170,460 research outputs found
Lester C. Thurow. — Dangerous Currents — The State of Economies
No full textRivière Jean. Lester C. Thurow. — Dangerous Currents — The State of Economies. In: Revue Française d'Etudes Américaines, N°19, février 1984. Hollywood au miroir. pp. 155-156
Building wealth the new rules for individuals, companies, and nations in a knowledge-based economy
No full text"As we stand on the brink of the new millennium, MIT economist Lester Thurow addresses the critical issue of wealth creation. The result is an essential road map for how individuals, companies, and nations can and must build wealth in a knowledge-based global economy." "In the final chapters, Professor Thurow turns his attention to the three current major economic sectors of the world: America, East Asia, and Europe. He provides a trenchant analysis of each as a significant competitor in the coming decades, and predicts the likely outcome of the complex forces that are presently shaping global society."--BOOK JACKET
Medicine versus Economics
No full textThurow maintains that current health care cost containment efforts
will lead to an unequal three-tiered system of care financed by prospective
payments from government for basic care of indigents, by payments from
employers for more care for the majority, and by a free market limited only by
what individuals are willing to pay. He proposes an alternative method of
cost containment in which a physician's practice would be based on employing a
treatment only when there is a strong probability of its improving a patient's
condition and eschewing new procedures until they have been demonstrated to
work well. (KIE abstract
Tobacco bZIP factor TGA10 is a novel member of the TGA family of transcription factors
No full textTGA factors constitute a family of conserved plant bZIP transcription factors that regulate transcription from as-1-like elements in response to plant signalling molecules salicylic acid ( SA), methyl jasmonate (MJ) and auxin. Based on sequence similarities, two subclasses of TGA factors have been identified before in tobacco: class I factors (TGA1a and PG13) are preferentially expressed in root tip meristems, whereas class II factors ( TGA2.1 and TGA2.2) are found in leaves and in roots. Here we describe a novel member of the tobacco TGA family (TGA10), which defines a distinct subclass of its own. TGA10 mRNA and TGA10 protein were found in roots but not in leaves of mature tobacco plants. TGA10 binds specifically to the as-1 element, interacts with TGA2.2, and activates transcription in yeast. When ectopically expressed in leaves, TGA10 enhanced SA-, auxin- and MJ-inducibility of target gene Nt103, which responds in the same manner to enhanced levels of TGA2.2. This indicates that TGA10, albeit normally not present in leaves, can interact with the leaf regulatory network controlling transcription from as-1-containing promoters. However, Nt103 expression was not affected in roots of TGA10-over-expressing plants, implying the existence of root-specific mechanisms which do not allow a positive effect of increased TGA10 levels on target gene expression
THUROW, Lester. The Zero-Sum Society. Distribution and Possiblities for Economic Change
No full textTHUROW, Lester. The Zero-Sum Society. Distribution and Possiblities for Economic Chang
Tobacco TGA factors differ with respect to interaction with NPR1, activation potential and DNA-binding properties
No full textIn higher plants, as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Originally found in viral and T-DNA promoters, they are also functional elements of plant promoters activated during the defence response against pathogens. Tobacco bZIP transcription factor TGA1a was the first recombinant protein shown to bind to as-1. cDNAs for two novel tobacco as-1-binding bZIP proteins (TGA2.1 and TGA2.2) were isolated. Revealing a high degree of amino acid identity in the bZIP domain (89%) and the C-terminus (79%), the two TGA2 factors differ remarkably with respect to the length of the N-terminus (170 amino acids in TGA2.1 versus 43 amino acids in TGA2.2). TGA2.1 and TGA2.2, but not TGA1a, interacted with ankyrin repeat protein NPR1, a central activator of the plant defence response. In contrast, TGA2.1 and TGA1a, but not TGA2.2, functioned as transcriptional activators in yeast. Apart from conferring transcriptional activation, the N-terminal domain of TGA2.1 led to reduced in vitro as-1-binding activity and almost completely abolished binding to one half site of this bifunctional element. When being part of a heterodimer with TGA2.2, TGA2.1 was efficiently recruited to a single half site, though double occupancy of the element was still preferred. In contrast, TGA1a preferred to bind to only one palindrome, a feature that was also maintained in heterodimers between TGA1a and TGA2.1 or TGA2.2
Tobacco transcription factor TGA2.2 is the main component of as-1-binding factor ASF-1 and is involved in salicylic acid- and auxin-inducible expression of as-1-containing target promoters
No full textIn higher plants, activating sequence-1 (as-1) of the cauliflower mosaic virus 35 S promoter mediates both salicylic acid (SA)- and auxin-inducible transcriptional activation. Originally found in promoters of several viral and bacterial plant pathogens, as-1-like elements are also functional elements of plant promoters activated in the course of a defense response upon pathogen attack. Nuclear as-1-binding factor (ASF-1) and cellular salicylic acid response protein (SARP) bind specifically to as-1. Four different tobacco bZIP transcription factors (TGA1a, PG13, TGA2.1, and TGA2.2) are potential components of either ASF-1 or SARP. Here we show that ASF-1 and SARP are very similar in their composition. TGA2.2 is a major component of either complex, as shown by supershift analysis and Western blot analysis of DNA affinity-purified SARP. Minor amounts of a protein immunologically related to TGA2.1 were detected, whereas TGA1a was not detectable. Overexpression of either TGA2.2 or a dominant negative TGA2.2 mutant affected both SA and auxin (2,4D) inducibility of various target promoters encoding as-1-like elements, albeit to different extents. This indicates that TGA2.2 is a component of the enhancosome assembling on these target promoters, both under elevated SA and 2,4D concentrations. However, the effect of altered TGA2.2 levels on gene expression was more pronounced upon SA treatment than upon 2,4D treatment
Debate - IAEE 1986 Annual Conference: Debate Between T. Boone Pickens and Lester C. Thurow
No full textMr. Pickens is a leader in the recent restructuring of the oil industry, while Professor Thurow is a prominent analyst of its implications. This debate (with the question-and-answer session omitted for reasons of space) is presented because of the importance of the issues discussed, the caliber of the speakers, and the colorful and lively exchange of ideas.
Generating inequality: mechanisms of distribution in the U.S. economy/ thurow
No full textxiv, 258 hal.: tab.; 21 cm
Generating inequality: mechanisms of distribution in the U.S. economy/ Thurow
No full textxiv, 258 hal.: tab.; 21 cm
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