43,014 research outputs found
Carbon dioxide laser turbinate surgery for chronic obstructive rhinitis.
Riportata l'esperienza relativa al trattamento mediante laser a CO2 nella rinite ipertrofic
Hegel e le scienze sociali
Gli studi raccolti in "Hegel e le scienze sociali" propongono una reciproca correzione e integrazione tra la prospettiva filosofica hegeliana e gli snodi cruciali della teoria sociale contemporanea. Le categorie critico-dialettiche, a lungo viste dalla sociologia marxista come il guscio mistico che imprigionava il pensiero e la prassi sociale, acquistano un nuovo significato e finanche una nuova valenza metodologico-euristica.
Teoria del riconoscimento, pensiero critico-dialettico, teoria dello spirito oggettivo rivivono nell’ottica di un confronto dialogico con autori, momenti, crocevia della teorizzazione sociologica, senza quelle pretese di conclusività, integrazione sistemica e conciliazione che potevano aver illuso lo Hegel sistematico.
Saggi di A. Bellan, V. Hoesle, C. Kantner/U. Tietz, F. Neuhouser, M. Quante/D. Schweikard, P. Redding, G. Rose, A. Sartori, I. Testa
D-dimer testing in the emergency department : consensus document of ACEMC, CISMEL, SIBioC and SIMeL
D-dimer testing is currently considered a cornerstone in the diagnostic approach of patients with suspected venous thromboembolism (VTE) across different health-care settings, including the emergency department (ED). Nevertheless, inappropriate or incorrect activities developing throughout the total testing process may substantially impair the clinical usefulness of this test and delay or even challenge the fast rule out or diagnosis of VTE. The leading problem of D-dimer is represented by the poor specificity for diagnosing VTE, wherein a minority of patients with a positive D-dimer are finally diagnosed with VTE, and even more importantly, the specificity further decreases with ageing, thus contributing to increase the overcrowding in short stay units such as the ED. Due to the large heterogeneity that characterizes the use of D-dimer in the emergency room, three Italian societies of laboratory medicine (Italian Committee for Standardization of Hematology and Laboratory Methods, Italian Society of Clinical Biochemistry and Molecular Biology, and Italian Society of Laboratory Medicine), along with the Academy of Emergency Medicine and Care, have developed a consensus document about the use of D-dimer testing for diagnostics of patients with suspected VTE in this health-care setting. The evidence-based indications contained in this document will cover the leading preanalytical, analytical, and postanalytical issues that may impair the clinical efficacy of D-dimer testing in the ED
Comorbidities, alone and in combination with D-dimer, as risk factors for recurrence after a first episode of unprovoked venous thromboembolism in the extended follow-up of the PROLONG study
The PROLONG randomised clinical trial showed that an abnormal D-dimer at one month after vitamin K antagonist (VKA) suspension for a first episode of unprovoked venous thromboembolism (VTE) is associated with a higher risk of recurrence. However, other patient characteristics, such as comorbidities, in combination with D-dimer could also influence the recurrence risk. It was the objective of this study to assess the predictive value of comorbidities and D-dimer in combination for recurrence after withdrawal of VKA in patients enrolled in the PROLONG study. On the day of VKA suspension, the presence of known (coronary, peripheral,cerebral) vascular disease, chronic inflammatory bowel disease, chronic obstructive pulmonary disease, autoimmune disease, diabetes, arterial hypertension, obesity and dyslipidaemias was registered. D-dimer was measured at 30 +/- 10 days afterwards. The primary outcome was recurrent objectively documented VTE. Mean follow-up was 2.55 years. An abnormal D-dimer was observed in 44% (135/309) of patients with comorbidities and in 29% (87/299) of patients without (p=0.0003). An on-treatment analysis was conducted in 483 patients in whom VKAs were not resumed. In patients with a normal D-dimer, recurrences were observed in 14.3% (24/168) of patients with comorbidities and 10.8% (22/203) of subjects without (p=ns). In patients with an abnormal D-dimer, recurrences were observed in 24.6% (16/65) patients with comorbidities and 21.3% (10/47) of patients without (p=ns). Although abnormal D-dimer levels were significantly more frequent in patients with comorbidities, D-dimer was an independent risk factor for recurrence and the presence of comorbidities did not increase the risk of recurrence associated with an abnormal post-anticoagulation D-dimer
The testa at 250°D secretes homogalacturonans beneath the cuticle with spatial variations in methylesterification.
<p>A. Lipophilic Sudan red staining of wheat grain tissues showing the reactive cuticles: a thick cuticle (c) outside the testa (t) and a thinner cuticle outside the nucellar epidermis (ne). The staining is confined to the cuticle and does not react to structures beneath the cell wall of the testa. B. Polysaccharide staining (PATAg) of the outer layer of the testa, the cuticle and the cross cells (cc) showing a thick layer beneath the cell wall (cw) reactive to PATAg. This layer is referred as sub-cell wall layer (scw). C and D. TEM of the outer layer of the testa showing immunogold labeling with LM20 in the sub-cell wall layer, and in the cell wall between the two cell layers of the testa. Large bodies (b) and smaller vesicles (v) not labeled with LM20 are seen. E, F, G. TEM of the outer layer of the testa showing immunogold labeling with LM19 in the sub-cell wall layer, and in the large bodies and vesicles. Bars represent 20 µm in A, 2 µm in B, and 1 µm in C, D, and G (E, F are at the same scale than G).</p
Guidelines: Tutelage of professional duties or of economic interests? An accurate revision of the guidelines requires fair criticism.
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