59 research outputs found
Biological activities of the Ornithogalum orthophyllum and its in silico ADMET profile
No full textBackground: The bulbs and aerial parts of Ornithogalum are used in Turkey both as food and to treat various ailments, and some of its medical applications are well known. However, the biological activities of Ornithogalum orthophyllum have not yet been investigated. The objective of this study was to examine the antioxidant, urease and cholinesterase enzyme inhibition, and cytotoxic activities of different extracts obtained from the bulb and aerial parts of the O. orthophyllum plant. In addition, the absorption, distribution, metabolism, excretion, and toxicity properties of some phenolic compounds in plants were examined in silico. Methods: The antioxidant activity of the extracts obtained from the aerial parts of O. orthophyllum was investigated using the 2,2-diphenyl-1-picrylhydrazyl, 2,2-azinobis- (3-ethylbenzothiazoline-6-sulphonic acid), ferric reducing antioxidant power, and cupric reducing antioxidant capacity methods. Urease and cholinesterase enzyme inhibition were determined by using the indophenol and Gilman methods, respectively. The cytotoxic activity of the extracts was measured using a test based on the luminometric readings of the adenosine triphosphate levels of the cells. pkCSM, a free online web server (http://structure.bioc.cam.ac.uk/pkcsm) was used to predict the properties of the compounds analyzed. Results: The methanol extract of the aerial parts of O. orthophyllum was observed to have strong antioxidant and acetylcholinesterase enzyme inhibition potential. The petroleum ether extract of the aerial parts showed the highest anti-urease activity. The chloroform extract of the aerial parts exhibited the highest cytotoxic effect against A431 human epidermoid carcinoma cells. The absorption percentages of protocatechuic acid, p-hydroxybenzoic acid, vanillic acid, and p-coumaric acid compounds from the small intestine were between 71.17% and 93.49%, which were quite high. All the compounds were predicted to be unable to penetrate the central nervous system due to their inability to cross the blood-brain barrier. Not all compounds analyzed were predicted to have mutagenic, hepatotoxic, or minnow toxicity effects. Conclusion: The extracts obtained from the aerial parts of O. orthophyllum have strong biological activity and contain compounds that arc well-absorbed and do not have mutagenic, hepatotoxic, or minnow toxicity effects, suggesting that they can be used as natural medicinal and nutritional sources in the future
Scientific people named in the classification of vasculitis
No full textAbstract The first International Chapel Hill Consensus Conference was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second Chapel Hill Consensus Conference 2012, which were not included in the Chapel Hill Consensus Conference 1994. The new nomenclature was introduced instead of being referred to by many names such as Churg-Strauss and Wegener"s. New categories such as Behçet"s and Cogan etc. were also added. These people are honored by the classification. They contribute to science through their case studies, scientific articles, and observations. This article reviews only eponyms present in the current classification of vasculitis. The aim of this paper is to give information about scientists mentioned in the classification of vasculitis
Scientific people named in the classification of vasculitis
No full textAbstractThe first International Chapel Hill Consensus Conference was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second Chapel Hill Consensus Conference 2012, which were not included in the Chapel Hill Consensus Conference 1994. The new nomenclature was introduced instead of being referred to by many names such as Churg-Strauss and Wegener”s. New categories such as Behçet”s and Cogan etc. were also added. These people are honored by the classification. They contribute to science through their case studies, scientific articles, and observations. This article reviews only eponyms present in the current classification of vasculitis. The aim of this paper is to give information about scientists mentioned in the classification of vasculitis
Nomes de cientistas usados na classificação das vasculites
No full textResumoA primeira International Chapel Hill Consensus Conference (CHHC) ocorreu em 1994. Fizeram‐se sugestões sobre a nomenclatura das vasculites sistêmicas. Na segunda CHHC, 2012, adicionaram‐se importantes categorias à classificação da vasculite e fizeram‐se várias mudanças em nomes de doenças que não estavam incluídas na CHCC 1994. Introduziu‐se uma nova nomenclatura em vez de se usarem nomes como Churg‐Strauss e Wegener. Também foram adicionadas novas categorias, como de Behçet e Cogan etc. Essas pessoas são homenageadas pela classificação. Elas contribuíram para a ciência com seus estudos de caso, artigos científicos e observações. Este artigo analisa apenas epônimos presentes na classificação atual das vasculites. O objetivo é prestar informações sobre os cientistas mencionados na classificação das vasculites.AbstractThe first International Chapel Hill Consensus Conference (CHHC) was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second CHHC 2012, which were not included in the CHCC 1994. The new nomenclature was introduced instead of being referred to by many names such as Churg‐Strauss and Wegener”s. New categories such as Behçet”s and Cogan etc. were also added. These people are honored by the classification. They contribute to science through their case studies, scientific articles, and observations. This article reviews only eponyms present in the current classification of vasculitis. The aim of this paper is to give information about scientists mentioned in the classification of vasculitis
In vivo effects of radioactive properties of Tl-201 on human carbonic anhydrase activity
No full text
In vitro effects of radioactive properties of 99mTc and 99mTc-MDP on human glucose 6-phosphate dehydrogenase activity
No full textThe relationship between platelet distribution width and disease activity in patients with polymyositis
No full textINTRODUCTION: Muscle enzymes are an indicator of ongoing muscle damage and disease activity in patients with idiopathic inflammatory myopathy. Although platelet-related parameters have been shown to be useful as markers of disease activity in autoimmune diseases, the relationship between platelet distribution width (PDW) and disease activity has not been previously studied in polymyositis. We aimed to determine the relationship between PDW and disease activity in patients with polymyositis. MATERIAL AND METHODS: Twenty-seven patients with polymyositis and thirty healthy controls were included in the study. Disease activity was evaluated using the myositis disease activity assessment Visual Analogue Scale (MYOACT) and the Myositis Intention to Treat Index (MITAX). The relationship between PDW and disease activity was evaluated using Pearson’s or Spearman’s correlation and reliability was assessed using correlation coefficients. RESULTS: The mean platelet volume (MPV) and plateletcrit (PCT) were significantly higher and PDW was significantly lower in patients with polymyositis compared to the control group. The mean PDW levels were lower in patients with constitutional symptoms and arthralgia/arthritis (p < 0.005). Although PDW levels were lower in patients with mechanical hand, lung involvement, or dysphagia compared to patients without, there was no statistically significant difference between them. Platelet distribution width was found to be negatively correlated with disease activity. CONCLUSIONS: We found that PDW was negatively correlated with MYOACT and MITAX, widely used tools in assessing the disease activity of polymyositis. Based on this, PDW may be utilized as a non-invasive potential index to assess disease activity in patients with polymyositis
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