1,721,151 research outputs found
Assessment of growth factors, cytokines, and cellular markers in saliva of patients with trigeminal neuralgia
Full text linkWe proposed to perform a comparative analysis of growth factors, cytokines, and chemokine receptors on the salivary cells in the saliva obtained from trigeminal neuralgia (TN) and normal subjects. Saliva was collected from TN and healthy subjects. Salivary cells were isolated by centrifugation. The expression of the cell surface marker was analyzed by flow cytometry. A cytometric bead array was done to measure the levels of cytokines and growth factors on the flow cytometer. Saliva from TN subjects showed lower growth factor levels of Angiopoietin-2, bFGF, HGF, SCF, TGF-α, and VEGF and higher cytokine levels of IL-1β, TNF-α, CCL2, IL-17A, IL-6, and CXCL8, as well as higher expression levels of chemokine receptors CCR1 (CD191), CR3 (CD11b), CCR2 (CD192), CXCR5 (CD185), and CCR5 (CD196) in the cells from TN saliva. A certain set of cytokines and growth factors in the saliva, as well as chemokine receptors on salivary cells, could be a useful tool in the diagnostics and prognostics of trigeminal neuralgia. Trigeminal neuralgia is one of the significant pathological conditions in the class of chronic diseases around the world. Many targeted approaches are being tried by various research groups to utilize the information of the inflammatory microenvironment to resolve the pathology of chronic TN
Use of xenogenic collagen matrices in peri-implant soft tissue volume augmentation: a critical review on the current evidence and new technique presentation
Full text linkPlastic peri-implant surgical procedures aiming to increase soft tissue volume around dental implants have long been well-described. These are represented by: pedicle soft tissue grafts (rotational flap procedures and advanced flap procedures) and free soft tissue grafts (epithelialized, also called free gingival graft (FGG), and non-epithelialized, also called, connective tissue graft (CTG) or a combination of both. To bypass the drawback connected with autologous grafts harvesting, xenogenic collagen matrices (XCM)s and collagen-based matrices derived from porcine dermis (PDXCM)s have been introduced, as an alternative, in plastic peri-implant procedures. Aim: This review is aimed to evaluate and to critically analyze the available evidence on the effectiveness of XCMs and PDXCMs in soft tissue volume augmentation around dental implants. Moreover, a clinical case with a new soft tissue grafting procedure technique (Guided Soft Tissue Regeneration, GSTR) is presented. Material and Methods: An electronic search was performed on the MEDLINE database, SCOPUS, Cochrane Library and Web of Science. The electronic search provided a total of 133 articles. One hundred and twenty-eight not meeting the inclusion criteria were excluded. Seven articles of human randomized clinical trials were selected. A total number of 108 patients were treated with CTG, and 110 patients with XCM. Results: in peri-implant soft tissue augmentation procedures, XCMs seem an effective alternative to CTGs, associated with lower patient morbidity and lower operative times
Endodontic orthograde retreatments: challenges and solutions
Full text linkEndodontic orthograde retreatments are considered one of the possible treatment options in case of post-treatment diseases considering the promising results present in the literature. Despite this, a plethora of articles have been published on this topic, and drawing conclusions could be challenging. For this reason, this review aims to summarize the crucial points on each aspect of nonsurgical endodontic retreatments, discussing and comparing the current protocols, techniques, materials, and indications. Taking into consideration data from the literature, in terms of diagnosis, CBCT should be considered the first choice, since it can thoroughly affect the diagnosis and treatment plan. Regarding the procedural phases, some conclusions can be drawn: when present, coronal restoration materials such as crowns, partial prostheses, post, and core should be removed; the use of magnification devices, ultrasonic instruments, and an in-depth interpretation of radiographic images with both 2D and 3D images are strongly recommended during the orifice location; additional protocols such as irrigants activation, ultrasonic cleaning, and rotary or reciprocating instrumentation of treated canals are strongly recommended for filling materials removal and to achieve a high-quality chemo-mechanical disinfection; perforations should be treated as soon as possible, and the material of choice to treat them is the MTA or other calcium-silicate-based repair materials; the presence of ledges does not intrinsically reduce the success rate of RCRts if properly managed; in case of instrument fragments, their removal should be considered as the first treatment option, however many variables should be considered to select the proper technique or consider the option of bypassing
Inflammatory periimplant diseases and the periodontal connection question
Full text linkImplant therapy has become a widespread reality in modern dentistry. Nevertheless, dental implants can fail due to different causes, among which inflammatory peri-implant diseases (IPDs) are a major challenge, with prevalences that are much higher than previously believed. Specific searches were undertaken for each question raised between October and November 2017, in the PubMed website database (US National Library of Medicine, National Institutes of Health; Bethesda, Maryland, United States). Only articles written in English and published from 2007 onward were considered initially. The following keywords were used in the searches periimplantitis (PI), periimplant mucositis (PM), dental implant failure, periimplant microbiota, periodontal microbiota, implant failure (no temporal limit), and foreign body reaction (no temporal limit). The selection process resulted in the selection of 239 articles that were analyzed in detail in elaborating this review. The reference list was limited to the 47 most relevant articles due to editorial limits of this Journal. Intrinsic differences between natural teeth and dental implants are able to give rise to inflammatory diseases that share only minor and scarcely relevant characters, and would consequently deserve different and specifically designed instruments and strategies, for both diagnosis and therapy
Features of peri-implantitis associated with luting cement extrusion: a histopathologic report in humans
No full textOBJECTIVE: To describe and illustrate the histologic characteristics of luting cement-induced peri-implantitis in the posterior maxilla of a 56-year-old man. CASE PRESENTATION: A dental implant inserted 6 years previously in the maxillary left first premolar region revealed pus and swelling. A periapical radiograph showed severe bone loss around the dental implant, and the presence of surrounding residual particles of luting cement. The implant was removed with its adjacent tissues. The harvested implant was fixed in formaldehyde solution (formalin). A 4-mm fragment of soft tissue and a 6-mm fragment of bone were cut from the implant specimen and submitted for routine processing of hematoxylin-eosin (h&e) slides for histologic analysis. The implant specimen was processed and embedded in glycol methacrylate resin and ground to a thickness of 50 μm for histologic examination. RESULTS: The microscopic examination of the h&e slides showed connective tissue with an inflammatory infiltrate composed of histiocytes, lymphocytes, and plasma cells. There was a fragment of viable bone integrated with the bone graft material. The bone showed evidence of active resorption by osteoclasts in Howship lacunae. The implant sections showed trabecular bone with lamellar structure in the apical portion. Foreign body, compatible with luting cement, was present in the coronal portion, adjacent to the threads of the implant, as well as osteoclasts in Howship lacunae. CONCLUSION: This report, documenting a case of peri-implantitis associated with excess cement extrusion, revealed that that the bone loss was associated with an inflammatory infiltrate. Additional studies focusing on the histopathologic characteristics of peri-implantitis could help to increase the knowledge of peri-implant disease to shed light on prevention and treatment
Updates on peri-implant soft tissue stability over time, guaranteeing successful rehabilitation
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A review on the prevention of inflammatory periimplant diseases
Full text linkBackground: An impressive number of dental implants are inserted worldwide. Evolution in dental implants and simplification of surgical techniques allowed a significant increase in the number of dentists involved in implant surgery. Most of them are general dentists, are not always sufficiently formed and experienced, frequently use low-quality implants, do not adopt the proper patient selective criteria, do not adequately monitor and maintain the inserted implants, and do not report their own statistics to the dental community. Consequently, the incidence of inflammatory periimplant diseases (IPDs) has progressively increased to values significantly higher than those previously indicated by the scientific literature. Materials and Methods: Two main literature searches were undertaken in October 2018 in the PubMed Website database. Only articles written in English and published from 2008 onward were considered; 'Clinical Trial,' 'Meta analysis,' 'Observational study,' 'Review,' and 'Validation study' were selected as article type filters. The following keywords were used in the searches: 'Peri implantitis prevention' and 'Dental implant failure prevention.'Results: Preventive measures are analyzed according to the different factors that can favor the occurrence of an infection. The factors are divided into (i) implant dependent, (ii) patient dependent, and (iii) surgeon dependent. Conclusions: Scientific and clinical data confirm that when materials are selected with care, patients are carefully evaluated for factors of risk and attitude to adhere to the necessary maintenance program, and operative protocols and maintenance programs are respected dental implants can be attractive and effective tools for oral rehabilitation. Nevertheless, dentists and patients should have greater awareness that in many cases the decision to utilize dental implants cannot be taken lightly
Comparative results of single implants with and without laser-microgrooved collar placed and loaded with different protocols: a long-term (7 to 10 years) retrospective multicenter study
No full textPURPOSE: This nonrandomized, retrospective multicenter study aimed to evaluate success rates, peri-implant marginal bone loss, and clinical parameters around single implants with and without laser-microgrooved collars placed and loaded using different protocols after 7 to 10 years of function. MATERIALS AND METHODS: A chart review was used to select patients treated at five private dental clinics with single dental implants with and without laser-microgrooved collars. Cumulative success rates, peri-implant marginal bone loss, probing depth, Plaque Index, bleeding on probing, and gingival recession were recorded at baseline examinations (ie, definitive restoration delivery) and at each year during the follow-up period. RESULTS: Three hundred single implants (140 without laser-microgrooved collars and 160 with 1.7-mm laser-microgrooved collars) in 300 patients were selected. At the completion of the study period, 26 patients and 26 implants (17 with and 9 without a laser-microgrooved collar) were classified as "dropouts." Implants and restorations were categorized into two subgroups each for a total of four study groups: group 1, immediate implant placement; group 2, delayed implant placement; group 3, immediate nonocclusal loading of prostheses; and group 4, delayed loading of prostheses. Nineteen implants (6.9%) failed clinically (4 [2.7%] with and 15 [11.4%] without a laser-microgrooved collar). The difference in cumulative success rates was statistically significant (P < .05). Radiographically, at the end of the follow-up period, the laser-microgrooved group showed a mean peri-implant marginal bone loss of 0.64 mm compared with 1.82 mm for the non-laser-microgrooved group. At the same time point, a mean probing depth of 0.76 mm was observed for the laser-microgrooved group compared with 2.75 mm for the non-laser-microgrooved group. A statistically significant difference in peri-implant marginal bone loss and probing depth between the two types of implant collars was evident (P < .05). No statistically significant correlation was noted between the types of implant placement/prosthetic restoration and clinical parameters. CONCLUSION: Implants with a laser-microgrooved collar appear to influence the peri-implant soft and hard tissue stability, reducing the probing depth levels and the peri-implant marginal bone loss by more than 50% after 10 years of function, regardless of the type of implant placement and loading protocol
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