488 research outputs found
Correction to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model
No full textCorrection to: Cell Death Dis. (2016) 7, e2359; https://doi.org/10.1038/cddis.2016.263; published online 08 September 2016</jats:p
Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model
No full textGlial cell line-derived neurotrophic factor (GDNF) is a potent survival and regeneration-promoting factor for dopaminergic neurons in cell and animal models of Parkinson disease (PD). GDNF is currently tested in clinical trials on PD patients with so far inconclusive results. The receptor tyrosine kinase Ret is the canonical GDNF receptor, but several alternative GDNF receptors have been proposed, raising the question of which signaling receptor mediates here the beneficial GDNF effects. To address this question we overexpressed GDNF in the striatum of mice deficient for Ret in dopaminergic neurons and subsequently challenged these mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Strikingly, in this established PD mouse model, the absence of Ret completely abolished GDNF’s neuroprotective and regenerative effect on the midbrain dopaminergic system. This establishes Ret signaling as absolutely required for GDNF’s effects to prevent and compensate dopaminergic system degeneration and suggests Ret activation as the primary target of GDNF therapy in PD
Sigmund Freud contra Helga Grebing - Kommentierende Anmerkungen zu den Beiträgen von Max Bloch, Karsten Rudolph, Meik Woyke und Walter Mühlhausen
No full textConcentrating on the contributions of Max Bloch, Karsten Rudolph, Meik Woyke and Walter Mühlhausen the author sums up the contributions of this volume in order to reflect on the current state of research in the field of the historiography of biographies of leading social democrats. He discusses remaining lacunae in research and develops perspectives for future research
B --> ([rho]/[omega]) [gamma] at BaBar
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2007.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.In title on title page, "[right arrow] appears as the symbol; and "[rho]", "[omega]" and "[gamma]" appear as lower-case Greek letters.Includes bibliographical references (leaves 203-205).This document describes the measurements of the branching fractions and isospin violations of the radiative electroweak penguin decays B [right arrow] ([rho]/[omega]) [gamma] at the asymmetric energy e+e- PEP-II collider with the BABAR detector. Together with the previously measured branching fractions of the decays ... the ratio of CKM-matrix elements Vtd=Vts are extracted and the length of the far side of the unitarity triangle is determined.by Karsten Köneke.Ph.D
The Governance of Global Industry Associations:The Role of Micro-Politics
No full textThis insightful book examines the role of micro-politics in the life of global industry associations. Karsten Ronit addresses the various rules and norms required to administer these associations, highlighting the importance of managing variations in complex member demands and responding to expectations in their institutional environment. Posing a variety of empirical and theoretical challenges, the author charts the state of the art in the study of industry associations, evaluating the current condition of research in the field. Ronit offers a systematic approach to the role of global industry associations, identifying, classifying and analysing the diverse population of industry associations and the expressions of micro-politics that occur within them. Addressing key dilemmas such as leadership, resource allocation and regulation, Ronit examines the many policy areas in which industry associations are active and the areas in which their activities overlap with other policy actors. Offering a critical conceptual exploration of the significance of industry associations, this cutting-edge book is crucial reading for scholars and students researching business and politics, particularly those interested in associational governance in global industries. It will also benefit practitioners working in business associations and consulting firms, as well as policymakers addressing industry association
Conductometric titrations in the presence of indifferent electrolytes using bright platinum electrodes
No full textApplied Science
Longitudinal Data Collection in Continental Europe: Experiences from the Survey of Health, Ageing and Retirement in (SHARE)
No full textCorrigendum to “Integration of hydrogeophysical and geological investigations in enhancing groundwater potential assessment in Houtriver gneiss crystalline basement formation of South Africa” (Physics and Chemistry of the Earth (2021) 123, (S1474706521000425), (10.1016/j.pce.2021.103009))
No full textThe name of the 7th author should be: Karsten H. Jensen. With affiliation: Department of Geosciences and Natural Resource Management, University of Copenhagen, Denmark. The name of the 8th author should be: Karen G. Villholth. The acknowledgement should read: The Authors would like to appreciate and thank the sterling work done by the support provided by the Ministry of Foreign Affairs of Denmark via the Danida Fellowship Centre through providing financial support of the project Enhancing Sustainable Groundwater Use in South Africa (ESGUSA), from which this work was part of. Further to this the authors also acknowledge Department of Water and Sanitation (Polokwane)‘s resource assessment team for equipment and manpower assistance provided during field work. The authors would like to apologise for any inconvenience caused.</p
Coating layer on samples with roughness: numerical study for coherent Fourier scatterometry
No full textFor the development of integrated circuits, the accompanying metrology inside the fabrication process is essential. Non-imaging metrology of nanostructure has to be quick and non-destructive. The multilayers are crucial components of today's microprocessor nanostructures and reflective coatings. Coherent Fourier scatterometry (CFS), which is currently employed as a method for determining certain parameters of nanostructures and isolated particle detection, has not been investigated in the context of multilayer characterization. Retrieving the thickness of many wavelength-thick films using a coherent visible-range source at a full-complex-field measurement is the specific application where CFS might be advantageous. Furthermore, due to polishing in the realistic multilayers, the anticipated optical performance suffers from stochastic changes relating to surface roughness. Few non-imaging metrology methods take into consideration these statistic variances and thus are of interest for this study. Operating in the visible regime, CFS can become a viable candidate to provide cover layer reconstruction in the presence of surface roughness that has a correlation length bigger than the characteristic spot size i.e., in the range of microns. We present forward model results of multilayer structure as measured with visible range CFS modality. The influence of surface roughness is taken into account and the simulation results are discussed. Simulations of micron-sized layers of dielectric on silicon substrate suggest an influence on the far field intensity that motivates a future extended study on experimental multiple wavelength thick cover layer reconstruction in the presence of roughness. ImPhys/Pereira grou
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