10,462 research outputs found
Atelier Départements Tertiaires 2, GEA, TL
No full textRoblin Isabelle, Thomas Jacqueline. Atelier Départements Tertiaires 2, GEA, TL. In: Cahiers de l'APLIUT, volume 15, numéro 3, 1996. Langues et culture. p. 88
Thomas d'Aquin. Somme théologique. Tl: Introductions générales et 1e Partie
No full textLion Antoine. Thomas d'Aquin. Somme théologique. Tl: Introductions générales et 1e Partie. In: Archives de sciences sociales des religions, n°59/2, 1985. p. 307
The Application of Monochromatic Photoneutron Spectroscopy In An Examination of Nuclear Energy Levels of ¹⁸⁰Ta, ²⁰²Tl And ²⁰⁴Tl
No full textMonochromatic photons from in-core neutron capture sources of aluminum, copper, iron, nickel and chromium were used to initiate the (Υ,n) reaction on the ¹⁸¹Ta, ²⁰⁵Tl and ²⁰³Tl nuclei. The use of this method allows precise measurement of the Q values for the ¹⁸¹Ta(Υ,n) ¹⁸⁰Ta (7579 ± 2 Kev) and the ²⁰⁵Tl(Υ,n)²⁰⁴Tl (7549 ± 1 Kev) reactions. Comparison of the ¹⁸¹Ta(Υ,n) data with the ¹⁸⁰Ta(n,Υ) data confirms the existence of an isomeric state in ¹⁸⁰Ta at 73 ± 2 Kev. Over twenty previously unobserved levels in ¹⁸⁰Ta were populated with typically ²Kev precision in energy determination. Well-documented levels ²⁰⁴Tl were observed to also be populated. The total (Υ, cross sections were measured and the gamma ray strength functions were deduced for the stronger (Υ,n) channels. The small incident gamma ray energy spread of a few ev allows excitation of individual excited state resonances in ²⁰⁵Tl, while averaging over many compound resonances in ¹⁸¹Ta is observed. The number of degrees of freedom for a Porter-Thomas distribution of reduced widths was also estimated and gave some credence to the deduced Υ-ray strength functions. Attempts to assign spin and parity in the residual ¹⁸⁰Ta and ²⁰⁴Tl nuclei were thwarted by the assumption of a dominant electric-dipole absorption cross section, and by the half-integer ground state spins of the ²⁰⁵Tl and ¹⁸¹Ta targets.Doctor of Philosophy (PhD
TL-1 cells exhibit lower expression of the IFNGR1 and IFNGR2 compared to Jurkat T cells.
No full textThe surface expression of the IFNGR1 and IFNGR2 was determined using flow cytometry in the TL-1 cell line compared to Jurkat T cells, an IFN-γ responsive cell line. Representative flow cytometry histograms of (A) IFNGR1 and (B) IFNGR2 and (C) median fluorescence intensity (MFI) of IFNGR1 and IFNGR2 in TL-1 and Jurkat T cells are shown. (D) IFNGR1 and IFNGR2 transcripts were quantified using qPCR. Results were normalized to ubiquitin C (UBC), a housekeeping gene. Student’s T test was used to determine significance of TL-1 cells compared to Jurkat T cells. All data are presented as mean +/- Stdev (n = 3 biological replicates).</p
TL-1 cells are responsive to IFN-β, supporting a type II interferon-specific signaling defect.
No full textJurkat T cells (A) or IL-2-starved TL-1 cells (B) were treated with 5000 U/mL IFN-β or water (vehicle control) for the indicated time. TL-1 cells were also treated with 200 U/mL IL-2 as a positive control for induction of p-STAT1. p-STAT1, total STAT1, and β actin were measured using western blot. (C) Jurkat or TL-1 cells were treated with 5000 U/mL IFN-β or water for 6 h prior to RNA extraction. Induction of IFN-γ and STAT1 transcripts was quantified using qPCR. Results were normalized to UBC (a housekeeping gene) and then to the water control to demonstrate fold change. Student’s T test was used to determine significance compared to vehicle control. * = p<0.05, ** = p<0.01, *** = p<0.005, **** = p<0.001. Data are presented as mean +/- Stdev (n = 3 biological replicates).</p
TL 9000 quality management system
No full textBei der TL 9000 handelt es sich um ein, speziell auf die Anforderungen der Telekommunikationsbranche zugeschnittenes, umfassendes Qualitätsmanagement-System auf Basis des ISO DIN EN 9000 Standards, das mit dem Ziel entwickelt wurde bereits existierende Qualitätsmanagement Systeme zu integrieren und unter einem gemeinsamen Dach zusammen zu fassen.1 Was ist TL 9000? S.1 2 Die Handbücher S.2 3 Verbreitung S.3 4 Ziele des TL 9000 S.4 5 Struktur: Die fünf Ebenen des TL 9000 S.5-6 6 Anforderungen (Requirements) im TL 9000 S.7-8 7 Metriken (Measurements) im TL 9000 S.9-13 - 7.1 Software Installation and Maintenance (SWIM) measurements S.9-12 - 7.1.1 Beispiel: Metrik "Corrective Patch Quality (CPQ)" S.10-12 - 7.2 Übermittlung der Metriken an das QuEST Forum S.13 8 Zertifizierungssystem des TL 9000 S.14-15 9 Vergleiche zwischen TL 9000 und anderen Standards S.16 - 9.1 TL 9000 und DIN EN ISO 9000ff S.16 10 Einschätzung zum TL 9000 S.17 11 Nutzen und Kosten von TL 9000 S.18 Anhang S.19 - Glossareintrag S.19 Literatur S.20-2
Typhlops notorachius Thomas & Hedges, 2007, new species
No full textTyphlops notorachius new species (Figs. 8 H, 9 D–E) Holotype: MNHNCu 4551 (field tag number 191322), a male from 9.4 km W Imias, Guantánamo Province, Cuba, 5 meters, collected on 1 July 1990 by S. Blair Hedges, Richard Thomas, and Daniel McCallister. Paratypes: USNM 564799, a male, same collection data as holotype; USNM 564797 – 798, Playitas de Cajobabo, Guantánamo Province, Cuba, 0 meters, collected on 1 August 1989 by Richard Thomas and S. Blair Hedges. Diagnosis: A relatively large species of the Typhlops biminiensis group differing from T. biminiensis in having a rostral with an acuminate posterior edge, not broadly rounded. Also, the rostral has parallel sides and is not indented at apex of the snout (Fig. 8). Additionally, T. notorachius has a proportionately smaller rostral than the preceding species (T. biminiensis, T. arator, T. perimychus, and T. anousius) (Figs. 8, 10 A). The difference in body size between T. notorachius and T. perimychus is striking; not considering the associated specimen of the latter species (which may be a different species), all four specimens of T. notorachius (282– 301 mm TL) are larger than all 18 specimens of T. perimychus (130–280 mm TL). Because each species was collected at multiple localities and, in the case of T. perimychus, over four decades, we surmise that the body size difference is real and not the result of collecting bias. Also, T. notorachius differs from T. perimychus in having a greater anterior nasal width (ANTNAS/RW 1): 0.42–0.53 versus 0.34–0.39 in T. perimychus. From T. anousius, T. notorachius also differs in its point of scale row reduction: 15–40 % TL versus 2 % TL in T. anousius. Description: Snout smoothly rounded. Rostral broad and rounded in dorsal aspect, nearly as broad as long in most specimens (RW 1 /RL 1 0.78–0.87), nearly straightsided, parallel or widening somewhat posteriorly; not flared on apex; no labial flare. Anterior nasal width as a proportion of RW 1 0.42–0.53. Preocular angle 108–120 °, apex rounded; lower portion contacting labials 2 and 3 of upper labial series. OL 1 / 2 height, OS 0.23–0.34. Rostronasal pattern strongly divergent. Postocular 3–4 times higher than long. First parietal standard, spanning 2 scale rows or slightly less. Second parietal present and similar in width to the first or absent. TL to 301 mm. TL/TA 48–75. TL/MBD 45–57. Middorsal scales 475–529. Scale rows 24 reducing to 22 at 15–40 % TL. Coloration bicolor with dorsal pigmentation (pale brown) fading ventrad anteriorly but ending abruptly by dropping out of pigmented scales posteriorly; 9 (mode) to 11 pigmented scale rows at midbody. Distribution: Known only from the south coast of eastern (Oriente) Cuba, over an extent of about 27 km between the two known localities, east of Guantánamo Bay. The westernmost of the localities, 9.4 km W Imias, is about 30 km east of the type locality for Typhlops anousius (Fig. 11). Etymology: An adjective made from the Greek, notos, south, and rhachia, shore, meaning “of the southern shore.” The next new species having affinities with T. biminiensis also occurs on the southern coast of eastern Cuba. It may be known asPublished as part of Thomas, Richard & Hedges, Blair, 2007, Eleven new species of snakes of the genus Typhlops (Serpentes: Typhlopidae) from Hispaniola and Cuba, pp. 1-26 in Zootaxa 1400 on page 21, DOI: 10.5281/zenodo.17541
Typhlops contorhinus Thomas & Hedges, 2007, new species
No full textTyphlops contorhinus new species (Figs. 8 I, 9 F) Holotype: MNHNCu 4552 (field tag number 191296), a male from 4.9 km S La Tinta, Guantánamo Province, Cuba, 5 meters elevation, collected on 29 June 1990 by Richard Thomas, S. Blair Hedges, Emilio Alfaro, and Daniel McCallister. Diagnosis: A moderately large and slender species of the T. biminiensis group differing from all members of the species group in the Bahamas and Cuba in having a short rostral (Fig. 8), reflected in the high rostral indent (RI) value (Fig. 10 F), and a large preocular apical diameter (Fig. 10 C). The short rostral is also reflected in the width of the upper arm of the anterior nasal, which is relatively larger in T. contorhinus (ANT NAS/RW 1 = 0.49) than other species in the group except T. notorachius and T. anousius. It further differs from T. biminiensis in having a rostral with an acuminate posterior edge, not broadly rounded, and a more slender body (TL/MBD 63 versus 39–51). It differs from T. biminiensis, T. arator, and T. perimychus in having a narrower rostral (Fig 10 A) that is relatively broad on the apex of the snout (Fig. 8). From T. perimychus, it also differs in being larger (316 mm versus 280 mm TL), having more middorsal scales (502 versus 453– 496), and a more slender body (TL/MBD 63 versus 41–59). In body shape, it is more slender (TL/MBD 63) than T. notorachius, T. anousius, and T. arator (Table 2). From T. anousius, it also differs in having scale row reduction at 31 % TL rather than 2 % TL. From T. arator, it further differs in having 24 – 22 scale rows rather than 26 – 24 rows and in having fewer middorsal scales (502 versus 578–579). Description: Snout rounded, lobed. Rostral broad, nearly straightsided in dorsal aspect, sides curving mesiad to apex (RW 1 /RL 1 0.93), not flared on apex; moderate umbo; no labial flare. Anterior nasal width as a proportion of RW 1 0.49. Upper wing of anterior nasals broad, preocular angle relatively small (98 °), apex rounded; lower portion contacting labials 2 and 3 of upper labial series. OL 1 / 2 height, OS 0.24. Rostronasal pattern strongly divergent. Postocular very elongate by fusion (on each side) with a lower scale, extending well below bottom edge of ocular. First parietals relatively narrow and long (i.e., not transversely elongate), the width of two succeeding scale rows. Second parietals present and similar in size to the first. TL 316 mm. TL/TA 53. TL/MBD 63. Middorsal scales 502. Scale rows 24 reducing to 22 at 31 % TL. Coloration bicolor with dorsal pigmentation (medium brown) ending abruptly along a midlateral or dorsolateral line by dropping out of pigmentation on individual scales, resulting in a jagged line of separation between pigmented and nonpigmented scales along almost all of the length; nine pigmented scale rows at midbody. Distribution: Known only from the type locality, an otherwise xeric site along the Río Jauco in extreme eastern Cuba (Fig. 11). Etymology: From the Greek, kontos, short, and rhinos, nose, an adjective meaning shortnosed. The next new species having affinities with T. biminiensis occurs on the Maisi peninsula at the eastern end of Cuba. It may be known asPublished as part of Thomas, Richard & Hedges, Blair, 2007, Eleven new species of snakes of the genus Typhlops (Serpentes: Typhlopidae) from Hispaniola and Cuba, pp. 1-26 in Zootaxa 1400 on pages 21-22, DOI: 10.5281/zenodo.17541
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy
No full textNeurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear. We studied cell death in Tg4510 mice that reversibly express P301L mutant human tau and accumulate NFTs using in vivo multiphoton imaging of neurofibrillary pathology, propidium iodide (PI) incorporation into cells, caspase activation, and DNA labeling. We first observed that in live mice, a minority of neurons were labeled with the caspase probe or with PI fluorescence. These markers of cell stress were localized in the same cells and appeared specifically within NFT-bearing neurons. Contrary to expectations, the PI-stained neurons did not die during a day of observation; the presence of Hoechst-positive nuclei in them on the subsequent day indicated that the NFT-associated membrane disruption, as suggested by PI staining, and caspase activation do not lead to immediate death of neurons in this tauopathy model. This unique combination of in vivo multiphoton imaging with markers of cell death and pathological alteration is a powerful tool for investigating neuronal damage associated with neurofibrillary pathology
- …
