5,783 research outputs found
He Would Tell You
No full textHe Would Tell You Here in the secret chambers Of my darkest heart are things I will never tell: Here is oily blood and brittle bone Here are clotted lips, frothy lungs Decomposed and muted tongues Here twisted cloth lays strangely stiff In a powdery triptych pit Where a dumbstruck man and wife Lock quick lime arms round their Dream face child, here Past the grave yards fragrant stones Memory’s nightmare head will not lay prone Its battlefields etched on a red brocade Inlaid with a crown of s..
Description of author Lisa Price\u27s hiking trip through the Hundred Mile Wilderne
No full textDescription of author Lisa Price\u27s hiking trip through the Hundred Mile Wilderness, the final section of the Appalachian Trail in Maine. Price, who has hiked the Appalachian Trail for four years, one section at a time, meets up with fellow hikers Noel and Caroline at Shaw\u27s Boarding House in Monson, and the three reach the summit of Mount Katahdin together
An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer
No full textProfessor Alfredo Falcone and Dr Lisa Salvatore speak to Roshaine Gunawardana, Managing Commissioning Editor: Professor Alfredo Falcone is the Director of the Department of Oncology and the Specialization School at the University Hospital of Pisa, Italy. He trained in Pisa and Genoa, Italy, and has held major positions in Italian oncology since 2000. He currently has more than 300 publications, including papers in peer-reviewed international and national journals, book chapters, and more than 600 abstracts of presentations to international and national conferences. The majority of his papers regard clinical and translational research, with a particular focus on metastatic colorectal cancer. Dr Lisa Salvatore is a medical oncologist in the Department of Translational Research and New Technologies in Medicine and Surgery at the University of Pisa. She has been an author on about 40 publications in major peer-reviewed publications and has made numerous presentations in national and international conferences. Her main interest is focused on clinical and translational research in metastatic colorectal cancer
Recommended from our members
Q & A with Lisa Duggan
No full textLisa Duggan is a Professor in American Studies at New York University. She was chair of this year's plenary session, which was entitled “Lesbian, Counter, and Queer: New Directions in the Study of Femininity.” She is author of Sapphic Slashers: Sex, Violence, and American Modernity, which won the John Boswell Prize of the American Historical Association in 2001. Her new book, The End of Marriage: The War over the Future of State Sponsored Love, will be published by University of California Press
RHM Author Interview: Dr. Lisa Melonçon, RHM Editor, Interviews Dr. Abby Dubisar and Sara Davis on Their Persuasion Brief, "Communicating Elective Sterilization: A Feminist Perspective"
No full textRHM Author Interview: Dr. Lisa Meloncon, RHM Editor, interviews Dr. Abby Dubisar and Sara Davis on Their Persuasion Brief, “Communicating Elective Sterilization: A Feminist Perspective.
Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins
No full textNucleophosmin (NPM1) is a multifunctional protein that controls cell growth and genome stability via a mechanism that involves nucleolar-cytoplasmic shuttling. It is clear that NPM1 also contributes to the DNA damage response, yet its exact function is po
ROLE OF POST-TRANSLATIONAL MODIFICATIONS IN MODULATING APE1 FUNCTIONS IN TUMOUR CELLS
No full textApurinic/apyrimidinic endonuclease 1 (APE1) is the main mammalian endonuclease involved in the repair of DNA lesions caused predominantly by oxidative and alkylating stresses through its participation in base excision repair (BER) pathway. Although APE1 was discovered for its ability to cleave and remove AP-sites and to enhance the DNA binding properties of several cancer-related transcription factors, through redox-dependent mechanisms (involving its so-called Ref-1 activity), in the latest years investigators have described new and broader functions for this DNA repair enzyme. In fact, it has been demonstrated a direct role for APE1 in the regulation of gene transcription and an unexpected role in the RNA metabolism being able to cleave damaged or site-specific RNAs. Despite different works regarding the transcriptional and post-translational mechanisms that cells used to control and to redirect APE1 to its several functions, it is still a matter of debate the role of the first 33 amino acids, a unique evolutionary N-terminus specific for the mammalian protein, that impacts, through macromolecules interaction and post-translational modifications, on controlling APE1 activities. In this work of Thesis, new acetylated lysine residues were identified in vivo and the role of acetylation sites at N-terminus (Lys 27-35) in regulating APE1 functions and subcellular localization were studied. Moreover, seventeen new interacting partners were identified. Among these, the attention was focused on APE1 and Nucleophosmin 1 (NPM1) interaction within nucleoli and nucleoplasm. NPM1 is a nucleolar protein, mainly involved in ribosome biogenesis, stress responses and genome maintenance. Growing body of evidences emphasizes a role for NPM1 in DNA repair field, but its exact role(s) has not been identified yet. Interestedly, patients with acute myeloid leukemias (AMLs), characterized by the expression of a mutated form of NPM1 (NPM1c+), causative for its aberrant cytoplasmic localization, represent better responders to chemotherapy and for favorable overall survival. At present, the molecular reasons underneath the role for NPM1 in tumorigenesis of solid tumors and in AMLs are still lacking. In this framework, a clear contribution of NPM1 in DNA repair control, through the functional regulation of the APE1 endonuclease activity in BER pathway, its subcellular localization and stability has been demonstrated in vivo. In this light, the positive clinical impact of NPM1c+ in chemotherapeutic response might be related to the potential interference with the functions of NPM1 interacting partners, once delocalized in the cytoplasm. An intriguing mechanism for explaining also the biological effects of APE1 genetic variants, considered in this work of Thesis, supported by the observation that the majority of the polymorphisms presents an altered complex network of interactions, protein stability and stress response, affecting the APE1 functional status.
Our findings provide a glimpse into the role of the nucleolus and NPM1 in controlling APE1 functions, suggesting a critical role for the intricate network of APE1 interacting partners, especially NPM1, and post-translational modifications in BER in vivo that might be important for explaining the APE1 dysregulation seen in different types of tumors
Preservation assessment of the collections at the Oregon State Library, Salem, Oregon: October 6, 7 & 8, 2009
No full textReport -- Appendix A. Documentation Images -- Appendix B. Resources -- Appendix C. Recommended Books, Collection Policy Resources, Organizations for Reference & Vendors for Supplies -- Appendix D. Cost Estimates.prepared by Lisa Duncan, Art Conservator, LLC.Title from PDF title page (viewed on February 8, 2023).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
State formation and underdevelopment in the Arab world
No full text[No abstract available]Amin G, 1981, AL MASHRIQ AL ARABI; Anderson Lisa, 1986, STATE SOCIAL TRANSFO; Batniji R, 2014, LANCET, V383, P343, DOI 10.1016-S0140-6736(13)62185-6; Beinin J., 2001, WORKERS PEASANTS MOD; Bromley S, 1994, RETHINKING MIDDLE E; Carl Brown L., 1984, INT POLITICS MIDDLE; Dewachi O, 2014, LANCET, V383, P449, DOI 10.1016-S0140-6736(13)62299-0; Fieldhouse David Kenneth, 2006, W IMPERIALISM MIDDLE; Gelvin J, 2007, ISRAEL PALESTINE CON; Gelvin J, 2012, ARAB UPRISING WHAT E; Gerber H., 1987, SOCIAL ORIGINS MODER; Hanieh A, 2011, CAPITALISM AND CLASS IN THE GULF ARAB STATES, P1, DOI 10.1057-9780230119604; Hinnebusch Raymond, 2010, MIDDLE E CRITIQUE, V19, P201; Issawi C., 1982, EC HIST MIDDLE E N A; Kerr Malcolm H., 1971, ARAB COLD WAR GAMAL; Owen R, 1985, ARAB SOC CONTINUITY, P16; Owen Roger, 1998, HIST MIDDLE E EC 20; Richards A., 2008, POLITICAL EC MIDDLE; Rivlin P, 2011, ARAB EC 21 CENTURY; Rogan E, 2010, ARABS; Schatkowski-Schilcher L, 1992, PROBLEMS MODERN MIDD, P229; Seddon D, 1994, FREE MARKETS FOOD RI; Thompson E, COLONIAL CITIZENS RE; WATERBURY J, 1991, INT J MIDDLE E STUD, V23, P12
- …
