127 research outputs found
Kistik Fibrozisli Bebeklerde Fidgety Hareketlerin Analizi
No full textGeneral Movements (GMs) occur as fidgety movements (FMs) between postterm 9 and 20 weeks. It may indicate some neurodevelopmental problems when FMs are absent or abnormal at the required periods. The aim of this study was to evaluate FMs and motor repertoire in infants with cystic fibrosis (CF). Eighteen infants with CF and twenty healthy infants with the age of postterm 3-5 months old were included in the study. Demographic and clinical data of infants were recorded. 5-min videos of infants were recorded to analyze FMs and motor repertoire. FMs were analyzed with observational GMs assessment based on Prechtl method and motor optimality score (MOS) was obtained for each infant. This study was recorded in the Clinical Trials database with NCT03381157 registration number. There were significant differences between CF and healthy infants’ total MOS and it’s FMs subcategory (p<0.05). There was a significant negative correlation between the duration of hospitalization and total MOS in infants with CF (r=-0.378, p=0.036). There was also a significant positive correlation between vitamin A level and total MOS in infants with CF (r=0.665, p=0.026). Based on our results; problems such as increased hospitalization rate, recurrent infections, respiratory and digestive system effects may adversely affect motor repertoire in infants with CF. Therefore, it is recommended that infants with CF should be supported in early developmental physiotherapy in addition to the pulmonary rehabilitation within the rehabilitation programmes.ONAY SAYFASI iii
YAYIMLAMA VE FİKRİ MÜLKİYET HAKLARI BEYANI iv
ETİK BEYAN v
TEŞEKKÜR vi
ÖZET vii
ABSTRACT vii
İÇİNDEKİLER ix
SİMGELER VE KISALTMALAR xi
ŞEKİLLER xiii
TABLOLAR xiv
1. GİRİŞ 1
2. GENEL BİLGİLER 3
2.1. Kistik Fibrozis 3
2.2. Prevelans ve İnsidans 3
2.3. Genetik 4
2.4. Kistik Fibrozis Patofizyolojisi 4
2.5. Kistik Fibroziste Tanı 5
2.5.1. Tanı Testleri 5
2.5.2. Yenidoğan Tarama Programı 6
2.6. Tedavi 9
2.7. Akciğer Problemi Olan Bebeklerde Gelişim 10
2.8. General Movements 12
2.8.1. Preterm General Movements 13
2.8.2. Writhing General Movements 13
2.8.3. Fidgety Hareketler 14
2.8.4. Fidgety Hareketlerin Kliniksel Anlamları 17
3. GEREÇ VE YÖNTEM 19
3.1. Bireyler 19
3.2. Yöntem 20
3.2.1. General Movements Değerlendirmesi 23
3.3. İstatistiksel Analiz 25
4. BULGULAR 26
4.1. Bebeklerin Demografik, Klinik, Prenatal ve Laboratuvar Özellikleri 26
4.2. Kistik Fibrozisli Bebeklerin Tedavilerine İlişkin Bilgiler 31
4.3. Bebeklerin Motor Repertuar Değerlendirmesi 31
4.4. Kistik Fibrozisli Bebeklerde E Vitamini ve A Vitamini Düzeyi ile Total Motor Optimalite Skoru Arasındaki İlişki 33
4.5. Kistik Fibrozisli Bebeklerde Terde Klor ve Kondüktüvite Düzeyi ile Total Motor Optimalite Skoru Arasındaki İlişki 33
4.6. Kistik Fibrozisli Bebeklerde Hastaneye Yatış Süresi ile Total Motor Optimalite Skoru Arasındaki İlişki 33
5. TARTIŞMA 34
6. SONUÇ VE ÖNERİLER 44
7. KAYNAKLAR 45
8. EKLER
EK-1: Tez Çalışması İle İlgili Etik Kurul İzinleri
EK-2: Aydınlatımış Onam Formları
EK-3: Motor Repertuar Değerlendirmesi
EK-4: Orjinallik Ekran Çıktısı
EK-5: Dijital Makbuz
9. ÖZGEÇMİŞGeneral movements (GMs), post-term 9-20 hafta arasında fidgety hareketler (FMs) olarak ortaya çıkmaktadır. FMs’nin görülmesi gereken dönemlerde hiç görülmemesi veya anormal olması bazı nörogelişimsel bozukluklara işaret edebilmektedir. Bu çalışmanın amacı, kistik fibrozisli (KF) bebeklerde FMs’leri ve motor repertuarı değerlendirmekti. Çalışmaya postterm 3-5 aylık 18 KF’li bebek ve postterm 3-5 aylık 20 sağlıklı bebek dahil edildi. Bebeklerin demografik ve klinik özellikleri kaydedildi. KF’li ve sağlıklı bebeklerin FMs’leri 5 dakikalık video kayıt yöntemi ile kaydedildi. Gözlemsel GMs değerlendirmesi kapsamında Prechtl Yöntemi ile FMs’ler analiz edildi. Her bebeğin total motor optimalite skoru (MOS) hesaplandı. Bu çalışma NCT03381157 numarası ile Clinical Trials veritabanına kaydedildi. KF’li ve sağlıklı bebeklerin total MOS ve Fidgety hareketler alt kategorisi arasında anlamlı fark vardı (p<0,05). KF’li bebeklerde hastanede yatış süresi ile total MOS arasında negatif ve düşük-orta düzeyde istatistiksel olarak anlamlı bir ilişki bulundu (r=0,378, p=0,036). Ayrıca A vitamini düzeyi, total MOS ile pozitif ve iyi derece anlamlı bir ilişki gösterdi (r=0,665, p=0,026). Çalışmamızın sonuçlarına göre; KF’li bebeklerde artan hastaneye yatış, tekrarlayan enfeksiyonlar, solunum ve sindirim sistemini etkilenimi gibi problemler, fidgety hareketleri ve motor repertuarı olumsuz yönde etkileyebilir. Bu nedenle rehabilitasyon uygulamaları kapsamında; pulmoner rehabilitasyona ek olarak KF’li bebeklerin gelişimsel fizyoterapi açısından da desteklenmesi önerilmektedir
Author Correction: Multiperiod Multi Traveling Salesmen Problem Considering Time Window Constraints with an Application to a Real World Case
No full textWOS: 000473179100002
Lift coefficient calculation using a geometric/solution adaptive Navier Stokes solver on two-dimensional cartesian grids for compressible and turbulent flows
No full textIn this study, two-dimensional geometric and solution adaptive refinement/coarsening scheme codes are generated by the use of Cartesian grid generation techniques. In the solution of compressible, turbulent flows one-equation Spalart-Allmaras turbulence model is implemented. The performance of the flow solver is tested on the case of high Reynolds number, steady flow around NACA 0012 airfoil. The lift coefficient solution for the airfoil at a real-life-flight Reynolds number is compared with the experimental study in literature
Factors affecting the performance of the deep cervical flexors in young people using smartphones
No full textObjective To determine the factors affecting the performance of the deep cervical flexors (DCFs) in young people using smartphones. Methods Eighty-six individuals were enrolled in this study. Joint position sense errors, forward head and protracted shoulder posture, DCFs, and the superficial cervical muscles were evaluated. Smartphone Addiction Scale, State-Trait Anxiety Inventory, and International Physical Activity Questionnaire were used. Results Regression analysis indicated that smartphone addiction and superficial cervical muscle strengths affect the performance of DCFs independently (p < 0.05). SAS was correlated with JPSE-flexion (r = 0.408), DCF activity/performance score (r = -0.453/r = -0.431), forward head posture (r = -0.412), and cervical flexor/extensor muscle strengths (r = -0.313/r = -0.319). Conclusion Smartphone addiction and cervical superficial muscles are related to the performance of the DCFs in young people. Using smartphones causes impaired joint position sense in flexion, decreased DCF activity, and forward head posture
Assessment of motor repertoire and neurodevelopmental level in infants with cystic fibrosis: a follow-up study
No full textProfit Bel Haritası Anketi Türkçe versiyonunun geçerlik güvenirlik ve kültürler arası uyarlaması
No full textMeasuring the possibilities of interfuel substitution
No full textWhat are the costs of making consumption of production activities use less-polluting fuels? The author reviews how the fuel mix used by different industries has changed over time and examines 2 techniques for estimating the responsiveness of fuel demand to fuel prices: econometric models and the engineering approach. With econometric models, the elasticity of substitution between energy and other inputs determines the costs of making activities less energy-intensive, while the elasticity of substitution between sources of energy (interfuel substitutability) determines the marginal costs of replacing one energy source with another. The engineering approach uses more detailed technical information and can draw a more complete picture, but with less ability to inform about activities with a vast number of different economic agents. Among the author's main conclusions: There are surprisingly large variations in energy and fuel use over time and between countries. Industrial output increased 62 percent in OECD countries between 1971 and 1988, for example, while energy use stayed unchanged. Also, shares of energy sources for industry and electricity vary greatly with local availablity, indicating that these sectors have some flexibility in choice of energy source. A judgment on whether this variability indicates that an economy responds cheaply if energy prices are changed selectively depends on how one reads the more detailed studies in the econometric and engineering literature. Lack of data is the biggest problem in estimating fuel and energy substitutability in non-OECD countries. Engineering studies of fuel switching in industry are rarely available. They exist, however, for the power industry and could be used to estimate the costs of alternative fuel-mixes for particular greenfield sites. The technique could not be used for assessment of economywide policies. Econometric studies are useful inasmuch as they take a sector- or economywide perspective. Econometric techniques are challenging, but often represent the state of the art in providing reliable estimates for elasticies of substitution - particularly when data are scarce and the level of aggregation is high. The issue of whether econometrically estimated structural parameters can be transferred across borders has not been thoroughly investigated.Oil Refining&Gas Industry,Transport and Environment,Energy and Poverty Alleviation,Energy and Environment,Airports and Air Services
Multiperiod Multi Traveling Salesmen Problem Considering Time Window Constraints with an Application to a Real World Case
No full textWOS: 000473179100001This study arises from a real world problem. In the problem, a number of university representatives are required to visit a number of exam locations departing from a central location and returning back to the same location. Each location may be visited in one of four different periods; however these visits must be done in pre-specified time windows. Time windows may be different from location to location and across periods for the same location. The problem is modeled as a multi-period multi traveling salesmen problem with time window constraints. Earlier attempts to solve the resulting models using mixed integer linear programming approach proved to be ineffective. Hence two stochastic heuristic search techniques, based on simulated annealing (SA) and robust tabu search (RTS), are used. For this, a new solution representation and associated decoding and encoding mechanisms are developed. Proposed approaches are tested on various problem instances, and performance of the solution approaches are discussed. Finally, a real case is considered for which a method for obtaining travel distance and travel time matrices from Google Distance Matrix API is developed. The results obtained from the real case is also discussed and future research directions are provided.Anadolu University Scientific Research Projects Commission [1506F495]This study was supported by Anadolu University Scientific Research Projects Commission under the grant no: 1506F495. The author would like to thank the anonymous reviewers and the Editor-in-Chief for their helpful and constructive comments that greatly contributed to improving the final version of the paper
Nazlı Eray öykücülüğünde rüya
No full textTürk öykücülüğünde fantezi yazarlığının önemli isimlerinden biri olan Nazlı Eray (d. 1945), yazın yaşamına girdiği 1960’lı yıllardan bugüne kadar çizgisinden şaşmadan edebî üretimini fanteziler üzerine kurmuştur. Eray’ın, ilk yapıtları ile edebiyat çevrelerince Sait Faik çizgisine yakın bulunur. Bunun sebebi, öykülerinde yer alan dışlanmış, itilmiş, sıradan insanları duyarlılıkla işlemesidir. Öykülerinde bu insanlara ve yaşantılarına sevgiyle yaklaşan yazar, hem kendi hem de dışlanmış insanların özlemlerini ve yaşamdan beklentilerini kurduğu fantezilerle gerçekleştirir. Eray’ın fantezist yazım tarzını besleyen önemli damarlardan biri de rüyalardır. Kurgusal anlamda da olsa yazarın öykü yaratımında önemli işlevlerle yüklü olan rüya, metnin psikanalitik edebiyat kuramı çerçevesinde değerlendirilmesine olanak tanır. Gerçek ile düşü bir arada kullanarak farklı bir gerçeklik katmanının hâkim kılındığı öykülerde yer verilen sıradan insanların ve anlatıcı-yazar kimliğiyle kendini kurguya dâhil eden Eray’ın düş atmosferi içinde imkânsızı ve olağanüstüyü mümkün kıldığı görülür. Yazar, gerçek dışılığı, fantastiği, fizik ötesi durumları ve olağanüstülüğü sağlamak için düşün kendisine sunduğu olanaklarla öykülerini kurgular. Bu bildiride Nazlı Eray’ın öykülerinde geniş yer tutan rüya motifleri, psikanalitik edebiyat kuramı çerçevesinde değerlendirilecek ve yazarın rüyayı bir kurgulama tekniği olarak kullanımına analitik bir yaklaşım sergilenecektir.Nazlı Eray who is one of the most important fantasy author in Turkish storytelling has never changed her style and built her literary works on fantasies since the beginning of her literary career. Eray’s early works are considered to be on the same line with Sait Faik’s by the literary society for her treating ordinary and rejected people in a sensible way in her stories. In her stories, the author who treats these characters and their lives with sympathy fulfills both her own and rejected people’s longings and their expectations from life by fantasising. One of the most important veins that feeds her fantasy style isdreams. Dreams have many functions in her stories and that leads her stories to be analysed within the frame of psychoanalytic literary theory. She uses the reality and fantasy together and creates a different reality in her stories in which ordinary people and she herself as the narrator take part. It can be seen that she makes the unthinkable and supernatural possible in an atmosphere of dream. The author fictionalises her stories with the oppurtunities the dreams offer to ensure supernatural and metaphysical situations. In this study, dream motives taking a wide part in Nazlı Eray’s stories is examined in the frame of psychoanalytic literary theory and the author’s using dream as a setting up technique is analysed
- …
