2,320 research outputs found
Promotion of cell chimerism by immunosuppressive drugs: A possible basis for tolerance induction following organ transplantation
No full textSuppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production.
No full textInfluence of temperature and sliding speed on the subsurface microstructure evolution of EN AW-6060 under sticking friction conditions
No full textThis article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in AIP Conference Proceedings 1896, 140012 (2017) and may be found at https://doi.org/10.1063/1.5008168.The microstructure evolution of the friction boundary layer of the aluminum alloy EN AW-6060 was investigated. Sticking friction tests at different temperatures and sliding speeds were carried out. A severe deformation below the friction surface was observed by means of LOM and EBSD mapping. Thus, the thickness variation and the grain structure of the high deformation zone could be described. Fibrous structure was observed at 300 °C and 400 °C, while equiaxed grains with high misorientation angle (>15°) were generated at higher temperatures. Additionally, abnormal grain growth and coarse grains were detected at high sliding speeds (10 mm/s, 42 mm/s) at 450°C and 500 °C respectively
Functional modification of CD11c+ liver dendritic cells during liver regeneration after partial hepatectomy in mice
No full textLocal immunosuppression within the liver and sex steroid changes, in both blood and tissue
during liver regeneration, are well-recognized events. Dendritic cells (DC) play pivotal roles
in the induction and regulation of immune responses. Their numbers are expanded markedly
in vivo by fms-like tyrosine kinase 3 ligand (Flt3L) administration, without modification
of their maturation state. Recent evidence suggests that estrogen can modulate DC
function and promote a Th2-type immune response. Few data are available concerning the
role ofDCin liver regeneration. After 75% partial hepatectomy (PH) inmale C57BL/6 mice,
CD11c+ liver (L)DC increased significantly within 6 hours and maintained an immature
phenotype. Numbers returned to pre-hepatectomy levels by 24 hours. The expanded LDC
population showed increased IL-10 and reduced IFN-gamma gene transcription. Using these DC
compared with control LDC as T cell stimulators in 72-hour mixed leukocyte cultures, IL-10
production was enhanced and IFN-gamma production reduced. LDC isolated 6 hours after 75%
PH exhibited enhanced estrogen receptor (ER) expression, concomitant with increased
serum estrogen levels. By contrast, spleen (S)DC isolated before and after PH showed no
significant changes in their function (maturation state, T cell stimulatory activity, cytokine
production, and ER expression). Increased liver regeneration (more than 50%) was observed
48 hours after 40%PHin the Flt3L-pretreated compared with the PBS group. In conclusion,
interstitial LDC may play a key role in local immune regulation during liver regeneration,
possibly linking estrogen-mediated immune modulation and hepatocyte proliferation
Author-Suggested, Weighted Citation Index: A Novel Approach for Determining the Contribution of Individual Researchers
No full textA novel scientometric index, named ‘author-suggested, weighted citation index’ (Aw-index) is proposed to indicate the scientific contribution of any individual researcher. For calculation of the Aw-index, it is suggested that during the submission of a scholarly article, the corresponding author would provide a statement, agreed upon by all the authors, containing weightage factors against each author of the article. The author who contributed more to the article would secure a higher weightage factor. The summation of the weightage factors of all the authors of an article should be unity. The citation points a researcher receives from a scholarly publication is the product of his/her weightage factor for that article and the total number of citations of the article. The Aw-index of any individual researcher is the summation of the citation points he/she receives for all his/her publications as an author. The Aw-index provides the opportunity to the group of authors of a multi-authored article to determine the quantum of partial citations to be attributed to each of them. Through an illustrative example, a comparison of the proposed index with the major scientometric indexes is presented to highlight the advantages of the Aw-index
The fibroblast growth factors.
No full textWe have reviewed data showing that FGFs are a family of related factors playing fundamental roles in several biologic processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, and chronic inflammation and cancer. These processes are dependent on several biologic responses mediated by FGFs, including cell survival, proliferation, migration, invasion and differentiation
Influence of Process Parameters on the Quality of Aluminium Alloy EN AW 7075 Using Selective Laser Melting (SLM)
No full textAbstractSelective laser melting (SLM) is an additive manufacturing process, forming the desired geometry by selective layer fusion of powder material. Unlike conventional manufacturing processes, highly complex parts can be manufactured with high accuracy and little post processing. Currently, different steel, aluminium, titanium and nickel-based alloys have been successfully processed; however, high strength aluminium alloy EN AW 7075 has not been processed with satisfying quality. The main focus of the investigation is to develop the SLM process for the wide used aluminium alloy EN AW 7075. Before process development, the gas-atomized powder material was characterized in terms of statistical distribution: size and shape. A wide range of process parameters were selected to optimize the process in terms of optimum volume density. The investigations resulted in a relative density of over 99%. However, all laser-melted parts exhibit hot cracks which typically appear in aluminium alloy EN AW 7075 during the welding process. Furthermore the influence of processing parameters on the chemical composition of the selected alloy was determined
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