28 research outputs found
A Comparative Genomic Analysis of Georgenia sps. for Mining of LysR Transcriptional Regulator Sequences
No full textGeorgenia is a genus belonging to the actinomycetes group. The genera comprise only 33 poorly characterized species with reference genomes of 10 distinct species. However, none of the species is well characterized for their genome characteristics. Our laboratory isolate from tomato plant leaf was identified and sequenced for identification and found to be Georgenia sp. Later genomic analysis revealed many functional genes having characteristic functions to be analysed. The source of isolation raised the possibility of having functional genes to enhance senescence or having plant pathogenic activity by Georgenia sp. SUBG003. To explore in silico presence of these genes or gene pools genomic islands were identified and analysed for our isolate and other 10 reference genomes of the Georgenia genus. Genomic islands were further explored for transcription regulators and finally, LysR transcriptional regulator sequences were extracted and a phylogeny among sequences was built from multiple sequence alignment
Examination of Present Subsurface Investigation Data for Valuation of Liquefaction Potential for Ahmadabad City by Means of SPT-N Value
No full textExamination and Appraisal of Liquefaction Vulnerability Between Idriss–Boulanger Method and Andrus–Stokoe Method
No full textA retrospective and prospective chart review with implementations: preventing non-urgent emergency department visits from a primary care practice
No full textPurpose: Often there are patients who visit the emergency department for non-urgent complaints that can be treated in the primary care setting. This can lead to overcrowding of the emergency department, increased costs, and delay in treatment times. Providers need to advise or educate patients on the use of the emergency department versus the primary care practice. Doing so may lead to better use of the primary care providers, decrease non-urgent visits to the emergency departments and improve patient outcomes.
Methodology: A retrospective chart review with implementation of a handout was on display at a privately owned primary care practice in northern New Jersey. The handout displayed examples of services available in the emergency department versus those in the primary care practice. Prospective evaluation via a chart review of patient utilization of the emergency department was collected after handout has been available to patients. Data was analyzed for a decrease in patients utilizing the emergency department. The retrospective chart review, implementation of patient viewing handouts, and prospective chart review was utilized to develop recommendations based on the findings to promote primary care use and help decrease non-urgent emergency department visits.
Results: The statistical results revealed that most of the emergency department visits were emergent. Although emergency department visits after the implementation, the results were not statistically significant due to small sample size.
Implications for Practice: One time evaluation of patient Rapid Estimate of Adult Literacy in Medicine (REALM) score to determine baseline healthcare literacy. This will assist in educating of the patient and providers to determine what level of counseling they can provide the patient. Recommendations for additional practice hours as well as having additional providers to assist with patient volume. Utilization of call service when office is closed. Documentation of counseling of the patient for reimbursement.D.N.P.Includes bibliographical reference
Application of Building Information Modeling in Facility Management: A Case Study of a Commercial Project
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Author response
No full textA well-characterized metabolic landmark for aggressive cancers is the reprogramming from oxidative phosphorylation to aerobic glycolysis, referred to as the Warburg effect. Models mimicking this process are often incomplete due to genetic complexities of tumors and cell lines containing unmapped collaborating mutations. In order to establish a system where individual components of oncogenic signals and metabolic pathways can be readily elucidated, we induced a glycolytic tumor in the Drosophila wing imaginal disc by activating the oncogene PDGF/VEGF-receptor (Pvr). This causes activation of multiple oncogenic pathways including Ras, PI3K/Akt, Raf/ERK, Src and JNK. Together this network of genes stabilizes Hifα (Sima) that in turn, transcriptionally up-regulates many genes encoding glycolytic enzymes. Collectively, this network of genes also causes inhibition of pyruvate dehydrogenase (PDH) activity resulting in diminished ox-phos levels. The high ROS produced during this process functions as a feedback signal to consolidate this metabolic reprogramming
