170,390 research outputs found
Per un catalogo dei disegni di Pellegrino Tibaldi: una segnalazione
No full textIl contributo segnala e discute un disegno inedito attribuibile alla maturità di Pellegrino Tibaldi
A Survey of FPGA Optimization Methods for Data Center Energy Efficiency
No full textThis article provides a survey of academic literature about field programmable gate array (FPGA) and their utilization for energy efficiency acceleration in data centers. The goal is to critically present the existing FPGAs energy optimization techniques and discuss how they can be applied to such systems. To do so, the article explores current energy trends and their projection to the future with particular attention to the requirements set out by the European Code of Conduct for Data Center Energy Efficiency. The article then proposes a complete analysis of over ten years of research in energy optimization techniques, classifying them by purpose, method of application, and impacts on the sources of consumption. Finally, we conclude with the challenges and possible innovations we expect for this sector
Is erlotinib really active after failure of gefitinib in advanced non-small-cell lung cancer patients?
No full text
Dynamically-Tunable Dataflow Architectures Based on Markov Queuing Models
No full textDataflow architectures are fundamental to achieve high performance in data-intensive applications. They must be optimized to elaborate input data arriving at an expected rate, which is not always constant. While worst-case designs can significantly increase hardware resources, more optimistic solutions fail to sustain execution phases with high throughput, leading to system congestion or even computational errors. We present an architecture to monitor and control dataflow architectures that leverage approximate variants to trade off accuracy and latency of the computational processes. Our microarchitecture features online prediction based on queuing models to estimate the response time of the system and select the proper variant to meet the target throughput, enabling the creation of dynamically-tunable systems
Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin
No full textAbstract not availableMarcello Tiseo, Elisa Giovannetti, Carmelo Tibaldi, Andrea Camerini, Francesco Di Costanzo, Fausto Barbieri, Jacobus A. Burgers, Andrew Vincent, Godefridus J. Peters, Egbert F. Smit, Andrea Ardizzon
Partial substitution of fish meal with vegetable protein sources in a diet for sea bass: effects on lipogenesis
No full textThe quality of farmed fish products is influenced by adiposity. The aim of this work is to
evaluate the effects of vegetable proteins in practical diets for sea bass on adiposity and
lipid metabolism, and the lipid composition of muscle in juvenile sea bass (Dicentrarchus
labrax)
Proteine vegetali quali sostituti parziali della proteina da farina di pesce in diete per la spigola: effetti sulla lipogenesi
No full textA note on the use of plasma urea level to validate the arginine requirement assessed by growth data in sea bass (D. labrax)
No full textResponsiveness of urea synthesis to dietary arginine is believed to be predictable in the European Sea Bass (D. labrax) because of the high level of arginase activity in this species (Corti et al., 1985). In rainbow trout fry, Cho et al., (1992) have used post-prandial serum urea level to confirm the arginine requirement assessed by growth parameters. A similar approach was applied in the present study to fingerling sea bass by measuring plasma urea levels.
The experiment started at the end of a seven week trial carried out to assess the arginine requirement of fingerling sea bass (Tibaldi et al., unp. res.). Fish (12–18 g) were kept in 65 1 flow-through tanks (temperature 25°C and salinity 15 ‰) and fed seven isonitrogenous (47% N × 6.25) isolipidic (12% EE) diets containing graded levels of Arginine (L-ARG). A basal diet (diet 1) was formulated to be limiting in arginine (1% by weight). It contained maize gluten (300 g/kg), fish meal (100 g/kg) and mixtures of essential and dispensable AA to simulate the AA composition of sea bass muscle protein. Diets from 2 to 7 were obtained by adding 3, 6, 9, 12, 15 and 18 g/kg of crystalline L-ARG to the basal diet. Diet 4 was used in a preliminary study in order to determine the time pattern of post-prandial changes in plasma urea levels. Fish were withdrawn for blood sampling 1,3,5,7,9,12 and 24 hr after the morning meal. Peak urea level was found 5 hr post-prandial so that all the blood samples were taken 5 hr after the single meal. Blood was collected by severing the caudal peduncle and plasma was stored under liquid N and analysed for urea content within 24 hr. Three fish were sampled for each time period (preliminary study) and per diet.
The arginine requirement of fingerling sea bass estimated by the dose-growth relationship was found to be 4% of the dietary protein. The 5 hr post-prandial plasma urea level varying with the arginine content of the diet and increased from 0.40 ± 0.04 mM (diet 1, ARG content 2.2% of the protein) to 0.61 ± 0.08 mM (diet 2, ARG 2.9%) without any further change up to diet 4 (ARG 4.2%, plasma urea 0.63 ± 0.04 mM). A sharp increase was noted thereafter (± 180%) by elevating the dietary arginine up to 5.4 % of the protein (diet 6, plasma urea 1.11 ± 0.03 mM). The critical dietary arginine value of 4.2% based on plasma urea level was similar to the dietary requirement estimated by growth rate (4%)
Stability of a collapsing volcano (Stromboli, Italy) : Limit equilibrium analysis and numerical modelling
No full textStromboli is an active island volcano, belonging to the Aeolian Archipelago (Italy). In the last 13 ka it experienced four lateral collapses affecting its northwestern flank, with its most recent volcanic crisis (December 2002) associated with landslides and related tsunami events. This paper presents the first stability analysis of the Stromboli volcanic edifice. The main input is the geotechnical model of the volcano, defined on the basis of stratigraphical, lithological, material properties, and structural data, collected from in-situ surveys and laboratory tests. Two-dimensional stability analysis was performed by limit equilibrium methods (LEM) and finite difference modelling (FLAC 4.0 code), mainly focusing on the subaerial part of Stromboli's NW flank (Sciara del Fuoco). The variability of the Safety Factor was studied by deterministic, sensitivity and probabilistic analysis focusing on the effect of external forces, such as magma pressure and seismicity, as potential triggering mechanisms of lateral collapse. The LEM analyses were developed considering a maximum depth of 150-350 in for the sliding surface, to which correspond collapse volumes of 95,000-185,000 m(3)/m, respectively. The study shows that, without external forces, the investigated rock mass is stable and that the tectonic seismicity of the area alone does not destabilize the studied slope. On the contrary, magma pressure in dykes can represent a destabilizing factor. Numerical modelling results are concordant with those from LEM. In addition, the simulation reveals that deformations and superficial landslides, preannounce and contribute to retrogressive plasticization and maybe to failure surface deepening. Shallow submarine landslides represent a possible triggering mechanism, and the landslide events of 30 December 2002 consistently fit the simulated evolution. FLAC has revealed to be a useful tool for modelling such a complex system, it allowed to calibrate the response of the geotechnical model, test the validity of the assumptions, simulate the stress-strain evolution, and prepare a possible model for future scenarios. (c) 2004 Elsevier B.V. All rights reserved
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