1,720,976 research outputs found
NANOASSEMBLED COMPLEXES OF NUCLEIC ACIDS, AVIDIN AND POLYMERS, USE AND PREPARATION THEREOF
No full textThe present invention discloses new nanoassembled complexes consisting of a central nucleus formed by a high-affinity interaction from nucleic acids and avidin, wherein said nucleus is stabilized in aqueous solutions, even saline, and protected from further unspecific unwanted interactions by means of suitable polymeric agents capable to mask totally or partially the nucleus itself. The nanocomplexes obtained have been shown to be stable in aqueous solutions and to have nanoparticle features. In addition, the nano-complexes have shown characteristics useful for use in biotechnological field and in nanomedicine
VEGF Embedded Sol-Gel Derived Silica Polymers as Supports for the Neovascularization of Bioengineered Implants
No full textsol-gel derived silica gels for the controlled release of drugs: influence of synthesis and processing conditions in the release
No full textThe influence of processing parameters and synthetic strategies in the properties of sol-gel derived silica matrices intended for the release of bioactive compounds was investigated. The time-evolution of the matrix properties during its aging at room temperature in the dry and wet forms was investigated by measuring some of its physical and drug retaining properties. The results indicate that long term gel aging in the wet form is fundamental for the obtainment of dry matrices that are stable upon storage, a fundamental requirement for any practical application. In the case of hybrid matrices obtained by replacing part of the tetraethoxysilane precursor with mono-methyl trimethoxysilane, the order of addition of the reaction component is also important in determining the properties of the final dry gel, probably by influencing the polymer structural properties. This parameter acts synergistically with the matrix composition in determining the release properties of xerogels embedded with bioactive compounds
Stabilization of silica xerogels intended for the sustained release of drugs by means of catalysts
No full textPolimeri inorganici a base di silice sol-gel nel rilascio controllato di molecole bioattive di diversa natura:economicità , biocompatibilità e versatilità
No full textBisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds.
No full textCalcium-modulated release of active platinum antitumor compounds from sol-gel silica xerogels.
No full textSynthesis, characterization, cytotoxicity, and release from silica xerogels of a platinum(II) complex to be used for the local treatment of bone tumors or metastases.
No full textWet sol-gel derived silica for controlled release of proteins.
No full textThe potential of wet sol-gel derived silica gels as new matrices for the entrapment and sustained release of proteins was investigated. Model proteins, BSA, ribonuclease-A and avidin, with differing molecular weights and/or isoelectric points, were entrapped in two silica polymer formulations having different silica contents (4% and 12% wt/v). The conformational stability of the proteins after entrapment and their release after immersion into physiological conditions were measured. Circular dichroism analysis showed that protein conformation is maintained after entrapment and stability is enhanced. Protein-free formulations were injected intramuscularly into BALB/c mice to monitor the in vivo fate of the matrix, and the results showed that the gel is totally reabsorbed, without any apparent surrounding inflammation process. The time required for matrix bioerosion varied between one to three weeks, depending on its SiO(2) content. Erosion was also measured in vitro and the contribution of erosion and diffusion to the release of the embedded proteins was quantified. These data indicate that wet silica polymers obtained by the sol-gel route are promising matrices for the sustained release of protein drugs
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