61 research outputs found
Astaxanthin: Senyawa Antioksidan Karoten Bersumber dari Biota Laut
No full textMeskipun berbagai jenis antioksidan dalam makanan telah berkontribusi dalam pencegahan penyakit, namun sejumlah riset yang telah dilakukan lebih memfokuskan pada tiga jenis antioksidan yakni vitamin E, vitamin C dan karotenoid karena berperan penting sebagai nutrien yang diperlukan dalam metabolisme tubuh manusia
SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE
No full textCrosslinked PEO hydrogel containing chitosan for wound dressing has been prepared by gamma radiation technique. Chitosan solutions with different concentration (0.5-2% w/v) have been blended with 5% aqueous solution of PEO and irradiated at the doses 20-40 kGy by gamma rays. The copolymers were characterized by Fourier transform infra red spectroscopy and their physico-chemical properties of hydrogels were evaluated in terms of gel fraction, swelling ratio, elongation at break and antimicrobial activities. It was found that under maximum condition of incorporation 1% chitosan with irradiation dose of 20 kGy, PEO-chitosan hydrogels with high gel fraction (85%), swelling ratio (10 g/g) and elongation at break (145%) were obtained. The examination of the microbe penetration shows that the prepared hydrogels can be considered as a good barrier against microbes. Thus, PEO-chitosan hydrogel showed satisfactory properties for use as a wound dressing
Properties of Sodium Alginate–Polyvinyl Alcohol Hydrogels Irradiated By Gamma Ray For Wound Dressing Materials
No full textA copolymer of sodium alginate (SA)–polyvinyl alcohol (PVA) was synthesized by gamma irradiation to make a hydrogel and study on its properties has been carried out. A series of 0.5% -2.0% (w/v) of SA solution and 10% (w/v) of PVA solution were prepared in separate tubes. Each of the SA solution was mixed with PVA solution, then it was irradiated with gamma ray at the doses of 30 kGy, 40 kGy, and 50 kGy (dose rate of 10 kGy/hour), respectively. The properties of hydrogels were evaluated comprising of the physical performance, gel fraction, swelling ratio, water evaporation, and pH. The results showed that increase of irradiation dose can increase the gel fraction, but increase of SA concentration can decrease the gel fraction. SA concentration of 1-2% with gamma ray irradiation dose of 30 kGy was a suitable condition to produce a good hydrogel with properties as follow, gel fraction of 75.83%-78.70%, swelling ratio of 69.12-80.14 g/g, and maximum water evaporated of 54.21-76.41%, the pH value ranged 5.60-5.65. The hydrogels produced are suitable to be used for wound dressing, especially for wet wounds, and can be applied for two days
Correlation between fucoxanthin contents in Turbinaria sp.and sea water nutrients at Binuangeun and Krakal Coasts
No full textFucoxanthin pigment is a potential compound in nutraceutical. It is commonly found in algaesuch as in Turbinaria sp.,a very abundant species in Indonesian coastal. To maximize theproduction of fucoxanthin for the development of nutraceutical industry in the coastal area, it isimportant to identify the optimal environmental parameters for its biosynthesis. It has been reportedthat nitrogen and or phosphate nutrients affect the growth of algae. Therefore, this paper aimed toobtain an optimal environment for Turbinaria sp. to produce fucoxanthin based on correlationanalysis. Correlated data were fucoxanthin isolated from Turbinaria sp.that was collected fromKrakal (Yogyakarta) and Binuangeun (Banten) coasts. Fucoxanthin contents in each sample werecompared based on the peak areas in chromatogram after 1 mg injection of n-hexane extract ofT. decurrrens in the HPLC system. The analysis results showed that the peak areas of fucoxanthinwere significantly different among sampling locations (P = 7.99 x 10-6), sampling periods (P = 6 x10-3) and interaction of both (P = 3 x 10-3). Whereas the correlation analysis revealed that interactionbetween phosphate and temperature could be a predictor that strongly (R = 0.986) and significantlycorrelated (P = 1.09 x 10-7) with the peak areas of fucoxanthin (R2= 96.5%). These results were inline with growth limiting factor in seawater and the function of fucoxanthin as ultraviolet protector.Based on these results, it is suggested that the suitable location for fucoxanthin production is in thearea of agricultural run-off that contains an elevated concentration of dissolved phosphate
PENGARUH PEMBERIAN NATRIUM ALGINAT TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS
No full textMakalah ini melaporkan tentang pengaruh pemberian natrium alginat terhadap penurunan kadar glukosa darah tikus yang telah mengalami perusakan sel beta pankreas menggunakan aloksan. Dibuat 5 kelompok perlakuan hewan coba (tikus), masing-masing terdiri dari 5 ekor. Hewan coba dibuat mengalami kondisi hiperglikemia dengan injeksi aloksan dosis 125 mg/kg bobot badan dan kondisi hiperglikemia dicapai pada hari ke 7
ISOLASI DAN KARAKTERISASI SENYAWA GLIKOSAMINOGLIKAN DARI ORGAN IKAN PARI (Trygon sepfren)
No full textTulisan ini melaporkarq hasil penelitian tentang isolasi dan karakterisasi senyawaglikosaminoglikan dari beberapa organ ikan pari (Trygon sephen) yang mencakup proses ekstraksi melalui tahapan pencernaan, presipitasi dan pemurnian, serta identifikasi senyawa menggunakan teknik spektrofotometri inframerah, khromatografi cair kinerja tinggi dan elektroforesis
HUBUNGAN ANTARA KEBERADAAN DURI DENGAN TOKSISITAS KARANG LUNAK DAN SPONGE
No full textPenelitian yang bertujuan untuk mengetahui hubungan antara keberadaan duri dengan toksisitas ekstrak metanol karang lunak dan sponge telah dilakukan. Sebanyak 28 jenis ekstrak karang funak dan sponge diuji toksisilasnya menggunakan uji Brine Shrimp Lethality Iest (BSLT). Perbedaan mortalitas Artemia salina akibat pemberian ekstrak diuji dengan uji t dua sampel independen. Korelasi antara keberadaan duri dengan tingkat toksisitas dianalisis dengan korelasi nonparametrik Spearman
HUBUNGAN ANTARA MUSIM DENGAN KADAR CAULERPIN DALAM Caulerpa racemosa
No full textMakroalga hlau Caulerpa racemosa dipanen pada dua musim berbeda, yaitu pada musim penghujan (Mei 2003) dan pada musim kemarau (Agustus 2003
UJI AKTIVITAS ANTIOKSIDAN, TOKSISITAS, DAN SITOTOKSISITAS EKSTRAK ALGA MERAH Rhodymenia palmata
No full textRiset tentang aktivitas antioksidan, toksisitas dan sitotoksisitas ekstrak Rhodymenia palmata telah dilaksanakan. uji aktivitas antioksidan dilakukan dengan metode DppH (1,1- difenil-2-pikrilhidrazil)
PENGARUH PEMBERIAN i-KARAGINAN DAN k.KARAGINAN TERHADAP PENURUNAN KADAR GLUKOSA DARAH DAN HISTOPATOLOGI USUS KELINCI
No full textTulisan ini melaporkan tentang hasil percobaan penggunaan senyawa serat makanan, i-karaginan dan t-karaginan, untuk menurunkan kadar glukosa darah. Riset ini menerapkan metodeuji toleransi glukosa oral menggunakan kelinci sebagai hewan coba, dengan dosis pemberian 5 mL larutan 2%/kg bobot badan dan lama pemberian: t hari, 3 hari, dan 7 hari. Kontrol positif adalah klopropamida dengan dosis 4,9 mg/kg bobot badan, dan kontrol negatif adalah air suling
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