1,008 research outputs found
Stith Thompson S268: «Ami et Amile»
No full textIl racconto di "Ami et Amile" nella versione in anglo-normanno è analizzato alla luce dei motivi antropologici catalogati dal repertorio di Stith Thompson. In particolare l’indagine si sofferma sul motivo S268: Child sacrified to provide blood for cure of friend e alle analogie con Le Réconfort de madame du Freisne di Antoine de la Sale
Le rappresentazioni dei neri nell’età moderna : temi e questioni metodologiche
No full textl volume costituisce una novità assoluta nel panorama editoriale del nostro paese perché affronta forme e contesti della rappresentazione dei neri in età moderna, finora rimasti molto marginali, se non pressocché assenti, nelle ricerche storico-artistiche italiane. Il libro, composto da saggi di Giuseppe Patisso, Cinzia Maria Sicca, Geoffrey Quilley, Chiara Savettieri, Bruno Chenique e Justin Randolph Thompson, non ha pretese di completezza, ma l’obiettivo primario di far emergere, attraverso alcuni casi emblematici, temi – dal XVI secolo fino a Géricault – e soprattutto questioni metodologiche legate a questo argomento, mostrandone le implicazioni politiche e richiamando il ruolo cruciale dello storico, il cui compito è portare alla luce ciò che è stato ignorato, e dunque annullato, nelle riscritture occidentali della storia dell’arte. Perché la marginalizzazione negli studi non è altro che il riflesso di una marginalizzazione sociale e politica
Sir Themistocles Zammit : his honours and an annotated bibliography of his medical work
No full textSir Themistocles Zammit was born 30th September 1864 and died 2nd November 1935. Dr. Paul Cassar wrote that Zammit “is, in my view, Malta’s most distinguished man”. He was scientist, doctor, chemist, archaeologist, writer and statesman, yet there has been no proper biography of him and no complete list of his publications and only few of his personal papers survive. It is difficult to trace his career and there seem to be few reminiscences about him. In this article the author compiles an annotated bibliography of the medical papers of Sir. T. Zammit.peer-reviewe
Primary Rules On The Way To Primary Schools: An assessment on the role of car speed reduction policy on creating a subjectively safe and encouraging environment for cyclists in the school zones
No full textWith an increase in interest in putting people on bikes instead of driving vehicles for day-to-day transport, new regulations are being implemented to make roadways safer for cyclists while also encouraging cycling behavior among various segments of the population. The perception of safety has been proven to play a significant role in the decision to adopt active forms of transportation. The significance of this feeling is underlined even more when it comes to vulnerable road users, in this case, cycling children. This study seeks to provide a better knowledge of the road conditions that increase the perception of road safety in order to establish a safe and encouraging cycling environment for adolescents cycling to school. The preferences of different categories of the population toward various measures are explored using the stated preferences experiment. Furthermore, with the adoption of the new lowering of the speed limit policy, the attitude toward a growth in the usage of bicycles is done. According to the findings of this study, different sectors of the public have distinct perceptions and preferences toward the numerous aspects shown on the highways. The presence of separated bike lanes, a speed restriction of 30 km/h, and a priority for crossing rule for cyclists are discovered to be components that all groups in the sample strongly prefer. Parking on the country road is limited to the groupings of parents and road designers. Finally, the presence of speed displays is discovered to be negligible for all subgroups in the sample population as a measure that has no influence on making roads safer for children to cycle on. Furthermore, it has been discovered that parents who bring their children to schools thatare now located near unsafe GOW50 roads have a more positive attitude toward cycling following the implementation of the speed limit policy. More aspects that were discussed in the GOW30 debate could be included in a future study to gain a better understanding of the impact of the various elements on providing a safe cycling environment for children. Furthermore, a recommendation is made to examine the behavior of parents in other locations that are also in close proximity to hazardous GOW50 roads and to incorporate the features of other respondents in order to corroborate the findings of this study.Transport, Infrastructure and Logistic
The synthesis and characterization of processable precursor polymers to articulated polyfphenylene benzobisoxazoles containing the 2.5-disubstituted-1.4-bicyclor2.2 21 octyl ring system., 1995
No full textProcessable precursor polymers to articulated poly(phenylene benzobisoxazoles), PBOs, have been prepared and studied. The precursor polymers were synthesized by the polycondensation of l,4-bicyclo[2.2.2]octyl-2,5-diethanoate dicarboxylic acid or 1,4- bicyclo[2.2.2]octyl-2,5-diol dicarboxylic acid with 3,3'-dihydroxy-4,4'-diaminobiphenyl or 2,2'-bis(3-amino-4-hydroxyphenyl)hexafluoropropane in poly(phosphoric acid), PPA. The precursor polymers were characterized by solubility, viscosity, spectroscopy (infrared, proton and carbon-13 NMR) and thermal analysis such as, differential scanning calorimetry, thermogravimetric analysis and optical polarizing microscopy. Thermogravimetic analysis (TGA) indicates that the precursor polymers are generally stable up to ca. 220� and 350� in air and under nitrogen atmosphere, respectively. Conversion of the precursor polymers to the more stable poly(phenylene benzobisoxazoles) is achieved by pyrolysis in air or under nitrogen atmosphere
Gli enigmi della forma. Un’indagine morfologica tra biologia ed estetica
No full textA partire dall’analisi di “On Growth and Form”, l’imponente opera di D'Arcy Thompson, emergono i principali temi che fanno della morfologia una scienza ancora immatura, che cerca una propria identità tra estetica ed epistemologia. Un’identità che sembra più volte smarrirsi nella fluttuante metamorficità delle forme stesse, nella loro contingenza, anche se proprio il tentativo di legalizzare la forma unisce in un comune sforzo Leibniz a Goethe, Bonnet a Buffon, Etienne Geoffroy Saint-Hilaire a Owen, D'Arcy Thompson a René Thom
Design and Synthesis of Novel Candidate CK1δ Proteolysis Targeting Chimeras (PROTACs)
No full textThe dysregulation of CK1 isoforms is linked to various types of diseases, including neurodegeneration and different types of neoplasia such as colon, pancreatic, breast, and ovarian cancer. For CK1 isoforms, a plethora of effective small molecule inhibitors are available. However, only a few degraders of CK1α and, more recently, proteolysis targeting chimeras (PROTACs) for CK1δ/CK1ε have been reported. In this study, we applied the PROTAC concept by harnessing molecular modelling to design and synthesize a series of candidate CK1δ-targeting PROTACs based on a highly specific and potent benzothiazole-based CK1δ inhibitor that we previously developed in our lab. In the present study, we established a modular synthetic platform to systematically generate a set of PROTAC degrader candidates consisting of the CK1δ-specific inhibitor scaffold, alkyl and PEG linker motifs with various lengths, and Cereblon (CRBN)-engaging pomalidomide and thalidomide derivatives as E3 ligase binders. We demonstrate that several PROTACs degrade CK1δ/ε in various cells. The most potent PROTAC P1d inhibits the phosphorylation of downstream substrates through CK1δ/ε degradation. We establish the requirement of CUL4ACRBN and the proteasome for the P1d-mediated degradation of CK1δ/ε
Prologhi di Architettura. Temi e attori del teatro urbano Prologues of Architecture. Themes and Actors of the Urban Theater
No full textDodici, come i semitoni che compongono un’ottava musicale, i Prologhi riportati in questo volume in forma di monologo, intendono offrire spunti, dubbi, idee sui temi della pianificazione urbana, delle strategie rigenerative per il territorio e del ruolo dell’architettura nella configurazione di un rinnovato paesaggio costruito in opposizione all’imperante attuale scissione tra forme e contenuti. Rigenerazione, infrastrutture, continuità, tettonica, innovazione, resilienza, materia, misura, costruzione, spazio, tempo, eteronomia evidenziano i temi cardine della riflessione condotta dall’autore nel cuore della disciplina, ingredienti imprescindibili di una ricerca teorica e progettuale in cui la memoria è l’elemento di dialogo tra storia, contemporaneità e nuove ibridazioni. Ne emergono temi e attori di un teatro urbano in grado di alimentare il dibattito sull’architettura, sul suo farsi attuale e nel suo essere in continua evoluzione.Twelve, like the semitones that make up a musical octave, the Prologues presented in this volume in monologue form seek to offer insights, doubts and ideas about issues in urban planning, regenerative strategies for the territory and the role of architecture in configuring a renewed landscape built in opposition to the current prevailing scission between forms and contents. Regeneration, infrastructure, continuity, tectonics, innovation, resilience, matter, measure, construction, space, time, and heteronomy bring out key themes of the reflection conducted by the author in the heart of the discipline, essential ingredients of a theoretical and purposeful research in which memory is the element of dialogue between history, contemporaneity, and new hybridizations. The book highlights themes and actors of an urban theater capable of fostering debate on architecture, on its becoming relevant and timely and its steady evolution
Redevelopment after the Abruzzo event
No full textNatural disasters raise quite a number of interdisciplinary issues concerning regional economic growth and local development, as well as public finance and sustainability, to mention only a few of them. These issues deserve special attention in our globalized world, given the expectation of a growing impact of climate-related disasters: no surprise that disaster management stands as a new discipline aimed at bridging the gap between theory and practice, so as to prevent natural disasters in the first place; afterwards, considerable efforts are required to accelerate business recovery, quickly restore vital energies, and hopefully carry out specific improvement projects as a sort of compensation for the (both personal and economic) losses suffered. Interesting lessons can be learned from natural disasters and can be shared as a payback to those who helped upon their occurrence. Actually, cooperation calls for cross-cultural activities that are likely to benefit from direct experience made by impacted scholars and practitioners: a case in point has to do with the earthquake that devastated L’Aquila and its environs on April 6, 2009 causing more than 300 deaths, apart from extensive damage in the Abruzzo region, in Central Italy; the Abruzzo event – as this natural disaster is currently referred to – fuels the debate on redevelopment problems to be faced under similar circumstances, that may obliterate the economic environment and attractiveness of an area in a few moments. Due to the huge amount of money needed to undertake appropriate strategies, finance plays a key role and useful insights can be gained by exploring the process of financial innovation. A supporting argument deals with the recourse to micro-finance in order to make the business and economic scenario revive after a natural disaster: micro-credit might be resorted to even within the framework of new financial engineering instruments, such as Urban Development Funds, recently promoted by the European Investment Bank; they include JESSICA (Joint European Support for Sustainable Investment in City Areas) and JEREMIE (Joint European Resources for Micro to Medium Enterprises), to be properly considered as strategic tools in sight of redeveloping L’Aquila and its surrounding boroughs.
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