222 research outputs found
8-Methoxypsoralen plus UVA treatment increases the proportion of CLA+ CD25+ CD4+ T cells in lymph nodes of K5.hTGFβ1 transgenic mice
No full text8-Methoxypsoralen plus UVA (PUVA) photochemotherapy is an effective treatment for many skin diseases including psoriasis. However, its exact mechanism of therapeutic action is incompletely understood. Previously, in K5.hTGF beta 1 transgenic psoriatic mice, we found that PUVA induces Foxp3+ CD25+ CD4+ regulatory T cells in both lymph node and spleen. Now, in the same model, we investigated whether cutaneous lymphocyte-associated antigen (CLA) mediates PUVAs effect on homing of CD25+ CD4+ T cells to the lymph nodes of K5.hTGF beta 1 transgenic mice. We found that a low dose of topical PUVA maximally increased the proportion of CLA + CD25+ CD4 + T cells in the lymph nodes by up to 8-fold. We also observed an increased number of Foxp3+ CD25+ T cells in the skin of the mice after PUVA treatment. Together, these findings suggest that PUVA affects the homing of regulatory T cells
sj-docx-1-pie-10.1177_09544089221150718 - Supplemental material for Hybrid surface modification for improved tribological performance of IC engine components – a review
No full textSupplemental material, sj-docx-1-pie-10.1177_09544089221150718 for Hybrid surface modification for improved tribological performance of IC engine components – a review by Govind Murari, Binayaka Nahak and Tej Pratap in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
PIC880209 Supplemental Material - Supplemental material for Fluid flow analysis of a turbulent offset jet impinging on a wavy wall surface
No full textSupplemental material, PIC880209 Supplemental Material for Fluid flow analysis of a turbulent offset jet impinging on a wavy wall surface by Tej Pratap Singh, Amitesh Kumar and Ashok Kumar Satapathy in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science</p
Treg/Th17 axis in 8-methoxypsoralen plus ultraviolet-A response of a psoriasis-like skin disorder in mice
No full textTh17/Treg paradigm: effect of 8-methoxypsoralen plus ultraviolet A in a mouse model of psoriasis
No full textTh17/Treg paradigm: effect of 8-methoxypsoralen plus ultraviolet A in a mouse model of psoriasis
No full textPlatelet-activating factor blockade inhibits Th17 pathway and suppresses psoriatic-like skin disease in K5.hTGF-beta1 transgenic mice
No full textPlatelet-activating factor blockade inhibits Th17 pathway and suppresses psoriatic-like skin disease in K5.hTGF-beta1 transgenic mice
No full textRole of IL-9 in Th17-associated inflammation, hyperproliferation, and angiogenesis in psoriasis
No full textRole of IL-9 in Th17-associated inflammation, hyperproliferation, and angiogenesis in psoriasis
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