74 research outputs found
Pemphigus Vulgaris in Old Patient
No full textPemphigus vulgaris (PV) is a chronic, autoimmune, intraepidermal blistering disease of the skin and mucous membranes. The first clinical manifestation is often the development of intraoral lesions, and later, the lesions involve the other mucous membranes and skin. The etiological factors of this disease still remain unknown, although the presence of autoantibodies is consistent with an autoimmune disease. A 73-year-old man had bullous lesions on gingiva, oral mucosa first, then scalp, trunk, and face. An oral medicine specialist suspects the lesion in differential diagnosis in the first presentation of oral lesions and follows up the patient, and then these bullous lesions presented on the skin. In this article, a patient had received oral prednisolone (80 mg/kg/day) and azathioprine, then tapered oral prednisolone to 40 mg/day, with a reduction of 5 mg/day every three weeks. The patient shows remission of these lesions, and complication of this treatment includes osteoporosis, hyperglycemia, and hypertension
Factors associated with hematoma of the floor of the mouth after placement of dental implants
No full textAbstractPurposeThe aim of this article is to determine factors associated with hematoma during placement of dental implants in the anterior mandible and to provide the dental practitioner with preventive measures to avoid such a life-threatening complication.MethodsAll available clinical case studies from (1986 to 2010) published in English or with English abstract were reviewed and analyzed.ResultsNineteen studies have been identified and written in the literature. Most of the reported studies were case series and they showed that hematoma is a very rare complication, but general dental practitioners do not pay attention to the significance of the mandible anatomy in the anterior area and the possibility of perforation of the lingual cortex during placement of the dental implants in that position.ConclusionsThe use of dental CT in planning the implant treatment coupled with accurate determination of implant length in order to provide detailed data about the mandible anatomy are highly recommended to avoid the occurrence of hematoma in the floor of the mouth and the airway obstruction that may lead to death during placement of dental implants in the anterior mandible
Reactivation of COVID‐19—14 days from the onset of symptoms may not be enough to allow dental treatment
No full textImmunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma (undifferentiated and adenocarcinoma types)
No full textObjective: Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma. Study design: A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined. Results: The results showed that p21 expression was negative in the most components of normal tissue of the salivary gland surrounding pleomorphic adenoma, 24 cases out of 29 of the non tumour duct cells (82.8%), and 28 (96.6%) cases out of 29 of the acinar cells shows negative p21 expression. P21 expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells. p21 was strongly expressed in carcinoma cells in 9 (33.3%) cases out of 27. Conclusion: Our data suggest that the strong nuclear staining as an indicator for altered p21, then the alteration of p21 expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 33.3%)
Immunohistochemical expression of oestrogens and progesterone receptors in carcinoma ex pleomorphic adenoma- undifferentiated and adenocarcinoma types
No full textCancer of the salivary gland is one of the common cancers in the head and the neck regions. This type of cancer develops in the minor and the major salivary glands, and it sometimes metastasizes to other organs, particularly the lung. Morphologic mimicry and similarity in the expression of steroid hormone receptors between salivary gland tumors and breast tumors are well-known phenomena and are occasionally debated in the field of surgical pathology. The expression of sex hormone receptors in some tumors suggests a role for these receptors in tumor pathogenesis and therapy. Previous studies of the expression of estrogens and progesterone receptors in salivary gland tumors have reported conflicting results. Objective: Our study aimed to characterize alteration in the immunohistochemical expression of estrogens receptor and progesterone receptor in the tumor cells of carcinoma arising in pleomorphic adenoma. Study design: 27 cases of carcinoma arising in pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined. Results: The results showed that 27 (100 %) of 27 cases had negative nuclear staining for either estrogens or progesterone receptors. Conclusion: Our data suggest that carcinomas arising in pleomorphic adenoma were not dependent on endocrine function
Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma
No full textContext. Immunohistochemical stains for p53 are used as a diagnostic marker associated with malignancy in several histologic types of salivary gland tumors. This marker may be useful in differentiating pleomorphic adenoma (PA) from carcinoma ex pleomorphic adenoma (CPA), as these tumors are often difficult to distinguish on the basis of morphology alone.Objective. to evaluate whatever inactivation of tumor suppressor gene (p53) increases with the tumor progression from normal salivary tissue to PA and eventually CPA.Design. Paraffin blocks of 29 cases of PA, which were surrounded by normal parotid gland, and 27 cases of carcinoma ex pleomorphic adenoma were retrieved and validated. In all cases of carcinoma ex pleomorphic adenoma, a PA “ghost” was identified, and the malignant element was either undifferentiated carcinoma or adenocarcinoma.Results. The results showed negative nuclear expression of P53 in normal parotid gland. Nuclear P53 was expressed strongly in 6/29 (20.7%) pleomorphic salivary adenoma and 10/27 (37%) carcinoma ex pleomorphic adenoma.Conclusion. Our data suggest that inactivation of p53 may play an important role in the evolution of pleomorphic salivary adenoma and carcinoma ex pleomorphic adenoma.</jats:p
The effect of dietary habits on the development of the recurrent aphthous stomatitis
No full textBackground: The aim was to assess the relationship between the dietary habits and development of recurrent aphthous stomatitis. Materials and Methods: Two groups (30 patients with RAS who have been following dietary habits and not associated with systemic disease or hematologic abnormalities, and the control group consist of 28 patients without recurrent aphthous stomatitis). Results: A Mann–Whitney test (P>0.05) shows no significance difference between the patients with RAS and the control group. Both groups eating similar food such as cheese, cow’s milk, tea, lemon, coffee, orange, apple, yoghurt, and tomato, spicy food, but the patients with RAS ate specific foods containing (pH) like; oranges and lemons more frequently than the control group. Conclusion: Dietary habits have no important role in development of RAS but can lay a minor role in the pathogenesis of RAS either by causing hypersensitivity or by deficiency of some vitamins and minerals.Key words: Aphthous stomatitis, dietary habits, recurrentNigerian Medical Journal | Vol. 53 | Issue 1 | January-March | 201
An immunohistochemical study of the distribution of p 16 protein in oral mucosa in smokers, non-smokers and in frictional keratosis
No full textObjective: Our study aimed to characterize alteration in the immunohistochemical p16 expression in normal oral mucosa and non-neoplastic hyperproliferative disorders (i.e. frictional keratosis and mucosa from smokers). Study design: 43 specimen of oral mucosa were examined using immunohistochemistry. Results: In normal mucosa, there was strong positive nuclear staining in a proportion of fibroblasts and endothelial cells in the lamina propria, with variable expression in nuclei of the epithelial layer. However, when the patient?s tobacco smoking was examined, p16 nuclear staining in oral epithelium was seen in 4/20 (20%) of smokers and 0/23 (0%) of non-smokers. In every case of frictional keratosis (n=11), there was strong nuclear staining of some basal and supra-basal cells. In addition, there was strong nuclear staining of parakeratinizing squamous in a band above the spinous layer. In clinically normal oral epithelium of smokers and in frictional keratosis, basal and supra-basal cells expressed strong p16 nuclear staining which was absent in the control tissue examined. Conclusion: Our data suggest that p16 expression may be involved in the long-term loss of proliferation in cell senescence of oral mucosa
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