2,410 research outputs found
Prescribing and medicines management ‘Down Under’
No full textIn the first in a series of three articles, Angus Thompson introduces his reflections on some of the differences in prescribing and medicines management between the UK and Australia
Cephalosporins - do they still have a role in primary care
No full textCephalosporins are barely mentioned in the HPA's guidance on treating infection and there is rising concern over their role in the development of C. difficile. Angus Thompson argues that, with suitable alternatives available, there is little reason to continue prescribing them
IFT88 influences chondrocyte actin organization and biomechanics
No full textAngus Wann was supported on an ARUK project grant (Ref No. 19830) at Queen Mary University of London before moving to Oxford. Clare Thompson is currently funded on an MRC project grant (Ref No. MR/L002876/1)
The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading
No full textArticular cartilage, like many other living tissues, experiences a complex physiological mechanical loading environment which regulates cell function and tissue homeostasis through a process of mechanotransduction. The underlying signalling pathways and mechanotransduction mechanisms are poorly understood but recent studies point to the involvement of a fascinating and previously over looked cellular organelle called the primary cilium. In other cell types, including epithelial cells and osteocytes, primary cilia have been shown to function as mechanoreceptors. This appears to involve deflection of the cilium in response to fluid shear forces which then activates calcium signalling pathways. In this chapter we examine the structure and function of the primary cilium and its potential role in mechanotransduction in articular chondrocytes. In particular we review exciting recent studies which suggest that the primary cilium mediates chondrocyte mechanotransduction through regulation of purinergic calcium signalling leading to changes in extracellular matrix synthesis. Furthermore we examine how other cilia-mediated mechanotransduction pathways, most notably hedgehog signalling, are also regulated by mechanical forces thereby controlling cell proliferation and tissue development. Finally we describe the regulation of primary cilia structure and how mechanical forces may influence the complex balance of cilia assembly and disassembly leading to alterations in cilia function. In summary this chapter explores the rapidly evolving area of primary cilia and their response to mechanical forces with a particular focus on articular cartilage for which mechanical loading is critical for homeostasis and functionality. Understanding the role of the primary cilium in mechanobiology will aid the development of novel therapeutic strategies for pathologies, such as osteoarthritis, that involve disruption of primary cilia function.</p
Fat distribution in angus steers is related to residual feed intake estimated breeding value
No full textThe association between fat distribution and feed efficiency was investigated using Angus steers divergent in residual feed intake (RFI) estimated breeding values (EBV). The 208 steers were fed in a commercial feedlot in NSW for 250 days, entering at 13 – 16 months of age. Hot standard carcass weight, eye muscle area, marble score, intramuscular fat content, rib fat (subcutaneous) depth and seam (intermuscular) fat area were measured and regressed against the mid-parent RFI EBV of the steers. The results showed that rib fat depth was more strongly associated with RFI EBV than were the other fat depots.A.R. Egarr, W.S. Pitchford, M.J. Bottema, R.M. Herd, J.P. Siddell, J.M. Thompson and C.D.K. Bottem
'Arts Commission Budget' memo to Gov. Atiyeh
No full textA memo prepared by Gerry Thompson reporting to Governor Atiyeh on December 16, 1981. This report addresses the Arts Commission budget review, budget proposal, and staff cuts. Angus Randolph, overseer of community networking for the Arts Commission, is listed as a dispensable employee. This is one document from a binder containing selected daily reports to the Governor, which was compiled by Gerry Thompson
Autumn leaves : sound and the environment in artistic practice
No full textThis publication is a book that represents an innovative, international and multi-disciplinary approach to conceptualising the dynamic relationships between sound and the environment. The editorial process involved directly commissioning textual, graphic and photographic work. The vast majority of the book represents new work, produced specifically for this publication. For the purposes of tracing historical development, an article from 1974 and three older projects have been revived and recontextualised. In addition to the editorial responsibility, the researcher wrote the introduction and conducted three original interviews. The book draws work from visual, sound and performance art, acoustic science, anthropology, cultural studies, public policy, and architectural theory. Just as it is true to say that these disciplines have not previously been brought together in this way, equally, it is no exaggeration to identify the contributors as the leading international lights in the field: Chris Watson, Tim Ingold, Hildegard Westerkamp, Christina Kubisch, Alvin Lucier, David Toop. The book is published by Double Entendre, the French publisher of the premier sound arts journal, Vibro. The book is accompanied by an audio compilation published by the German record label, Gruenrekorder (Gruen 053). www.autumn-leaves.gruenrekorder.de. The researcher co-curated the compilation, selecting relevant work that illustrated the book’s themes. The book was the catalyst for a one-day symposium at the Tate Britain called The Performance of Sound (May 19th, 2006), which the researcher co-organised. The researcher was invited to speak on the book at the Audio Extranautes: Flux, Distance, Sociability symposium at the Villa Arson in Nice in December 2007. Autumn Leaves has been reviewed in the French journal Mouvement; in MCD where the reviewer reported that “this book deserves to be translated into French”; and Soundscape: The Journal of Acoustic Ecology. Soundscape 7 (1), Autumn, 2007 reprinted an interview conducted by the author from the book. Autumn Leaves, edited by CRiSAP co-director Angus Carlyle, seeks to draw together a number of different perspectives on how the environment is made audible through sound. The perspectives contained in the book are made manifest through more traditional textual analyses, interviews, image-based works (both photography and graphic illustration) and ‘artist’s pages’ (which combine different registers of information).
Among the articles included in the book are a superb deconstruction of the concept of soundscape by anthropologist Tim Ingold; an intriguing analysis of sound from an acoustic point-of-view (or point-of-audition) by Bill Davies; Steve Goodman’s dynamic opening up of city sound to a bass materialism provoked by Greg Lynn’s ‘blob’ architecture; Salome Voegelin’s evocative mapping of sci-fi aesthetics onto the project of acoustic ecology; a wonderful meditation on the heard and the unheard by David Toop; Sylvain Marquis powerfully drawing out the ‘presence’ of Phill Niblock; Rahma Khazam finding new ways of listening through an inspired conceptual conversation between art, architecture and relational aesthetics; and a re-print of Hildegard Westerkamp’s pioneering discussion of soundwalking from 1974.
Interviews include a wide-ranging discussion with Alvin Lucier about his work and working practices; an exploration of Christina Kubisch’s long-standing commitment to teasing out the complexities of the sounds that surround us; Peter Cusack providing an exciting account of his Sound of Dangerous Places project; Chris Watson talking us through his inspirational field-recording; and Max Dixon offering fresh perspectives on how the development of strategies for noise in urban environments meshes policy with research into bio-acoustics, acoustics and creative practice.
Images include Dan Holdsworth’s haunting representations of anechoic chambers through Charles Fox’s photographs of microphone arrays in the wilderness, Axel Stockburger’s ASCII art evocations of video-game space and Nicholas Gansterer’s intricate diagrams of our heard world.
What remains of the book is devoted to the artists’ pages. In these a whole host of contemporary practitioners spanning the disciplines of graphic design, music, photography, performance and visual art offer their provocative takes on sound and the environment. Here we encounter John Wynne and Tim Wainwright presenting their collaborative work in Harefield Hospital; Aki Onda pursuing his Cinemage project; Claudia Wegener finding poetry in ear- and eye-witnessing; an unpacking of the theories and technologies behind the exciting Locus Sonus audio streams; NYSAE opening up its portfolio of acoustic ecology-inspired activities; Goran Vejvoda mobilising a modular manifesto from his three decades of sound art; the Gruenrekorder label reviewing the thinking behind its 40 releases; Jem Finer show-casing his Score For A Hole in the Ground; Cathy Lane mapping her memories of the Hebrides; Zoe Irvine making an art of places out of abandoned audio tape; and Mira Choi introducing her noise-responsive graphic software.
The editorial work and its presentation has been a collaborative venture with the designer Ian Noble.
Autumn Leaves is CRiSAP's first book and is edited by CRiSAP Co-Director Angus Carlyle[/b] and published by the exciting French sound art initiative Vibro / Double Entendre. It contains work by a variety of artists including several of CRiSAP's members - Salomé Voegelin, John Wynne, Peter Cusack, Cathy Lane and David Toop
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.
No full textBACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β). We have also shown the primary cilium elongates in response to IL-1β exposure. Both anabolic phenotype and inflammatory pathology are proposed to be dependent on hypoxia-inducible factor 2 alpha (HIF-2α). The present study tests the hypothesis that an association exists between the primary cilium and HIFs in inflammatory signalling. RESULTS: Here we show, in articular chondrocytes, that IL-1β-induces primary cilia elongation with alterations to cilia trafficking of arl13b. This elongation is associated with a transient increase in HIF-2α expression and accumulation in the primary cilium. Prolyl hydroxylase inhibition results in primary cilia elongation also associated with accumulation of HIF-2α in the ciliary base and axoneme. This recruitment and the associated cilia elongation is not inhibited by blockade of HIFα transcription activity or rescue of basal HIF-2α expression. Hypomorphic mutation to intraflagellar transport protein IFT88 results in limited ciliogenesis. This is associated with increased HIF-2α expression and inhibited response to prolyl hydroxylase inhibition. CONCLUSIONS: These findings suggest that ciliary sequestration of HIF-2α provides negative regulation of HIF-2α expression and potentially activity. This study indicates, for the first time, that the primary cilium regulates HIF signalling during inflammation
Founding the Sunshine Coast Mind and Neuroscience - Thompson Institute
No full textThis booklet gives a detailed account of the raising of funds and the appointment of Staff for the Institute. It highlights in particular the role of Mr Roy Thompson in providing very substantial funds for the Institute as well as the Institute’s Foundation, chaired initially by Sir Angus Houston
Seabed foraging by Antarctic krill: Implications for stock assessment, bentho-pelagic coupling, and the vertical transfer of iron
No full textA compilation of more than 30 studies shows that adult Antarctic krill (Euphausia superba) may frequent benthic habitats year-round, in shelf as well as oceanic waters and throughout their circumpolar range. Net and acoustic data from the Scotia Sea show that in summer 2-20% of the population reside at depths between 200 and 2000 m, and that large aggregations can form above the seabed. Local differences in the vertical distribution of krill indicate that reduced feeding success in surface waters, either due to predator encounter or food shortage, might initiate such deep migrations and results in benthic feeding. Fatty acid and microscopic analyses of stomach content confirm two different foraging habitats for Antarctic krill: the upper ocean, where fresh phytoplankton is the main food source, and deeper water or the seabed, where detritus and copepods are consumed. Krill caught in upper waters retain signals of benthic feeding, suggesting frequent and dynamic exchange between surface and seabed. Krill contained up to 260 nmol iron per stomach when returning from seabed feeding. About 5% of this iron is labile, i.e., potentially available to phytoplankton. Due to their large biomass, frequent benthic feeding, and acidic digestion of particulate iron, krill might facilitate an input of new iron to Southern Ocean surface waters. Deep migrations and foraging at the seabed are significant parts of krill ecology, and the vertical fluxes involved in this behavior are important for the coupling of benthic and pelagic food webs and their elemental repositories
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