181,897 research outputs found
Is UNESCO Recognition Effective in Fostering Tourism? A Comment on Yang, Lin and Han: Reply
No full textCome tradurre Milo De Angelis
No full textThe section presents the Chinese translation of four poems by Milo De Angelis, who is
among the best Italian contemporary poets. The poems are taken from the collection "Incontri e agguati" (Mondadori, 201 5). The texts are both in Italian and Chinese in parallel
text. Yang Lin, with the help of Geng Jiang (Chinese musician and poet), took care of the
translation.
The section opens with a note made by the translation group that analyses the processes
of the transposition of the dense poetic language of De Angelis into the Chinese language.
There follows an enlightening letter from Milo De Angelis to the translation group. The four
poems in Chinese and Italian complete the section
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
Eutetrapha weni Huang & Lin 2016
No full textEutetrapha weni Huang & Lin, 2016 Figs. 63–65 Eutetrapha weni Huang & Lin, 2016: 590, figs. 1–23. Diagnosis. This species can be separated from congeners by the unique brick red brown pubescence and unique elytral markings, larger body size, and unique golden brown metatarsi. Remarks. For descriptions, see paper by Huang & Lin (2016). The description of male genitalia was in older style (Huang & Lin 2 016) and some terminology terms are changed in this work: median lobe plus median struts = median lobe; internal sac = endophallus; basal armature = basal plate-like sclerites; rods of endophallus = rod-like sclerites. Distribution. China: Guizhou. Material examined. Holotype, male (Fig. 62, and Figs. 1 a & 1b in Huang & Lin 2016), China, Guizhou, Leishan, Mt. Leigongshan, Lianhuaping, N26°22′, E108°12′, alt. 1631 m, 2014. VI.18, leg. Jing Yang (IZAS, IOZ (E) 1905306, ex KLUC). Paratypes: 1 female, same data to holotype but deposited in (KLUC); 1 female, same data to holotype but 2014. VI.16 and deposited in (KLUC); 1 male (Fig. 13 in Huang & Lin 2016) 1 female (Figs. 8 a, 8b & 14 in Huang & Lin 2016), same data to holotype but 2014. VI.21, leg. Yang Li (IZAS, IOZ (E) 1905304–05, ex KLUC); 1 female (Fig. 65), same data to holotype but, 2011. VIII.11, leg. Jian-Yue Qiu & Hao Xu (CWD); 1 female, same data to holotype, but 2015. VII.12, leg. Bo-Yan Li (CGQH); 1 male (Fig. 64), S. China, SE. Guizhou, Dushan County, Gengdingshan env., N25°52.5′, E107°38′, alt. 1445 m, 2009.VI, leg. Sehnal et Hackel (CPV).Published as part of Lin, Mei-Ying, Bi, Wen-Xuan & Yang, Xing-Ke, 2017, A revision of the genus Eutetrapha Bates (Coleoptera: Cerambycidae: Lamiinae: Saperdini), pp. 151-202 in Zootaxa 4238 (2) on pages 172-173, DOI: 10.11646/zootaxa.4238.2.1, http://zenodo.org/record/34519
Parastenostola nigroantennata Lin et Yang, sp. nov.
No full textParastenostola nigroantennata Lin et Yang, sp. nov. (Figs. 24–29) Description. Male: length: 14.0– 14.5 mm, humeral width: 4.0– 4.3 mm. Female: length: 14.0– 17.8 mm, humeral width: 4.0– 5.2 mm. Body black; frons densely closed with yellow pubescence, eyes circled with yellow pubescence, occiput black; antennae pitchy with thick gray pubescence; pronotum with a moderate black macula not reaching basal margin on disc, with yellow pubescence at sides except for a small black spot on middle of each side; scutellum and elytra black with dense gray short pubescence, giving a black-gray appearance; ventral surface clothed with yellow pubescence at sides and with gray pubescence along middle of venter; pubescence on mesepisternum not so thick, gray, sometimes mixed with yellow. Head fine and unevenly punctured. Lower eyelobes much longer (male) or slightly longer (male) than genae. Antennae not stout, longer (male) or slightly shorter (female) than body length; antennomere ratio: male: 16 4 25 21 16 15 14 13 12 11 13; female: 14 3 21 19 16 12 11 10 9 9 10. Punctures on pronotum irregular and uneven. Scutellum linguaform. Elytra evenly narrowed posteriorly, rounded or slightly truncated apically, densely punctured, punctures smaller than their interspaces. Legs moderately stout, middle tibiae with lots of hairs externally, hind femur reaching middle to apex of third abdominal segment. Male genitalia (Fig. 27): Tegmen about 3.4 mm; lateral lobes short, each about 0.5 mm long and 0.12 mm wide, with setae at the apex and around of dorsal surface, with two small lobes furnished with short and fine hairs at the ventral base; roof very short; ringed part elbowed in the widest portion, converging; basal piece slightly bifurcated distally; median lobe with median struts slightly curved, a little longer than tegmen (20: 17); the former distinctly shorter than the latter, less than 1 / 2 of median struts; dorsal plate subequal to ventral plate; the ventral edge of median orifice weakly projected; median foramen extremely elongated; internal sac moderately long, with four long and thin rods and a small crescent armature at the basal of rods, the hair-like rods about 5.0 mm, much longer than tegmen or median lobes. Ejaculatory duct single. Female genitalia (Figs. 28–29): Setae of sternite 7–8 long, extending beyond apex. Spermatheca distinctly curved, dividing into 5–8 different parts, about 2.2 mm long for a 17 mm adult. Tignum short, shorter than 1 / 3 of abdomen. The tignum 1.9 mm for an adult with a 7.0 mm abdomen in ventral view. Diagnosis. Differs from P. brunnips (Gahan) in the black antennae, femera and tibiae. Etymology. This species differs from P. brunnips (Gahan) by the black antennae. Type specimens examined. Holotype: male, Guangxi, Tianlin county, Langping Xiang, 1200–1400 m, 2002. V. 29, coll. Jianwen Liu (IZAS). Paratypes: 1 male, Guangxi, Tianlin county, Jiudongping, 1200–1300 m, 2002. V. 27, coll. Xiujuan Yang (HBU); 1 female, Guangxi, Tianlin county, Yaojiawan, 1200–1400 m, 2002. VI. 3, coll. Xiujuan Yang (HBU); 1 male 1 female, Guangxi, Wuming county, 2005. VI. 20–30, coll. Chenghui Zhan (IZAS); 1 female, Guangxi, NNW 100 k of Nanning, Mt. Damingshan, 2005.VI (CWIC); 1 female, Guizhou, Guiyang Forest Park, 2007. V. 9, leg. Meng Yuan & Long Zhang (IZAS). Distribution. China: Guangxi, Guizhou.Published as part of Lin, Meiying, Li, Wenzhu & Yang, Xingke, 2008, Taxonomic review of three saperdine genera, Mandibularia Pic, Mimocagosima Breuning and Parastenostola Breuning (Coleoptera: Cerambycidae: Lamiinae: Saperdini), pp. 1-17 in Zootaxa 1773 on pages 12-13, DOI: 10.5281/zenodo.27427
A review on optical actuators for microfluidic systems
No full textDuring the last few decades microfluidic systems have become more and more popular and their relevance in different fields is continually growing. In fact, the use of microchannels allows a significant reduction of the required sample-volume and opens the way to a completely new set of possible investigations, including the study of the properties of cells, the development of new cells’ separation techniques and the analysis of single-cell proteins. One of the main differences between microscopic and macroscopic systems is obviously dictated by the need for suitable actuation mechanisms, which should allow precise control of microscopic fluid volumes and of micro-samples inside the fluid. Even if both syringe-pump and pneumaticpump technologies significantly evolved and they currently enable sub-μL samples control, completely new approaches were recently developed for the manipulation of samples inside the microchannel. This review is dedicated to describing different kinds of optical actuators that can be applied in microfluidic systems for sample manipulation as well as for pumping. The basic principles underlying the optical actuation mechanisms will be described first, and then several experimental demonstrations will be reviewed and compared
A Comprehensive Review of Optical Stretcher for Cell Mechanical Characterization at Single-Cell Level
No full textThis paper presents a comprehensive review of the development of the optical stretcher, a powerful optofluidic device for single cell mechanical study by using optical force induced cell stretching. The different techniques and the different materials for the fabrication of the optical stretcher are first summarized. A short description of the optical-stretching mechanism is then given, highlighting the optical force calculation and the cell optical deformability characterization. Subsequently, the implementations of the optical stretcher in various cell-mechanics studies are shown on different types of cells. Afterwards, two new advancements on optical stretcher applications are also introduced: the active cell sorting based on cell mechanical characterization and the temperature effect on cell stretching measurement from laser-induced heating. Two examples of new functionalities developed with the optical stretcher are also included. Finally, the current major limitation and the future development possibilities are discussed
Acoustofluidic separation: impact of microfluidic system design and of sample properties
No full textWe describe the results of a numerical study about the separation of fluid-suspended microsamples (as microbeads and cells) by acoustophoresis. A microfluidic channel with rectangular cross section is considered, and we investigate the impact on particle separation of many different parameters, dividing them in two groups: sample’s intrinsic factors (own properties of the sample) and extrinsic factors (related to the microfluidic system design and operation). Differently from what is usually done, we include in our study the impact of the initial sample position, which always has a certain variability in real experiments, and we introduce several new parameters allowing to assess system performance and to optimize the microchip separation efficiency. The obtained results show the importance of two design parameters that are generally overlooked: the channel width and the offset between the channel border and the input of the target samples in the microchannel. Additionally, the analysis method we describe and the new parameters we introduce to study the system can be beneficially used in almost any study of acoustophoretic-based separation system
Separation efficiency maximization in acoustofluidic systems: study of the sample launch-position
No full textThe development of lab-on-chip microfluidic systems based on acoustic actuation, and in particular on the acoustophoretic force, has recently attracted significant attention from the scientific community thanks, in part, to the possibility of sample sorting on the basis of both geometrical and mechanical properties. It is commonly recognized that sample prefocusing and launch-position optimization have a substantial effect on the performance of these systems but a clear explanation of how these two parameters influence the system efficiency is still missing. In this manuscript we discuss the impact of both the sample launch position and the sample distribution at the input by the theoretical analysis of a simplified system and by numerical simulations of realistic configurations. The results show that the system performance can be greatly improved by selecting the proper microchannel dimensions and sample-launch position, offering relevant guidelines for the design of micro-acoustofluidic lab-on-chip devices
[[alternative]]Tien Pei-Lin' Educational Thought and Academic Career
No full text[[abstract]]ABSTRACT
Tien Pei-Lin was born in 1893, and dead in 1975. Tien Pei-Lin had devoted himself to the education in Honan in his early lifehood. In addition, he had also devoted himself to the education in Taiwan since he came to Taiwan in 1938. He is an educational thinker and practitioner.
This study is the first thesis on exploring Tien Pei-Lin’
educational thought and academic career in our country. As far as the research method is concerned, the study is to make use of documentary analysis method and interview method. As to the content of study, at first, it illustrates Tien Pei-Lin’life and important works to illuminate his life process and central ideal. Secondly, the study inquires Tien Pei-Lin’ historical background and influence of other scholars to make us understand his philosophical basis and philosophical views. Thirdly, the study aims at inquiring Tien Pei-Lin’ educational thought and academic career to make us realize his educational thought and his contributions to our country’s education and culture. At last, the study illustrates Tien Pei-Lin’ educational thought implications, and thus it makes some suggestions for contemporary education.
一、Implications
1.Education is a process of creating spiritual values.
2.We need to criticize the deficiency of quantitative research paradigm.
3.We need to reflect educational love in the relationship between teachers and students.
二、Suggestions
1.Education should emphasize the creation of spiritual values.
2.The teacher should advocate educational love.
3.We need to develop the views of teacher education which adapts to social changes.
4.We need to develop the educational institution which is based on traditional culture.
5.We need to develop the research paradigm which involves qualitative research and quantitative research.
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