1,721,012 research outputs found
Butrylcholinesterase Activity in Chronic Liver Disease Patients and Correlation with Child-Pugh Classification and MELD Scoring System
No full textWOS: 000353008800027PubMed ID: 25975011Background: After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more accurate systems for determination of prognosis in patients with acute liver failure - cirrhosis and prioritization for receipt of a liver transplant - prediction of post transplant mortality. Butrylcholinesterase is an enzyme which is synthesized in the liver. The aim of the study was to evaluate the clinical utility of butrylcholinesterase as a discriminatory and prognostic factor in chronic liver disease patients. Methods: Intergroup diversity for butrylcholinesterase activity was investigated in sixty cirrhotic, 20 chronic hepatitis patients, and 20 healthy subjects. Correlations between butrylcholinesterase activity and Child-Pugh classification and MELD scoring systems were examined. Results: In addition to the statistically significant decrease in butrylcholinesterase activity among Child-Pugh A/B/C stages, the decrease in butrylcholinesterase activity was also statistically significant in control vs. Child-Pugh stage A and chronic hepatitis vs. Child Pugh stage A groups. A statistically significant correlation was determined between butrylcholinesterase activity and Child Pugh/MELD scores. Conclusions: Serum butrylcholinesterase activity might be helpful for discrimination of chronic hepatitis from cirrhosis after determination of reliable cut-off levels and dependent on the reductions of serum levels in acute liver failure and cirrhosis. It might be a useful tool for prioritization of liver transplantation
Effects of combination of p-dimethylaminoazobenzene and dioxin on serum lipid profile
No full textObjective: The liver cancer initiator p-dimethylaminoazobenzene and the potent liver promoter Dioxin are the environmental pollutants that people may be exposed to those in their daily lives. Butyrylcholinesterase is a natural detoxificant that hydrolyses some xenobiotics. The relation between butyrylcholinesterase activity and lipoprotein metabolism is well documented. In this study, we aimed to determine the effects of two chemicals that had potential of liver cancer by combined administration on butyrylchonlinesterase activity and serum lipid profile. Material and Methods: p- dimethylaminoazobenzene was administered with diet as 0.06% ratio for 15 weeks and dioxin was administered weekly as 70 ng/100 g body weight for 13 weeks. At the end of the study serum LDL Cholesterol, HDL Cholesterol, Triglyceride, and Total Cholesterol levels and Butyrylcholinesterase, Lecithin: Cholesterol Acyltransferase activities were measured. Results: Butyrylcholinesterase activity was increased (p< 0.01) while LDL Cholesterol (p< 0.001), HDL Cholesterol (p< 0.01) and Total Cholesterol (p< 0.01) levels were decreased significantly in p-dimethylaminoazobenzene and dioxin treated rats. There was no change in Lecithin: Cholesterol Acyltransferase activity. Conclusion: Carcinogens with lipophilic properties increases Butyrylcholinesterase activity when administered with p-dimethylaminoazobenzene and dioxin, and interacts with lipoproteins and causes lipid protein metabolism impairments. Copyright © 2010 by Türkiye Klinikleri
Evaluation of cardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats using serum biochemical parameters
No full textWOS: 000250273700315
Biological activity evaluation of new 3,5,6-trisubstituted triazine derivatives bearing different heterocyclic rings against lung cancer cell lines
No full text41st FEBS Congress on Molecular and Systems Biology for a Better Life -- SEP 03-08, 2016 -- Kusadasi, TURKEYWOS: 000383616901094…FEB
Apoptosis inducing effects of novel benzimidazole derivatives bearing pyridyl/pyrimidinyl piperazine moieties on A549 lung adenocarcinoma
No full text41st FEBS Congress on Molecular and Systems Biology for a Better Life -- SEP 03-08, 2016 -- Kusadasi, TURKEYWOS: 000383616901091…FEB
Novel morpholine dithiocarbamate derivatives induces apoptosis in C6 glioma
No full text41st FEBS Congress on Molecular and Systems Biology for a Better Life -- SEP 03-08, 2016 -- Kusadasi, TURKEYWOS: 000383616901097…FEB
In vitro biological and toxicological evaluation of Lathyrus sp extracts
No full text63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- AUG 23-27, 2015 -- Budapest, HUNGARYWOS: 000367558100286
Oxidative stress-mediated myrocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats
No full textWOS: 000268575400009PubMed ID: 19538020In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malondialdehyde and nitric oxide levels were measured. All measured parameters were found elevated in the drug-treated rats, being the highest in the 50-mg/kg ofloxacin-treated rats. Ciprofloxacin and ofloxacin may cause myocardiotoxicity by inducing the oxidative stress in the heart, and nitric oxide is partly responsible for this toxicity
EFFECTS of Aspirin Overdose ON BalfVEGF of Endotoxemic Rats
No full text9th International Meeting of the International-Society-for-the-Study-of-Xenobiotics(ISSX) -- SEP 04-08, 2010 -- Istanbul, TURKEYWOS: 000281147700268…Int Soc Study Xenobio
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na+/K+ ATPase activity and lipid profile
No full textPubMed: 25572761Objectives: Diabetes mellitus (DM) is a chronic disease and one of the most important health problems. Several factors may be responsible for the complications of diabetes mellitus including alterations in the activities of sodium-potassium adenosine triphosphatase (Na+/K+ ATPase) and lecithin:cholesterol acyltransferase (LCAT) and also levels of nitric oxide (NO). We have investigated the effects of alterations in serum NO levels on activities of erythrocyte membran Na/K ATPase and serum LCAT enzymes. Materials and methods: The experiments were performed on male rats divided into four groups: group 1, control (standart diet); group 2, diabetic control (single dose of 65 mg/kg of streptozotocin (STZ), i.p); group 3, STZ + insulin (8 IU/kg/day s.c.); group 4 (STZ + l-NAME 5 mg/kg/day orally). Result: Streptozotocin-induced diabetic rats, showed a significant increase in blood glucose and serum cholesterol (C) and triglyceride (TG). Compared to the control group with diabetic group plasma LCAT concentrations and erythrocyte membrane Na +/K+ ATPase were found to be decreased. Activities of Na+/K+ ATPase and serum NO level were decreased with the administration of l-NAME. We observed that insulin was ameliorated in all parameters. Conclusions: Serum NO levels is related to erythrocyte membrane Na+/K+ ATPase activity. But serum NO levels did not affect the plasma LCAT activity and serum lipid profile
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