 was more highly upregulated on HBV-specific CD8 T cells than CMV-specific CD8 T cells or the global CD8 T cell population in patients with CHB (p<0.001) or than on HBV-specific CD8 after resolution of infection. T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. Tim-3 blockade resulted in enhanced expansion of HBV-specific CD8 T cells able to produce cytokines and mediate cytotoxicity in vitro. Blocking PD-1 in combination with Tim-3 enhanced the number of patients from whom functional antiviral responses could be recovered and/or the strength of responses, indicating that these co-inhibitory molecules play a non-redundant role in driving T cell exhaustion in CHB. Patients taking antivirals able to potently suppress HBV viraemia continued to express Tim-3 on their T cells and respond to Tim-3 blockade. In summary, both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver
Tin Son watch and clock stall at the Queen Victoria Market, Melbourne, 11 November 2002 [picture] /
No full textTitle devised by cataloguer based on information from the photographer.; Part of the collection: Scenes from the Queen Victoria Market, Melbourne, 2002.; Acquired in digital format; access copy available online.; Mode of access: Internet via World Wide Web.; Purchased from the photographer, 2009.; Published in: Market / Tim Webster. Tim Webster Photography, 2009
Two men loading fruits and vegetables into a station wagon from a goods trolley at the top of shed A on Peel Street, Queen Victoria Market, Melbourne, 1 June 2002 [picture] /
No full textTitle devised by cataloguer based on information from the photographer.; Part of the collection: Scenes from the Queen Victoria Market, Melbourne, 2002.; Acquired in digital format; access copy available online.; Mode of access: Internet via World Wide Web.; Purchased from the photographer, 2009.; Published in: Market / Tim Webster. Tim Webster Photography, 2009
Knife sharpening man with a grinder, operating from the back of a minivan in Queen Street, Queen Victoria Market, Melbourne, 23 July 2002 [picture] /
No full textTitle devised by cataloguer based on information from the photographer.; Part of the collection: Scenes from the Queen Victoria Market, Melbourne, 2002.; Acquired in digital format; access copy available online.; Mode of access: Internet via World Wide Web.; Purchased from the photographer, 2009.; Published in: Market / Tim Webster. Tim Webster Photography, 2009
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