10,745 research outputs found
Thomas-Morse MB-3
No full text1/4 left side view of a Thomas-Morse MB-3, a military plane, on the ground.https://corescholar.libraries.wright.edu/special_ms344_photographs/1534/thumbnail.jp
Thomas Morse MB-7
No full text1/4 left hand side view of the Thomas Morse MB-7, a racing aircraft, on the ground. This aircraft was entry number 7 in the 1922 Pulitzer Race.https://corescholar.libraries.wright.edu/special_ms223_photographs/1493/thumbnail.jp
Thomas-Reiche-Kuhn populations in alkanes
No full textAtomic populations in a molecule have been defined via the 'Thomas-Reiche-Kuhn sum rule for oscillator strengths written within the acceleration gauge. These atomic populations are related to nuclear electric shieldings, i.e., to geometrical derivatives of electric dipole moment, and can therefore be connected with observable infrared intensities. A number of relationships can be considered to test a priori the quality of calculated electronic charges and to assess their physical meaning. It is shown via extended numerical tests on the first members of the alkane series that the Thomas-Reiche-Kuhn populations are consistent with a (small) polarity C+-H- of carbon-hydrogen bond in methane, for which a bond dipole moment can be exactly defined. Although the idea of bond dipole cannot be extended to the C-H fragments belonging to other alkane molecules in the absence of local C-3v symmetry, the calculations prove that the same electron charge polarization should characterize the whole homologous series. (C) 1999 Elsevier Science B.V. All rights reserved
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Letter From Emmett L. Bennett Jr. to Thomas G. Palaima, October 24, 1994
No full textBennett tells Palaima of his attempt to get 8 MB of RAM bought for his computer. He also attaches a letter addressed to Pierre Carlier requesting the provenance of a photo of Pylos tablet PY An 656 in Victor Duruy's Die Welt des fruhen Griechenland.Classic
A History of the Church of Saint Thomas, 1836-1936
No full textBased upon 'The Church of St. Thomas and its Rectors' by the late H.W. LeMessurier, C.M.G., published in 1928. Now amended and added to by the Centenary Historical Committee, R.G. MacDonald, Chairman. Published on the occasion of the Centenary Celebration of the Founding of the Church, September 21st, 1936, St. John's, Newfoundland
MB-based trafficking of fatty acids.
No full textMB in MCF7 (A) and MDA-MB468 (B) cells controls the transport of a fluorogenic palmitate derivative (BODIPY-FL C16) between cytoplasm and vesicular depots in an O2-dependent fashion. Cells were incubated with BODIPY (green) for 30 min before exposure for 72 hrs to normoxia (Nx, air, oxygenated MB) or severe hypoxia (Hx, 0.2% O2, deoxygenated MB). The nuclei of MCF7 cells were stained with DAPI (blue). The figures shown are the representative of 6 independent experiments. Scale bar: 10 μm. Magnification: 63x. (C) MBwt and MBko MDA-MB468 cells incubated under normoxia (Nx) or severe hypoxia (Hx) were co-stained with BODIPY and a lysosome marker (Cytopainter red). The figures shown are representative of 3 independent experiments. Scale bar: 10 μm. Magnification: 63x. MBko (Nx) cells were stained by DAPI for nuclei. (D) Lysosomal (Cytopainter red) staining in MDA-MB468 cells was analysed by FACS measurement with the signal intensity expressed as geometric mean (X-GMean). Students t-test was used for statistics (n = 5); mean ± SD. *p≤0.05.</p
MAGPIE/EGRET annotation of the 2.9-Mb Drosophila melanogaster Adh region
No full textGaasterland T, Sczyrba A, Thomas E, Kurban G. MAGPIE/EGRET annotation of the 2.9-Mb Drosophila melanogaster Adh region. Genome Res. 2000;10(4):502-510
The infectivity of the entomopathogenic fungus Beauveria bassiana to insecticide-resistant and susceptible Anopheles arabiensis mosquitoes at two different temperatures
No full textBACKGROUND: Control of the major African malaria vector species continues to rely extensively on the application of residual insecticides through indoor house spraying or bed net impregnation. Insecticide resistance is undermining the sustainability of these control strategies. Alternatives to the currently available conventional chemical insecticides are, therefore, urgently needed. Use of fungal pathogens as biopesticides is one such possibility. However, one of the challenges to the approach is the potential influence of varied environmental conditions and target species that could affect the efficacy of a biological 'active ingredient'. An initial investigation into this was carried out to assess the susceptibility of insecticide-susceptible and resistant laboratory strains and wild-collected Anopheles arabiensis mosquitoes to infection with the fungus Beauveria bassiana under two different laboratory temperature regimes. METHODS: Insecticide susceptibility to all four classes of insecticides recommended by WHO for vector control was tested on laboratory and wild-caught An. arabiensis, using standard WHO bioassay protocols. Mosquito susceptibility to fungus infection was tested using dry spores of B. bassiana under two temperature regimes (21 +/- 1 degrees C or 25 +/- 2 degrees C) representative of indoor conditions observed in western Kenya. Cox regression analysis was used to assess the effect of fungal infection on mosquito survival and the effect of insecticide resistance status and temperature on mortality rates following fungus infection. RESULTS: Survival data showed no relationship between insecticide susceptibility and susceptibility to B. bassiana. All tested colonies showed complete susceptibility to fungal infection despite some showing high resistance levels to chemical insecticides. There was, however, a difference in fungus-induced mortality rates between temperature treatments with virulence significantly higher at 25 degrees C than 21 degrees C. Even so, because malaria parasite development is also known to slow as temperatures fall, expected reductions in malaria transmission potential due to fungal infection under the cooler conditions would still be high. CONCLUSIONS: These results provide evidence that the entomopathogenic fungus B. bassiana has potential for use as an alternative vector control tool against insecticide-resistant mosquitoes under conditions typical of indoor resting environments. Nonetheless, the observed variation in effective virulence reveals the need for further study to optimize selection of isolates, dose and use strategy in different eco-epidemiological setting
A model showing how activation of fibroblasts leads to accelerated coalescence of MDA-MB-231 breast cancer cells in a 3D Matrigel environment.
No full textA. Activation of NHDFs and HPMFs to CC-NHDFs and CC-HPMFs, respectively, after exposure to a medium conditioned by MDA-MB-231 cells. B. Physical interactions between MDA-MB-231 cancer cells and CC-fibroblasts occur initially at the collagen 1/Matrigel interface but later throughout the 3D environment with CC-fibroblasts serving as scaffolds for MDA-MB-231 cell coalescence. C. Release of soluble signals by CC-NHDF and CC-HPMF cells accelerates coalescence of MDA-MB-231 cells.</p
CC-HPMFs exhibit altered morphology, altered gene expression, accelerate MDA-MB-231 coalescence and release elevated MMPs.
No full textA, B. Representative phase images of F-HPMF and CC-HPMFs. C. qRT-PCR analyses of the transcript levels of ten genes associated with fibroblast activation. Means and error bars (standard deviations) are presented for N = 3. Asterisk (*) indicates significance of p <0.05. D. Representative fields after 24 hrs of aggregating MDA-MB-231 cells in which the MDA-MB-231/Matrigel phase is cast over F-HPMF cells on collagen and over CC-HPMF cells on collagen reveals larger aggregates in the latter. E. Substrate level, 10x magnification of representative fields of aggregating MDA-MB-231 cells over F-HPMF cells on collagen and over CC-HPMF cells on collagen reveals advanced coalescence and considerably more destruction of the CC-HPMF monolayer (dashed red line) in comparison to F-HPMF monolayer. F. Representative images of aggregating MDA-MB-231 cells cast over F-HPMF cells on collagen and over CC-HPMF cells on collagen at 72 hours at the 50 μm level demonstrate significantly larger aggregates over the CC-HPMF layer (solid red line) in comparison to the F-HPMF layer. G. Measurements of aggregate areas at 72 hours in cultures in which the MDA-MB-231/Matrigel phase was cast over F-HPMF cells (gray), and CC-HPMF cells (yellow). The median area of each population is noted as a gray or yellow arrow, respectively. The difference between MDA-MB-231 aggregate areas was significantly greater (p< 0.00001) in the presence of CC-HPMFs when compared to F-HPMFs. H. Gel zymogram and quantitation of pixel intensities of MMPs in HPMF-GM directly from the bottle of sterile, unused media (no cells); F-HPMF-GM, media from 72 hour cultures of F-HPMFs; CC-HPMF-GM/MB-231, media from 72 hour MDA-MB-231 cultures; and CC-HPMF-GM/CC-HPMF, media from 72 hour CC-HPMF cultures.</p
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