3,345 research outputs found
Genomic Insights: Disentangling Milk Yield and Reproduction Performance in First-Lactation German Holsteins
No full text501100003385 Georg-August-Universität Göttingen501100001659 DFGOpen-Access-Publikationsfonds 202
Genomic assessment of reproduction traits in Holstein dairy cattle across 3 lactations using additive genetic models and post hoc random forest analysis
No full texthttp://dx.doi.org/10.13039/501100003385 Georg-August-Universität Göttingenhttp://dx.doi.org/10.13039/501100001659 Deutsche Forschungsgemeinschaf
Georg Hermann.
No full textThe internationally renowned author of numerous novels, essays, and articles, Georg Hermann, was born as Georg Borchardt in Berlin-Friedenau on October 7, 1871, the youngest of six children in a well-established Jewish family. Later in life he used his father’s first name Hermann as his surname when writing. Contrary to the expectations for a young man from a reputable family, Hermann did not pursue the Abitur exam in a Gymnasium (secondary school), but instead received a one-year certificate in 1890, leaving school to become an apprentice salesman at a tie company. From 1896 until 1899 he worked in the Statistical Office of Berlin, at the same time attending literature and art history lectures at the University of Berlin. Afterwards he worked as a freelance writer and art critic.His first book, 'Spielkinder', was published in 1896, but he did not become well-known until 1906, with the publication of 'Jettchen Gebert', followed by its sequel, 'Henriette Jacoby'. These novels told the story of the life of a young woman living in Jewish Berlin during the Biedermeier period of the 1820s and 1830s. Politically active, Georg Hermann was also a member of the Central-Verein deutscher Staatsbürger jüdischen Glaubens.Having become known for his pacifist tendencies through his writing, and because of his Jewish heritage, Georg Hermann and his family fled to Holland shortly after the burning of the Reichstag in 1933. Although the rest of his family was saved from the Nazis after their occupation of Holland in 1943, Georg Hermann was sent to the Dutch concentration camp of Westerbork. On November 16, 1943 he was transported to Auschwitz and either died during transport or shortly after his arrival.Digital ImageRecord added to DigiTool. Aleph record suppressed. J. Palmisano 09/15/2010
A genomic assessment of the correlation between milk production traits and claw and udder health traits in Holstein dairy cattle
No full textABSTRACT: Claw diseases and mastitis represent the most important disease traits in dairy cattle with increasing incidences and a frequently mentioned connection to milk yield. Yet, many studies aimed to detect the genetic background of both trait complexes via fine-mapping of quantitative trait loci. However, little is known about genomic regions that simultaneously affect milk production and disease traits. For this purpose, several tools to detect local genetic correlations have been developed. In this study, we attempted a detailed analysis of milk production and disease traits as well as their interrelationship using a sample of 34,497 50K genotyped German Holstein cows with milk production and claw and udder disease traits records. We performed a pedigree-based quantitative genetic analysis to estimate heritabilities and genetic correlations. Additionally, we generated GWAS summary statistics, paying special attention to genomic inflation, and used these data to identify shared genomic regions, which affect various trait combinations. The heritability on the liability scale of the disease traits was low, between 0.02 for laminitis and 0.19 for interdigital hyperplasia. The heritabilities for milk production traits were higher (between 0.27 for milk energy yield and 0.48 for fat-protein ratio). Global genetic correlations indicate the shared genetic effect between milk production and disease traits on a whole genome level. Most of these estimates were not significantly different from zero, only mastitis showed a positive one to milk (0.18) and milk energy yield (0.13), as well as a negative one to fat-protein ratio (−0.07). The genomic analysis revealed significant SNPs for milk production traits that were enriched on Bos taurus autosome 5, 6, and 14. For digital dermatitis, we found significant hits, predominantly on Bos taurus autosome 5, 10, 22, and 23, whereas we did not find significantly trait-associated SNPs for the other disease traits. Our results confirm the known genetic background of disease and milk production traits. We further detected 13 regions that harbor strong concordant effects on a trait combination of milk production and disease traits. This detailed investigation of genetic correlations reveals additional knowledge about the localization of regions with shared genetic effects on these trait complexes, which in turn enables a better understanding of the underlying biological pathways and putatively the utilization for a more precise design of breeding schemes
Genetic analysis of production traits and body size measurements and their relationships with metabolic diseases in German Holstein cattle
No full textSupplemental material for the study: Genetic analysis of production traits and body size measurements and their relationships with metabolic diseases in German Holstein cattl
Evaluating the most suitable nonlinear growth model for turbot (Scophthalmus maximus) in aquaculture 2 (weight application): Multi-criteria model selection and growth prediction
No full textSeeking the most suitable model to describe the growth of turbot, we analysed
growth data of two different turbot (Scophthalmus maximus) strains reared communally in a recirculating aquaculture system. We fitted 10 different nonlinear growth models to individual weight gain data (n = 2,010) during the grow‐out phase. Analyses were carried out for each strain, for sexes within strains and for a pooled data set containing both strains and sexes. To assess the model performance, three different criteria are used. Further, a growth‐simulation was performed to evaluate the shape of the generated curve. This way we could assess the capability of the models to predict future growth. The 3‐parametric Gompertz model achieved the best fit in 42.9% of all cases tested and the lowest Bayesian information criterion in 100% of cases. The model produced realistically shaped curves and asymptotic values matching the biological attributes of the species. In contrast, 5‐parametric functions projected unrealistically shaped curves and predicted improbable mature sizes. Our results show that increasing number of parameters do not lead to increasing goodness of fit, but tend to result in overfitting, and demonstrate the advantages of the 3‐parametric Gompertz model for describing the growth of turbot
Corrigendum to “A genomic assessment of the correlation between milk production traits and claw and udder health traits in Holstein dairy cattle” (J. Dairy Sci. 106:1190–1205)
No full textDNA-based identification of novel bovine casein gene variants
No full textIn cattle, at least 39 variants of the 4 casein proteins (α(S1)-, β-, α(S2)- and κ-casein) have been described to date. Many of these variants are known to affect milk-production traits, cheese-processing properties, and the nutritive value of milk. They also provide valuable information for phylogenetic studies. So far, the majority of studies exploring the genetic variability of bovine caseins considered European taurine cattle breeds and were carried out at the protein level by electrophoretic techniques. This only allows the identification of variants that, due to amino acid exchanges, differ in their electric charge, molecular weight, or isoelectric point. In this study, the open reading frames of the casein genes CSN1S1, CSN2, CSN1S2, and CSN3 of 356 animals belonging to 14 taurine and 3 indicine cattle breeds were sequenced. With this approach, we identified 23 alleles, including 5 new DNA sequence variants, with a predicted effect on the protein sequence. The new variants were only found in indicine breeds and in one local Iranian breed, which has been phenotypically classified as a taurine breed. A multidimensional scaling approach based on available SNP chip data, however, revealed an admixture of taurine and indicine populations in this breed as well as in the local Iranian breed Golpayegani. Specific indicine casein alleles were also identified in a few European taurine breeds, indicating the introgression of indicine breeds into these populations. This study shows the existence of substantial undiscovered genetic variability of bovine casein loci, especially in indicine cattle breeds. The identification of new variants is a valuable tool for phylogenetic studies and investigations into the evolution of the milk protein genes
GWAS Hits for Bilateral Convergent Strabismus with Exophthalmos in Holstein Cattle Using Imputed Sequence Level Genotypes
Full text linkBilateral convergent strabismus with exophthalmos (BCSE) is a malformation of the eyes and is recognized as a mild but progressive disorder that affects cattle in the first two years of life. This most likely inherited disorder is rarely described in cattle resembling autosomal dominantly inherited forms of human progressive external ophthalmoplegia (PEO). In German Braunvieh cattle, two linked genome regions were found that could be responsible for the development and/or progression of BCSE. The goal of this study was to phenotypically characterize BCSE in Holstein cattle from Germany and Switzerland as well as to identify associated genome regions by GWAS. The clinicopathological phenotype of 52 BCSE-affected Holstein cattle was in accordance with the phenotype described in German Braunvieh cattle, but in addition, signs of degeneration and cellular infiltration in the eye muscles were found. By using imputed sequence level genotype data, three genome-wide significant GWAS hits were revealed on different chromosomes that were not detected by initial GWAS based on high density SNP array data highlighting the usefulness of this approach for mapping studies. The associated genome regions include the ABCC4 gene as well as markers adjacent to the NCOR2 and DNAJC3 genes all illustrating possible functional candidate genes. Our results challenge a monogenic mode of inheritance and indicate a more complex inheritance of BCSE in Holstein cattle. Furthermore, in comparison to previous results from German Braunvieh cattle, it illustrates an obvious genetic heterogeneity causing BSCE in cattle. Subsequent whole genome sequencing (WGS)-based analyses might elucidate pathogenic variants in the future
Sammlung von Merckwürdigkeiten der Natur und Alterthümern des Erdbodens, welche petrificirte Cörper enthält
No full textaufgewiesen und beschrieben von Georg Wolffgang KnorrVorlageform des Erscheinungsvermerks: Nürnberg, zu finden bey dem Author. Gedruckt bey Andreas Bieling
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