701 research outputs found
Testa di Umberto Nordio
No full textLa scultura è stata donata all’Ateneo nel luglio del 1974 dalla vedova dell’architetto Umberto Nordio (1891-1971), che con Raffaello Fagnoni era stato il principale progettista della nuova sede universitaria. Eseguita da Ugo Carà nel 1938, l’immagine dell’architetto avrà per molto tempo una fruizione esclusivamente privata: non risulta infatti che sia stata presentata a nessuna esposizione ufficiale. Su di un piano squisitamente stilistico l’opera, pur somigliantissima, si inserisce nel recupero della tradizione ritrattistica della Roma repubblicana posta in atto alla metà degli anni trenta da artisti come Francesco Messina; in questo caso, vista la destinazione privata dell’opera, Carà stempera la severa spigolosità che caratterizza alcune realizzazioni di questo momento, che pure gli avevano regalato una certa notorietà, in favore di un “respiro dolce e sereno, talora una gracilità lirica come qualcosa di sopravvissuto che va gradatamente scomparendo […] partito da un realismo quasi brutale […] è andato eliminando il superfluo, sveltendo la tecnica e accentuando la sintesi, sino a cogliere una particolare linearità” (U. Apollonio, Ritratti di Ugo Carà, “Domus”, 146, febbraio 1940, s.n.). La testa poggia su di un alto basamento in pietra d’Aurisina disegnato appositamente da Antonio Guacci.BronzoFirmato in basso a destra “ Ugo Carà”Edificio Centrale, Rettorat
Sbiancamento professionale dei denti vitali
No full textL’incessante aumento della domanda di trattamenti cosmetici del sorriso ha imposto a molti operatori del settore odontoiatrico una presa di posizione circa le differenze tra la terapia estetica e il trattamento cosmetico dei denti anteriori. L’ultimo decennio è stato caratterizzato da una prepotente irruzione di miti e mode che hanno modificato sensibilmente il concetto di estetica del distretto testa-collo e sempre più frequentemente, fasce non trascurabili della popolazione, scelgono modelli di bellezza soggettiva molto diversi dal passato ricorrendo anche a tatuaggi, piercing, scarnificazione o impiantazione sottocutanea di corpi estranei. In questo libro gli autori, Irene Franchi, Sergio Bortolini, Ugo Consolo offrono tutte le indicazioni utili al neofita ma anche all’esperto per affrontare con estrema competenza il problema dello sbiancamento dei denti vitali. Il lettore troverà nel libro suggerimenti e risultati clinici, dati di ricerca e di lettura, un valido supporto quindi per una preparazione e un aggiornamento scientifico moderno ed efficace
Vascular endothelial growth factors in cardiovascular medicine
No full textThe discovery of vascular endothelial growth factors (VEGFs) and their receptors has considerably improved the understanding of the development and function of endothelial cells. Each member of the VEGF family appears to have a specific function: VEGF-A induces angiogenesis (i.e. growth of new blood vessels from preexisting ones), placental growth factor mediates both angiogenesis and arteriogenesis (i.e. the formation of collateral arteries from preexisting arterioles), VEGF-C and VEGF-D. act mainly as lymphangiogenic factors. The study of the biology of these endothelial growth factors has allowed a major progress in the comprehension of the genesis of the vascular system and its abnormalities observed in various pathologic conditions (atherosclerosis and coronary artery disease). The role of VEGF in the atherogenic process is still unclear, but actual evidence suggests both detrimental (development of a neoangiogenetic process within the atherosclerotic plaque) and beneficial (promotion of collateral vessel formation) effects. VEGF and other angiogenic growth factors (fibroblast growth factor), although initially promising in experimental studies and in initial phase I/II clinical trials in patients with ischemic heart disease or peripheral arterial occlusive disease, have subsequently failed to show significant therapeutic improvements in controlled clinical studies. Challenges still remain about the type or the combination of angiogenic factors to be administered, the form (protein vs. gene), the route, and the duration of administration. J Cardiovasc Med 9:1190-1221 (C) 2008 Italian Federation of Cardiology
Triterpenoids as new promising anticancer drugs
No full textTriterpenoids are structurally diverse organic compounds, characterized by a basic backbone modified in multiple ways, allowing the formation of more than 20 000 naturally occurring triterpenoid varieties. Several triterpenoids, including ursolic and oleanolic acid, betulinic acid, celastrol, pristimerin, lupeol, and avicins possess antitumor and anti-inflammatory properties. To improve antitumor activity, some synthetic triterpenoid derivatives have been synthesized, including cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic (CDDO), its methyl ester (CDDO-Me), and imidazolide (CDDO-1m) derivatives. Of these, CDDO, CDDO-Me, and betulinic acid have shown promising antitumor activities and are presently under evaluation in phase I studies. Triterpenoids are highly multifunctional and the antitumor activity of these compounds is measured by their ability to block nuclear factor-kappa B activation, induce apoptosis, inhibit signal transducer, and activate transcription and angiogenesis. Anti-Cancer Drugs 20:880-892 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
Coordinate release of angiogenic growth factors after acute myocardial infarction: evidence of a two-wave production
No full textBackground Previous studies have shown that angiopoietic growth factors, including vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2), hepatocyte growth factor (HGF) and transforming growth factor (TGF)-beta(1) are released after acute myocardial infarction (AMI). It was suggested that the release of these factors, triggered by ischemia, may be related to a reparative neoangiogenetic process. Methods Plasma VEGF, Ang-2, HGF and TGF-beta levels were measured on admission (baseline) and at various times during the acute (0-48 h) and the subacute (48-240 h) phase in 44 patients with AMI. Results In the present study, we have explored in detail the kinetics of release of these growth factors after AMI with the precise aim of evaluating the existence of a double wave of release of these factors: 0) a first wave in the acute and 00 a second one in the subacute period. The results of these analyses provided evidence for an early (peak at 24-28 h) and late (peak at approximately 170 h) increase of VEGF, Ang-2 and TGF-beta. Conclusions According to these data, we suggest that two waves of release of angiogenic factors occur after AMI. The early release makes part of an acute phase response, whereas the late release may underlie the induction of angiogenetic mechanisms involved in tissue reparation
CASE REPORT DI UN PAZIENTE SOTTOPOSTO AD INTERVENTO DI TIROPLASTICA DI TIPO I CON PROTESI DI MONTGOMERY: RILIEVI ENDOSCOPICI E FUNZIONALI
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What Language does Ugo Tudešak speak?
No full textThis work is an analysis of the two phenomena regarding the character of Ugo Tudeško in Držić’s comedy Dundo Maroje. The first part speaks about some characteristics of Italian-German »macaronics« regarding the different sources and models which the author could know while creating this character. The other part is dedicated to »the case of Ugo Tudeško« from the adaptation and direction of Dundo Maroje (Zagreb, 1938) during the time of The Independent Republic of Croatia, when the repertoire success of the time, without any explanation, disappeared at the end of 1943 from the repertoire of The Croatian national Theatre, supposedly due to the caricatural characteristics of German Ugo
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