1,720,988 research outputs found
In the Light of the Metabolic Memory Theory, Should Not All Aged People with Dysglycemia Be Treated?
No full textDysglycemia has been coined to define the prediabetic state. It defines high glucose levels below the diabetes
‘‘cut-offs.’’ The negative effects of dysglycemia, leading to cardiovascular complications, are amplified during
aging. Despite this knowledge, treatment of dysglycemia in old subjects is usually overlooked by clinical
practice. This article deals with a new theory regarding an intensive therapeutic approach targeting aged people.
This hypothesis arises from the recent theory of metabolic memory, which defines early imprinting due to
hyperglycemia in cells of the vasculature and of target organs, favoring the development of vascular complications.
In addition, metabolic memory determines a durable effect of hypoglycemic treatment that is much
longer than the period of therapy. This new evidence could allow us to hypothesize that a treatment of dysglycemia
in aged people could remodel their glucose ‘‘trajectory’’ during aging toward a more optimal one,
leading to successful aging
One- and two-compartment minimal models detect similar alterations of glucose metabolism indexes in hypertension
No full textA significant relationship between plasminogen activator inhibitor type-1 and lipoprotein(a) in non-insulin-dependent diabetes mellitus without complications
No full text
The significance of IR-HOMA index in diabetic and non-diabetic people starting a physical exercise therapy
No full textSindrome di Guyon: ovvero quando è necessaria la sinergia tra medico sportivo ed ecografista
No full text
Utilizzo dell'acido ialuronico nella terapia condrale del ginocchio: sistema monofasico e bifasico a confronto
No full text- …
