172,573 research outputs found
Extensions of picard 2-stacks and the cohomology groups Exti of length 3 complexes
No full textThe aim of this paper is to define and study the 3-category of extensions of Picard 2-stacks over a site S and to furnish a geometrical description of the cohomology groups Exti of length 3 complexes of abelian sheaves. More precisely, our main theorem furnishes (1) a parametrization of the equivalence classes of objects, 1-arrows, 2-arrows, and 3-arrows of the 3-category of extensions of Picard 2-stacks by the cohomology groups Exti, and (2) a geometrical description of the cohomology groups Exti of length 3 complexes of abelian sheaves via extensions of Picard 2-stacks. To this end, we use the triequivalence between the 3-category 2Picard(S) of Picard 2-stacks and the tricategory T[−2,0] (S) of length 3 complexes of abelian sheaves over S introduced by the second author in [12], and we define the notion of extension in this tricategory T[−2,0] (S), getting a pure algebraic analog of the 3-category of extensions of Picard 2-stacks. The calculus of fractions that we use to define extensions in the tricategory T[−2,0] (S) plays a central role in the proof of our main theorem
Tatar Türkçesinde cümle
No full textTürkçenin kuzey-batı ( Kıpçak ) koluna dahil edilen Tatar Türkçesi, bugün Kazan merkez olmak üzere İdil-Ural bölgesinde ve Kırım'da konuşulmaktadır. Biz İdil-Ural bölgesinde konuşulan Kazan Tatar Türkçesini cümle unsurları ve cümle çeşitleri bakımından inceledik. Çalışmamızda Türkiye Türkçesiyle Tatar Türkçesini sentaks bakımından karşılaştırmayı amaçladık. Kökleri aynı olan bu iki yazı dili arasında cümle bilgisi bakımından ne tür benzerlikler ya da farklılıklar bulunduğunu tespit etmeye çalıştık. Çalışmamız üç ana bölümden oluşuyor : a. Giriş b. İnceleme c. Sonuç. a. Giriş. Bu bölümde ilk olarak Tatar kelimesi ve Tatar Türkleri ile ilgili tarihî bilgi verildi. Daha sonra, Tatar edebiyatı ve dilinin gelişimine değinildi. Son olarak Tatar Türkçesi üzerinde yapılan sentaks araştırmaları ile ilgili bibliyografik bilgi verildi. b. İnceleme. Bu bölümde Tatar Türkçesinde cümle konusu ele alındı. Cümle iki ana başlık altında incelendi : 1. Cümle unsurları 2. Cümle türleri. Cümle unsurları bölümünde ilk olarak, araştırmacılar m yaptığı cümle tanımları değerlendirildi. Bunun ardından, cümle unsurları Tatar Türkçesiyle yazılmış eserlerden alınan cümle örnekleri yardımıyla açıklandı. Cümle türleri bölümünde Tatar Türkçesindeki cümleler dört farklı kritere göre sınıflandırıldı. Cümleler yapılarına, yüklemlerinin kelime çeşidine, yüklemlerinin cümledeki yerine ve son olarak da anlamlarına göre incelendi. c. Sonuç. Çalışmamızın üçüncü bölümü olan sonuçta Türkiye Türkçesi ve Tatar Türkçesi sentaks özellikleri bakımından karşılaştırıldı. Bu karşılaştırmada Tatar ve Türkiye gramerciliği arasındaki farklı yaklaşımlar da değerlendirildi
Main facade of Madrasat Tatar al-Higaziya
No full textPhotographer's description: Madrassat Tatar el Hégaziéh. Façade principale. Translation of photographer's description: Madrassa of Tatar el Hegazieh Main Facade. Collector's note: - 6 Tatar al Hegaziah Façade nord. Mosque of Tatar el-Hegâzieh. Translation of collector's note: - 6 Tatar al Hegaziah North facade
Higher-dimensional study of extensions via torsors
No full textLet S be a site. First we define the 3-category of torsors under a Picard S-2-stack and we compute its homotopy groups. Using calculus of fractions, we define also a pure algebraic analogue of the 3-category of torsors under a Picard S-2-stack. Then we describe extensions of Picard S-2-stacks as torsors endowed with a group law on the fibers. As a consequence of such a description, we show that any Picard S-2-stack admits a canonical free partial left resolution that we compute explicitly. Moreover, we get an explicit right resolution of the 3-category of extensions of Picard S-2-stacks in terms of 3-categories of torsors. Using the homological interpretation of Picard S-2-stacks, we rewrite this three categorical dimensions higher right resolution in the derived category D(S) of abelian sheaves on S
Body image and its relationship with exercise and sports in Turkish lower-limb amputees who use prosthesis
No full textPurpose. - In this study, we investigated whether Turkish lower-limb amputees (LLA) using prosthesis, who participate in sports and exercise activities, have a different body image from those who do not participate in such physical activities. Method. - For this evaluation, we used the Amputee Body Image Scale (ABIS); in addition, a questionnaire for assessment of demographic characteristics of the subjects and issues regarding use of the prosthesis was applied. The study was conducted on 17 Turkish LLA participating in sports and exercise, and on 20 Turkish LLA not participating in sports and exercise activities. Results. - The mean ABIS score of LLA participating in sports and exercise was 25,5 +/- 7,33; mean ABIS score of LLA not participating in sports and exercise was 35,94 +/- 12,24; this difference was statistically significant (Mann-Whitney U, p < 0.05). ABIS scores for men and women were similar, regardless of participation in exercise and sports. (C) 2010 Elsevier Masson SAS. All rights reserved
Corner in the courtyard of Madrasat Tatar al-Higaziya
No full textPhotographer's description: Madrassat Tatar el Hégaziéh. Translation of photographer's description: School of Tatar el Hegazieh. Collector's note: 8) Coin nord-ouest du Sahn. Mosque of Tatar el-Hegâzieh. Translation of collector's note: - 8) North-West corner of the Sahn
Novel 4-Thiazolidinones as Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase
No full textIn continuation of our efforts to develop new derivatives as hepatitis C virus (HCV) NS5B inhibitors, we synthesized novel 5-arylidene-4-thiazolidinones. The novel compounds 29-42, together with their synthetic precursors 22-28, were tested for HCV NS5B inhibitory activity; 12 of these compounds displayed IC50 values between 25.3 and 54.1 mu M. Compound 33, an arylidene derivative, was found to be the most active compound in this series with an IC50 value of 25.3 mu M. Molecular docking studies were performed on the thumb pocket-II of NS5B to postulate the binding mode for these compounds
Authorship problem of the seventeenth-century pasquinade "Tatar Al-Furqan": doubts and findings
No full textThe article attempts to identify the author of a seventeenth-century pasquinade Alfurkan tatarski (Tatar Al-Furqan) aimed against the Tatars of the Grand Duchy of Lithuania, or more precisely, those living on the Vokė River in the Trakai voivodeship. The author has analysed the dedications and commentaries to four editions (1616, 1617, 1640, and 1643), paying attention to the life of the Benedictine abbot of Senieji Trakai monastery, Tomasz Pawłowski (c. 1556–1653), who administered the abbey in the years between after 1597 and 1617. The coincidence of his biographical data with the dates of successive editions of the Alfurkan suggests that he could have been the mysterious author of the text. Keywords: Tatars of the Grand Duchy of Lithuania, anti-Tatar pasquinade, Piotr Czyżewski, Senieji Trakai, Benedictine monastery, Abbot Tomasz Pawłowski
Small-Molecule Inhibitors Targeting Sterol 14 alpha-Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation AgainstCandida albicans
No full textFungal infections are a global issue affecting over 150 million people worldwide annually, with 750 000 of these caused by invasiveCandidainfections. Azole drugs are the frontline treatment against fungal infections; however, resistance to current azole antifungals inC. albicansposes a threat to public health. Two series of novel azole derivatives, short and extended derivatives, have been designed, synthesised and investigated for CYP51 inhibitory activity, binding affinity and minimum inhibitory concentration (MIC) againstC. albicansstrains. The short derivatives were more potent against theC. albicansstrains (e. g., MIC 2-(4-chlorophenyl)-N-(2,4-dichlorobenzyl)-3-(1H-imidazol-1-yl)propanamide (5 f) <0.03 mu g/mL,N-(4-((4-chlorophenyl)sulfonamido)benzyl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propanamide (12 c), 1 mu g/mL, fluconazole 0.125 mu g/mL) but both displayed comparable enzyme binding and inhibition (5 fK(d)62 +/- 17 nM, IC(50)0.46 mu M;12 cK(d)43 +/- 18 nM, IC(50)0.33 mu M, fluconazoleK(d)41 +/- 13 nM, IC(50)0.31 mu M, posaconazoleK(d)43 +/- 11 nM, IC(50)0.2 mu M). The short series had poor selectivity for CaCYP51 over the human homologue, whereas the selectivity of the extended series, for example, compound12 c, was higher (21.5-fold) than posaconazole (4.7-fold) based onK(d)values, although posaconazole was more selective (615-fold) than12 c(461-fold) based on IC(50)values. Based on inhibitory activity and selectivity profile, the extended series are the better of the two series for further development
Building Corpus-Based Semantic Classifications of Some Tatar Affixes
No full textThis study is aimed at exploring the semantic properties of Tatar affixes. Turkic languages have complicated morphology and syntax, which is a challenge for language processing.The fundamental principle of inflection and derivation in Tatar, as well as in other Turkic languages, is agglutination, when the stem joins postpositive affixes in a strictly determined order.The Tatar language has affixes of different types:a) derivational affixes expressing only lexical meaning and forming new words;b) inflectional affixes changing the word form (for example, case affixes);c) affixes serving as means of derivation as well as inflection.The current study is devoted to the ambiguous Tatar –lık polyfunctional affix which may be joined to nominal, adjectival and verbal stems and form derivatives of different types depending on contextual environment, the meaning of the stem and the composition of the affixal chain of a derivative. -Lık affix is a productive affix in modern Tatar which builds nominal, adjectival and verbal derivatives.The answer to the question of the number of the types of derivatives and word forms produced with -lık affix is not trivial, and different researchers distinguish different types of derivatives.Based on a thorough analysis of Tatar derivatives containing - lık affix we identified some empirical features of these constructs and then performed their manual and automatic classification. Four classes were distinguished. For our experiments we used data from the Tatar National Corpus “Tugan Tel” (http://corpus.antat.ru).The results obtained may be used for disambiguation in Tatar National Corpus and for analyzing other Tatar ambiguous affixes.</jats:p
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