106,420 research outputs found
Teo T. Antonio: Tulambuhay
No full textNilalaman ng disertasyong ito ang topograpiya at landas na tinahak ng pagsulat ng biyograpiya ng isang makatang maituturing na muhon ng kasaysayang pampanitikan sa bansa, si Teo T. Antonio. Bukod sa mismong Tulambuhay, binigyang diin ang dahilan kung bakit dapat pasimulan ang proyektong Popular Biography kung bakit dapat pang sumulat ng biyograpiya sa malawak na pagtanaw sa mundo ng panitikan at pagsulat ang paraan kung paano lalandasin ang biyograpiya bilang babasahing popular at pampanitikan at ang mungkahing proseso sa pagsulat at pakikipagniig sa proyekto ng mananaliksik.
Inilalahad ng mananaliksik ang paglalapat ng iniakmang metodolohiya o pamamaraang ipinapanukala nina Edel Leon (1973) sa larang ng Literary Biography—bagamat binigyan ng pag-akma ng mananaliksik upang lumapat sa kontekstong Filipino, at Bienvenido Lumbera (1997) sa konteksto naman ng lokal na pagsulat ng biyograpiyang pampanitikang may tuon sa pag-humanize sa paksa, o mas tiyak: mas malalim na pagkilala sa iba’t ibang pwersang sikolohikal at panlipunan na pinaglulunsaran ng manlilikha. Buhay ng manlilikhang hindi dapat ipagkait sa pamayanang akademiya, sa mga karaniwang mambabasa, at tumatangkilik sa panitikan sa ating bansa sa kabuuan tungo sa malapit na hinaharap
T-cell assays for the investigation of drug hypersensitivity
No full textAttribution of drug culpability in delayed drug reactions can be challenging, particularly when multiple medications are involved. Various in vitro T-cell tests have been utilized in research settings as part of diagnostic algorithms and have the potential to provide a safe method of testing without provoking hazardous reactions. Routine testing is currently limited by variable sensitivity. However, improved understanding of the underlying mechanisms and assay optimization in larger cohorts aligned to the drug and reaction phenotype will further improve the role of T-cell assays as a reliable means of determining the causative drug. Sensitivity and specificity of the lymphocyte proliferation assay (LTT), ELISpot, and ELISA are determined by drug and phenotype factors, and a detailed understanding of the laboratory process is required to ensure the test results are interpreted correctly for clinical use in the diagnosis of T-cell-mediated drug hypersensitivity reactions.</p
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Recursive parameter estimation for time-varying systems in presence of unknown but bounded measurement noise.
No full textLetter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
MVMD-MOMEDA-TEO Model and Its Application in Feature Extraction for Rolling Bearings
No full textIn order to extract fault features of rolling bearings to characterize their operation state effectively, an improved method, based on modified variational mode decomposition (MVMD) and multipoint optimal minimum entropy deconvolution adjusted (MOMEDA), is proposed. Firstly, the MVMD method is introduced to decompose the vibration signal into intrinsic mode functions (IMFs), and then calculate the energy ratio of each IMF component. The IMF component is selected as the effective component from high energy ratio to low in turn until the total energy proportion Esum(t) ≥ 90%. The IMF effective components are reconstructed to obtain the subsequent analysis signal x_new(t). Secondly, the MOMEDA method is introduced to analyze x_new(t), extract the fault period impulse component x_cov(t), which is submerged by noise, and demodulate the signal x_cov(t) by Teager energy operator demodulation (TEO) to calculate Teager energy spectrum. Thirdly, matching the dominant frequency in the spectrum with the fault characteristic frequency of rolling bearings, the fault feature extraction of rolling bearings are completed. Finally, the experiments have compared MVMD-MOEDA-TEO with MVMD-TEO and MOMEDA-TEO based on two different data sets to verify the superiority of the proposed method. The experimental results show that MVMD-MOMEDA-TEO method has better performance than the other two methods, and provides a new solution for condition monitoring and fault diagnosis of rolling bearings
Investigation of the system Al₂O₃-TeO₂-O₂
No full textThe system Al₂O₃-TeO₂-O₂ has been investigated by X-ray diffraction and differential thermal analysis in air and in sealed silica ampoules. The tellurate, Al₂TeO₆, with tellurium in the +6 valence state, forms in air but not in vacuum at 1 mm pressure. A second phase, a tellurite, possibly Al₂Te₂O₇, forms in air or vacuum by devitrification. The glass-forming region is wider than previously stated and is more extensive in vacuum--from 50% to 98% TeO₂. Tentative phase boundaries have been placed for the system in air and vacuum --Abstract, page ii
A case for using structural equation modelling (SEM) in educational technology research
No full textStructural equation modelling (SEM) enjoyed a renaissance in the early 1970s. Many believed this was because of the advancement of SEM software, which made SEM readily accessible to substantive researchers, for them to address a variety of research questions. Some examples of such software include LISREL (LInear Structural RELations) by Jöreskog and Sorbom (2003), EQS (Bentler, 2003) and AMOS (Analysis of Moment Structures) by Arbuckle (2006). The combination of methodological advances and improved interfaces in these SEM software packages has resulted in the diverse usage of SEM. For example, Hershberger (2003) examined major journals in psychology from 1994 to 2001 and found that over 60% of these journals contained articles using SEM, more than double the number of articles published from 1985 to 1994. In the field of educational technology, SEM has been employed to study technology acceptance (Teo, 2009), attitude towards computer use (Teo, 2008), development and validation of scales (Teo & Noyes, 2008), and use of the Internet (Chiu, Sun, Sun & Ju, 2007)
Contributions of the Monkey Inferior Temporal Areas TE and TEO to Visual Categorization
No full text\ua9 2021 Published by Oxford University Press 2021. The ability to categorize images is thought to depend on neural processing within the ventral visual stream. Recently, we reported that after removal of architectonic area TE, the terminal region of the ventral stream, monkeys were still able to categorize images as cats or dogs moderately well. Here, we investigate the contribution of TEO, the architectonically defined region located one step earlier than area TE in the ventral stream. Bilateral removal of TEO caused only a mild impairment in categorization. However, combined TE + TEO removal was followed by a severe, long-lasting impairment in categorization. All of the monkeys tested, including those with combined TE + TEO removals, had normal low-level visual functions, such as visual acuity. These results support the conclusion that categorization based on visual similarity is processed in parallel in TE and TEO
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