65 research outputs found
Biosurfactant coated silver and iron oxide nanoparticles with enhanced anti-biofilm and anti-adhesive properties
No full textPseudomonas aeruginosa and Staphylococcus aureus are among the hazardous biofilm forming bacteria ubiquitous in industrial/clinical wastes. Serious efforts are required to develop effective strategies to control surface-growing antibiotic resistant pathogenic bacterial communities which they are emerging as a global health issue. Blocking hazardous biofilms would be a useful aspect of biosurfactant coated nanoparticles (NPs). In this regard, we report a facile method for the synthesis of rhamnolipid (RL) coated silver (Ag) and iron oxide (Fe3O4) NPs and propose the mechanism of their synergistic antibacterial and anti-adhesive properties against biofilms formed by P. aeruginosa and S. aureus. These NPs demonstrated excellent anti-biofilm activity not only during the biofilms formation but also on the pre-formed biofilms. Mechanistically, RL coated silver (35 nm) and Fe3O4 NPs (48 nm) generate reactive oxygen species, which contribute to the antimicrobial activity. The presence of RLs shell on the nanoparticles significantly reduces the cell adhesion by modifying the surface hydrophobicity and hence enhancing the anti-biofilm property of NPs against both mentioned strains. These findings suggest that RL coated Ag and Fe3O4 NPs may be used as potent alternate to reduce the infection severity by inhibiting the biofilm formation and, therefore, they possess potential biomedical applications for antibacterial coatings and wound dressings.</p
بشریٰ رحمٰن کے ناول "پیاسی" کا فکری و فنی جائزہ : INTELLECTUAL AND ARTISTIC REVIEW OF BUSHRA REHMAN'S NOVEL "PIYASI"
No full textBushra Rehman is a unique novelist who sheds light on our social issues, economic and political life events through his novels. At the same time, she makes the exploitation of women a topic because she is a keen observer of women's psychology. This is the language that is spoken in our society. The novel theme of the novel depicts love, social issues and the mental struggles of middle-class women and the exploitation of women. The extension of rights is wide. This novel is a beautiful confluence of such topics. In this novel, there is height and depth of art in the mind of the author and the plot keeps moving forward at its own pace. The novel is also alive
Relationship between circulating levels of IFN‐γ, IL‐10, CXCL9 and CCL2 in pulmonary and extrapulmonary tuberculosis is dependent on disease severity
No full textProtection against Mycobacterium tuberculosis infection is dependent on T cell and macrophage activation regulated by cytokines. Cytokines and chemokines produced at disease sites may be released into circulation. Data available on circulating cytokines in tuberculosis (TB) is mostly on pulmonary TB (PTB) with limited information on extrapulmonary disease (EPul-TB). We measured interferon-gamma (IFN-γ), interkeukin-10 (IL-10), CXCL9 and CCL2 in sera of patients ( n = 80) including; PTB ( n = 42), EPul-TB ( n = 38) and BCG vaccinated healthy endemic controls (EC, n = 42). EPul-TB patients comprised those with less severe (LNTB) or severe (SevTB) disease. Serum IFN-γ, IL-10 and CXCL9 levels were significantly greater while CCL2 was reduced in TB patients as compared with EC. IFN-γ was significantly greater in PTB as compared with LNTB ( P = 0.002) and SevTB ( P = 0.029). CXCL9 was greater in PTB as compared with LNTB ( P = 0.009). In contrast, CCL2 levels were reduced in PTB as compared with LNTB ( P = 0.021) and SevTB ( P = 0.024). A Spearman’s rank correlation analysis determined a positive association between IFN-γ and IL-10 (rho = 0.473, P = 0.002) and IFN-γ and CXCL9 (rho = 0.403, P = 0.008) in the PTB group. However, in SevTB, only IFN-γ and CXCL9 were positively associated (rho = 0.529, P = 0.016). Systemic levels of cytokines are reflective of local responses at disease sites. Therefore, our data suggests that in PTB increased IFN-γ and CXCL9 balanced by IL-10 may result in a more effective cell mediated response in the host. However, elevated inflammatory chemokines CXCL9 and CCL2 in severe EPul-TB without concomitant down modulatory cytokines may exacerbate disease related pathology and hamper restriction of M. tuberculosis infection. [ABSTRACT FROM AUTHOR]Peer reviewedfinal article publishe
Thermal surface analysis on high-rise building façades with neo-minimalist and modern style in Penang, Malaysia
No full textA microsatellite study for determination of allelic variation of Kurdish population-Kurdistan region-Iraq
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THE INFLUENCE OF CORONAVIRUS ON THE HIGHER EDUCATION SERVICES (CASE STUDY OF ISRAEL & MOLDOVA)
No full text<p><i><strong>Abstract</strong>: The trends of growing demand among learners in higher education systems leading for improved accessibility and convenience, lower costs, and direct application of content to work settings in the institutes. This radically changing the local and international environment for higher education system. The new phenomenon of using technical methods is demand the competition between the organization. If we look at the United States and globally (other countries), in this rapidly changing environment, which is increasingly based within the context of a global and knowledge-based economy and competition between higher education systems. The author found that higher education organizational in Israel and Moldova have changes, and new developments are being fueled by accelerating advances. The author will describe the local situation and the trends in the Israeli & Moldavian higher education system.</i></p>
Gravity Field Uncertainty Analysis for Ganymede Orbit Phase of the JUICE mission: An error propagation
No full textThe Ganymede Circular Orbit Phase (GCO-500) of the JUICE mission will bethe first time a moon beyond Earth’s will be orbited for an extended period of 9 months. This orbit phase, due to its close proximity, opens the window to more accurately determine the spacecraft orbit and thereby unambiguously characterize the interiors of the Galilean moons. Ganymede is believed to harbor an internal ocean and will help understand the habitability of icy worlds in the outer solar system.In this study results of a sensitivity analysis are presented which investigate the settings of a model developed for the GCO-500 phase. The model aims to realistically emulate the JUICE mission concept, by specifically focusing on the radio science experiment 3GM, responsible for estimating the gravity field. The model also includes non-gravitational accelerations which are accountedfor by the High Accuracy Accelerometer (HAA).Aerospace Engineerin
Chronicle of a revolution in between literature and journalism, conservative claims and progressive struggles : revolution Bushrā al-Maqṭarī’s literary articles
No full textBushra al-Maqtari, a Yemeni journalist and writer, is the author of a particular genre: literary article. A kind of work which is in between a short story and a journalistic article. She kept writing during the events of the Youth Revolution (2011), denouncing the abuses of the authority and the actions of the so called “thieves of Yemeni revolutions” that is: the army, the political parties, the tribes and the religious movements. Using the maqala adabiyya (literary article), al-Maqtari makes a kind of revolution in the Yemeni literature, restoring an almost forgotten literary genre
Synthesis and characterization study of n-Bi2O3/p-Si heterojunction dependence on thickness
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