363 research outputs found
VISION Invited lecture - Microfluidic technologies and their applications in cell biology
No full textRecording and presentation of the invited lecture that took place online on 27 April 2021 - Thorsten Knoll - Microfluidic technologies and their applications in cell biology.
In the past twenty years, microfluidic devices and systems have gained in importance in the field of bioanalytics and biomedicine, not only in research but also in the market. Lab-on-chip systems with microfluidic structures serve for medical tests with body fluids or extractions from fluids. Besides, microfluidic systems are also used for cell handling and culturing, for the mixing of liquids and for measuring quantitative amounts of components in liquid samples.
Fraunhofer IBMT develops microfluidic systems for various applications in the field of life sciences. Different miniaturized approaches and solutions exist e.g. for transport studies or toxicological assays with single cells, 2D cell layers or 3D cell aggregates.
The online lecture will cover some basic considerations regarding microfluidics and IBMT’s technological solutions for the fabrication of microfluidic devices and their use in different application scenarios. Furthermore, the presentation describes solutions for the integration of the microfluidic devices in a complete set-up comprising of peripheral fluidic components and optical or electrical measurement systems
A look at the scholarship of Harvard's famous Professor Andrew H. Knoll (comparing DASH and Google Scholar)
No full textAndrew H. Knoll is * Fisher Professor of Natural History and * Professor of Earth and Planetary Sciences * Curator of the Paleobotanical Collections in the Harvard University Herbaria http://www.oeb.harvard.edu/faculty/knoll/knoll-oeb.html http://www.eps.harvard.edu/people/faculty/knoll http://en.wikipedia.org/wiki/Andrew_H._Knoll Browsing by Harvard-affiliated Author "Andrew Herbert Knoll" in "DASH" (Digital Disappointing Access to Scholarship at Harvard, see http://archiv.twoday.net/stories..
A look at the scholarship of Harvard's famous Professor Andrew H. Knoll (comparing DASH and Google Scholar)
No full textAndrew H. Knoll is * Fisher Professor of Natural History and * Professor of Earth and Planetary Sciences * Curator of the Paleobotanical Collections in the Harvard University Herbaria http://www.oeb.harvard.edu/faculty/knoll/knoll-oeb.html http://www.eps.harvard.edu/people/faculty/knoll http://en.wikipedia.org/wiki/Andrew_H._Knoll Browsing by Harvard-affiliated Author "Andrew Herbert Knoll" in "DASH" (Digital Disappointing Access to Scholarship at Harvard, see http://archiv.twoday.net/stories..
Harvard's Disappointing DASH: Short Update on the Knoll Case
No full text?p=20051 There are now 123 articles by Professor Knoll. None of the 23 newest articles (at the time of my test there were 100 Knoll articles in DASH) is Open Access in DASH - all are only providing links to the published version: "At the direction of the depositing author this work is not currently accessible through DASH." There is now an field "Other sources" with links to eventually free online versions. But these links are not complete, see e.g. http://dash.harvard.edu/handle/1/3190372 W..
Domestic Imprints: Florence Knoll and the role of domesticity in the early post-war american office
No full textThe early 20th century office was strongly affected by the Taylor’s ideas on people’s productivity. Office workers were closely treated like machine parts conducting specific activities of the “production line”. The architectural space was designed as to increase the workers’ productivity and it was molded by the new subjectivity (Neue Sachlichkeit). However, by the end of the second world war emerged a foreground for more humanized environments. Architects, such as Florence Knoll, played a predominant role on the humanization of the corporate environment and the democratization of space. The subject of this thesis is to investigate the role that domesticity played towards the humanization of the corporate environment through the work of Florence Knoll Bassett. Departing from her drawing of the conference room, the thesis pursues to reveal the aspirations derived from the domestic narrative in the design of corporate spaces during the early post-war period in the United States.AR2A011Architecture, Urbanism and Building Science
"Notes on the Ukrainian question” from December 1917 by Roman Knoll
No full textW artykule prezentowany jest mało znany memoriał z grudnia 1917 r., sporządzony przez czołowego działacza Polskiej Centrali Demokratycznej na Rusi, późniejszego wybitnego dyplomatę, Romana Knolla. Autor przedstawił w nim syntetyczną ocenę wydarzeń rewolucyjnych nad Dnieprem i zarysował program działań odradzającego się państwa polskiego wobec Ukrainy. Myśli zawarte w tym dokumencie, rozwijane przez Knolla w następnym okresie, wywarły istotny wpływ na formułowanie się założeń polityki wschodniej obozu piłsudczykowskiego.Th e article presents a little-known memorial drawn up in December 1917 by a leading activist of the Polish Democratic Centre in Ruthenia and, later on, a prominent diplomat Roman Knoll. In the memorial, the author presented a synthetic assessment of the revolutionary events on the Dnieper and outlined a programme of action for the reborn Polish state with regard to Ukraine. Th e thoughts contained in this document, which Knoll developed in the following period, signifi cantly infl uenced the formulation of the Piłsudski camp’s eastern policy
“Notes on the Ukrainian Question” from December 1917 by Roman Knoll
No full textW artykule prezentowany jest mało znany memoriał z grudnia 1917 r., sporządzony przez czołowego działacza Polskiej Centrali Demokratycznej na Rusi, późniejszego wybitnego dyplomatę, Romana Knolla. Autor przedstawił w nim syntetyczną ocenę wydarzeń rewolucyjnych nad Dnieprem i zarysował program działań odradzającego się państwa polskiego wobec Ukrainy. Myśli zawarte w tym dokumencie, rozwijane przez Knolla w następnym okresie, wywarły istotny wpływ na formułowanie się założeń polityki wschodniej obozu piłsudczykowskiego.The article presents a little-known memorial drawn up in December 1917 by a leading activist of the Polish Democratic Centre in Ruthenia and, later on, a prominent diplomat Roman Knoll. In the memorial, the author presented a synthetic assessment of the revolutionary events on the Dnieper and outlined a programme of action for the reborn Polish state with regard to Ukraine. The thoughts contained in this document, which Knoll developed in the following period, significantly influenced the formulation of the Piłsudski camp’s eastern policy
New perspectives on distributive justice: deep disagreements, pluralism, and the problem of consensus/ edited by Manuel Knoll, Stephen Snyder, Nurdane Şimşek.
No full textIn English.Includes bibliographical references and indexes.Distributive justice is one of the most discussed topics in political philosophy. Focusing on the plurality of irreconcilable conceptions of social and political justice, this book presents an array of new perspectives on the topic. Bringing together more than 20 original essays of well-established and young international scholars, the volume is essential reading for anyone interested in social and political justice.Knoll, Manuel / Snyder, Stephen / Şimşek, Nurdane -- Knoll, Manuel -- Steinvorth, Ulrich -- Haus, Michael -- Giorgini, Giovanni -- Wolthuis, Bertjan -- Knoll, Manuel / Şimşek, Nurdane -- Lisi, Francisco L. -- Schütrumpf, Eckart -- Horn, Christoph -- Kukathas, Chandran -- Siani, Alberto L. -- Lim, Chong-Ming -- Spohn, Ulrike -- Westphal, Manon -- Rupniewski, Michał -- Caven, Peter -- Kallhoff, Angela -- Förster, Annette -- Wringe, Bill -- Snyder, Stephen -- Tan, Kok-Chor -- Schoelandt, Chad Van / Gaus, Gerald -- Irrera, Elena -- Dimitrova, Maria -- Bailey, Tom -- Koller, Peter -- Demir, Aysel -- Young, Jeffrey -- Stocker, Barry -- Frontmatter -- Table of Contents -- List of Abbreviations -- Introduction: Two Opposing Conceptions of Distributive Justice / Part I: Deep Disagreements -- Deep Disagreements on Social and Political Justice: Their Meta-Ethical Relevance and the Need for a New Research Perspective / Are There Irreconcilable Conceptions of Justice? Critical Remarks on Isaiah Berlin / Equality beyond Liberal Egalitarianism: Walzer’s Contribution to the Theory of Justice / Stuart Hampshire and the Case for Procedural Justice / Public Reason in Circumstances of Pluralism / Does Rawls’s First Principle of Justice Allow for Consensus? A Note / Part II: Ancient Perspectives and Critiques of the Centrality of Justice -- Aristotle on Natural Right / What Is “Just in Distribution” in Aristotle’s Nicomachean Ethics and Politics – Too Much Justice, Too Little Right / Justice in Ethics and Political Philosophy: A Fundamental Critique / Justicitis / Part III: The Problem of Consensus -- Rawls on Overlapping Disagreement and the Problem of Reconciliation / Public Reason, Compromise within Consensus, and Legitimacy / From Consensus to Modus Vivendi? Pluralistic Approaches to the Challenge of Moral Diversity and Conflict / What Bonds Citizens in a Pluralistic Democracy? Probing Mouffe’s Notion of a Conflictual Consensus / Citizenship, Community, and the Rule of Law: With or Without Consensus? / Political Liberalism: The Burdens of Judgement and Moral Psychology / Part IV: Expanding the Perspective on Obligations -- John Rawls and Claims of Climate Justice: Tensions and Prospects / Assistance, Emergency Relief and the Duty Not to Harm – Rawls’ and Cosmopolitan Approaches to Distributive Justice Combined / Global Collective Obligations, Just International Institutions and Pluralism / Intergenerational Justice in the Age of Genetic Manipulation / Part V: Diversifying the Perspective -- The Contours of Toleration: A Relational Account / Constructing Public Distributive Justice: On the Method of Functionalist Moral Theory / Respect as an Object of Equal Distribution? Opacity, Individual Recognition and Second-Personal Authority / Responsibility and Justice: Beyond Moral Egalitarianism and Rational Consensus / Habermas’s and Rawls’s Postsecular Modesty / Part VI: The Difference Principle -- A Defense of the Difference Principle beyond Rawls / Marxist Critiques of the Difference Principle / Part VII: The Economic Perspective: Adam Smith -- Justice, Equity, and Distribution: Adam Smith’s Answer to John Rawls’s Difference Principle / Statism and Distributive Injustice in Adam Smith / Notes on Contributors -- Author Index -- Subject Index1 online resourc
Multi-functionalism, volunteers and the "school culture": adult educaiton in the Maltese contest
No full textKnoll,J.H., ed.Source type: Print(0
Deep Mean-Variance Hedging mittels LSTM RNNs
No full textDie Suche nach Hedging-Strategien für Derivate ist ein zentrales Problem der Finanzmathematik und sowohl für institutionelle als auch für private Investoren von großem Interesse. Herkömmliche Hedging-Verfahren erfordern in der Regel die Spezifikation und Kalibrierung eines Asset-Preis-Modells, bevor eine Hedging-Strategie berechnet werden kann. Als Alternative zu diesen Ansätzen haben Buehler et al. das Deep Hedging Framework basierend auf neuronalen Feed-Forward-Netzwerken eingeführt. Die vorliegende Arbeit adaptiert dieses Framework in zwei Bereichen. Erstens ist das Netzwerk, das zur Bestimmung der Hedging-Strategie verwendet wird, nicht mehr eine Folge verbundener neuronaler Feed-Forward-Netzwerke. Stattdessen wird eine echte rekurrente Topologie verwendet, die aus hierarchisch angeordneten long short-term memory (LSTM) Zellen besteht. Zweitens wird das Hedging-Optimierungsproblem als ein Mean-Variance-Hedging-Problem formuliert, bei dem das Ziel darin besteht, den erwarteten quadratischen Hedging-Fehler unter einem äquivalenten Martingal-Maß zu minimieren. Dieser Ansatz kann auch Marktfriktionen in Form von Transaktionskosten und Handelsrestriktionen in das Optimierungsproblem einbeziehen, d.h. Phänomene der realen Welt, die in traditionellen Hedging-Ansätzen normalerweise nicht berücksichtigt werden. Eine Implementierung des LSTM-basierten Ansatzes wird in numerischen Experimenten unter vier verschiedenen Rahmenbedingungen und zwei verschiedenen Klassen von Asset-Preis-Modellen illustriert und bewertet, wobei das neuronale Netzwerk basierend auf dem Loss bei Out-of-Sample-Testdaten ähnliche oder bessere Performance erzielt als die Benchmark-Strategien.Finding hedging strategies for derivatives is a central problem of mathematical finance and of great interest for both institutional and retail investors. Traditional hedging techniques usually require specification and calibration of an asset price model prior to calculating a hedging strategy. As an alternative to these approaches Buehler et al. introduced the Deep Hedging framework based on feed-forward neural networks. This thesis adapts this framework in two areas. First, the network used to determine the hedging strategy is no longer a sequence of connected feed-forward neural networks. Instead, a truly recurrent topology consisting of hierarchically organized long short-term memory (LSTM) cells is used. Secondly, the hedging optimization problem is formulated as a mean-variance hedging problem, where the aim is to minimize the expected squared hedging error under an equivalent martingale measure. This approach can also incorporate market frictions in the form of transaction costs and trading constraints into the optimization problem, i.e., real-world phenomena which are usually not considered in traditional hedging approaches. An implementation of the LSTM-based approach is illustrated and evaluated in numerical experiments under four different settings and two different classes of asset price models, where the neural network performs similarly or better than the benchmark strategies, based on the loss on out-of-sample test data
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