74 research outputs found
Panel manipulation in social stress testing: The Bath Experimental Stress Test for Children (BEST-C).
No full textBACKGROUND: Whilst acute stress paradigms in adults make use of adult panel members, similar paradigms modified for child participants have not manipulated the panel. Most work has utilised an audience of adult confederates, regardless of the age of the population being tested. The aim of this study was to trial a social stress test for children that provided a meaningful environment using age-matched child peers as panel actors. METHODS: Thirty-three participants (7-11 years) underwent the Bath Experimental Stress Test for Children (BEST-C). Based on the Trier Social Stress Test (TSST), it comprises a shortened six-minute public speaking task and four-minute maths challenge. It differs from previous stress tests by using age-matched children on the panel, pre-recorded and presented as a live feed, and includes an expanded manipulation check of subjective experience. Salivary cortisol was assessed at four time points, pre-post stress testing; life events, daily hassles and coping strategies were measured through questionnaires. A simple numerical coding scheme was applied to post-test interview data. RESULTS: The BEST-C generated a typical stress and adaptation response in salivary cortisol (p=.032). Age and gender differences were observed during recovery. Cortisol responses mapped directly onto three distinct subjective response patterns: (i) expected response and recovery; (ii) expected response, no recovery; (iii) no response. CONCLUSIONS: The BEST-C, utilising child confederates of participant target age is a meaningful social stress test for children. This is the first social stress test developed specifically for children that manipulates panel characteristics by using child confederates and a pre-recorded sham panel. Greater cortisol responses to the test were also found to match subjective verbal accounts of the experience. It offers a meaningful acute stress paradigm with potential applications to other child and adolescent age groups. Furthermore, it leads the way in the use of panel manipulation in social stress testing
Psychosocial factors that influence children with immune related health conditions
No full textThis chapter examines resilience in children from a health psychology perspective, with a focus on the biopsychosocial approach and the science of psychoneuroimmunology. A central notion is that of resilience being both psychosocial and physiological in nature and that developing psychosocial resilience has the capacity to build physiological resilience. Immune-related conditions are of particular relevance in this context and three types of health conditions are examined in relation to resilience: atopic conditions including asthma and eczema; infectious diseases such as HIV/AIDS; and autoimmune conditions including diabetes, juvenile arthritis, and systemic lupus. In the first part of the chapter we discuss the definition and meaning of resilience and key theories in health psychology and psychoneuroimmunology which relate to resilience including that of stress and coping and the concept of allostasis and allostatic load. The second part of the chapter focuses on each of the three types of conditions, drawing from a range of studies, to examine psychosocial and biological characteristics of resilience and psychosocial interventions to develop resilience and facilitate resilient outcomes. Theory into practice is linked throughout the chapter and a summary model of resiliency characteristics and outcomes is presented
Children's implicit understanding of the stress-illness link: Testing development of health cognitions.
No full textOBJECTIVE: Innate knowledge and developmental stage theory have been used to explain children's understanding of concepts relating to health, illness, and stress. The aim of this study was to investigate the degree to which children demonstrate unconscious cognitive associations between the concepts of stress and illness. DESIGN: The study employed an experimental design using an age appropriate implicit association task. METHODS: Thirty-two children (5-11 years of age) completed the Preschool Implicit Association Test (PSIAT), a computer-based measure of reaction time to consistent (stress and illness) and inconsistent (stress and health) concept pairings. RESULTS: Whilst age group had a significant effect on reaction times (older children generally displaying faster reaction times than younger children), those as young as 5-6 years of age were able to demonstrate implicit associations between stress and illness using the PSIAT. There was also some indication that this association peaks at around 7-8 years of age. CONCLUSIONS: Findings support a combination of developmental stage theory and the innate theory of children's understanding. Whilst sample size is small, this study is the first to apply the PSIAT to the context of implicit cognitive associations between stress and illness in children. Findings have potential implications for the delivery of interventions to facilitate health promotion and development of positive health behaviours in children and indicate that even children as young as 5-6 years have some ability to relate to the concept that stress may influence illness. Statement of contribution What is already known on this subject? The way in which children understand health and illness is commensurate with their developmental stage and experience of illness. Children also appear to have a degree of innate understanding of health and illness and their causes. Furthermore, recent work suggests children have some innate understanding and knowledge of the concept of stress. What does this study add? This is the first study to use an implicit association task to assess children's understanding of stress and illness. Implicit stress-illness associations were seen in children as young as 5-6 years of age. Whilst sample size was small, this proof-of-concept study bridges disciplines to further understanding of health
Optimising and profiling pre-implementation contexts to create and implement a public health network intervention for tackling loneliness
No full textBackground: The implementation of complex interventions experiences challenges that affect the extent to which they become embedded and scaled-up. Implementation at scale in complex environments like community settings defies universal replication. Planning for implementation in such environments requires knowledge of organisational capacity and structure. Pre-implementation work is an important element of the early phase of preparing the setting for the introduction of an intervention, and the factors contributing towards the creation of an optimal pre-implementation community context are under-acknowledged. Methods: To explore the factors contributing towards the creation of an optimal pre-implementation context, a quasi-ethnographic approach was taken. The implementation of a social network intervention designed to tackle loneliness in a community setting acts as the case in example. Observations (of meetings), interviews (with community partners) and documentary analysis (national and local policy documents and intervention resources) were conducted. Layder's adaptive theory approach was taken to data analysis, with the Consolidated Framework for Implementation Research (CFIR) and a typology of third-sector organisations used to interpret the findings. Results: Community settings were found to sit along a continuum with three broad categories defined as Fully Professionalised Organisations; Aspirational Community, Voluntary and Social Enterprises; and Non-Professionalised Community-Based Groups. The nature of an optimal pre-implementation context varied across these settings. Using the CFIR, the results illustrate that some settings were more influenced by political landscape (Fully professional and Aspirational setting) and others more influenced by their founding values and ethos (Non-Professionalised Community-Based settings). Readiness was achieved at different speeds across the categories with those settings with more resource availability more able to achieve readiness (Fully Professional settings), and others requiring flexibility in the intervention to help overcome limited resource availability (Aspirational and Non-Professionalised Community-Based settings). Conclusions: The CFIR is useful in highlighting the multiple facets at play in creating the optimal pre-implementation context, and where flex is required to achieve this. The CFIR illuminates the similarities and differences between and across settings, highlighting the complexity of open system settings and the important need for pre-implementation work. Trial registration: ISRCTN19193075</p
Exploring cancer survivors’ views of health behavior change: "Where do you start, where do you stop with everything?"
No full textObjective: physical activity (PA) and a healthy diet can improve the well-being of cancer survivors. However, cancer survivors often do not engage in these behaviours. This study aimed to explore barriers and facilitators to engaging in these behaviours following cancer treatment.Methods: during the development of a web-based intervention to enhance health-related quality of life in cancer survivors, 32 people who had completed treatment for breast, colon or prostate cancer were presented with an intervention for PA and healthy eating. In-depth think-aloud and semi-structured interviewing techniques were used to elicit perceptions of both behaviours. Data were analysed using thematic analysis.Results: some individuals reported implementing positive health behaviour changes to maintain health and prevent recurrence, or to help them to move forward after cancer. However, others reported feeling abandoned, and many did not report an intention to engage in lifestyle changes. Individuals discussed contextual and healthrelated barriers that were specifically linked to their situation as post-treatment cancer survivors: individuals described uncertainty about how to implement adaptive changes and perceived a lack of support from healthcare providers. Others viewed behaviour change as unnecessary or undesirable, with some arguing that nonmodifiable factors contributed more to their cancer diagnosis than lifestyle-related factors.Conclusions: for many participants in this study, the period that follows treatment for cancer did not represent a ‘teachable moment’. A variety of complex and heterogeneous factors appeared to impact motivation, and may limit cancer survivors from engaging with diet and PA changes
Examining the optimal factors that promote implementation and sustainability of a network intervention to alleviate loneliness in community contexts
No full textCommunity environments have the potential to alleviate loneliness and social isolation as they offer opportunity for sociality and to expand personal social network connections. Implementing a social network intervention in community environments to connect people to who are at risk of loneliness or social isolation could help alleviate these concerns. However, implementing interventions in community environments is made difficult by the interplay between the community context and intervention. Thus, to support implementation a detailed understanding of the types of community contexts is required. To examine the optimal factors that promote the implementation of a social network designed to alleviate loneliness and social isolation intervention in the community observations, interviews and documentary analysis were conducted. The Consolidated Framework for Implementation Research and a typology of community contexts were used to inform the data analysis and interpret the findings. Key factors were found to affect the implementation of the intervention in the different community contexts. These inter-related factors operated across three domains. Service User Needs affected intervention take up as its suitability varied. The stability of the workforce and nature of everyday work also impacted on implementation. Finally, the fluctuating capacity of organisations and the organisational culture were also influential. No single community environment was found to have all of the optimal factors required for implementation and sustainably. The UK policy agenda of austerity had negatively affected community environments’ capacity to deliver such intervention through increasing service user needs and reducing available resources. Trial registration: ISRCTN19193075
Implementing a digital intervention for managing uncontrolled hypertension in Primary Care: a mixed methods process evaluation
No full textBackground: A high proportion of hypertensive patients remain above the target threshold for blood pressure, increasing the risk of adverse health outcomes. A digital intervention to facilitate healthcare practitioners (hereafter practitioners) to initiate planned medication escalations when patients’ home readings were raised was found to be effective in lowering blood pressure over 12 months. This mixed-methods process evaluation aimed to develop a detailed understanding of how the intervention was implemented in Primary Care, possible mechanisms of action and contextual factors influencing implementation. Methods: One hundred twenty-five practitioners took part in a randomised controlled trial, including GPs, practice nurses, nurse-prescribers, and healthcare assistants. Usage data were collected automatically by the digital intervention and antihypertensive medication changes were recorded from the patients’ medical notes. A sub-sample of 27 practitioners took part in semi-structured qualitative process interviews. The qualitative data were analysed using thematic analysis and the quantitative data using descriptive statistics and correlations to explore factors related to adherence. The two sets of findings were integrated using a triangulation protocol. Results: Mean practitioner adherence to escalating medication was moderate (53%), and the qualitative analysis suggested that low trust in home readings and the decision to wait for more evidence influenced implementation for some practitioners. The logic model was partially supported in that self-efficacy was related to adherence to medication escalation, but qualitative findings provided further insight into additional potential mechanisms, including perceived necessity and concerns. Contextual factors influencing implementation included proximity of average readings to the target threshold. Meanwhile, adherence to delivering remote support was mixed, and practitioners described some uncertainty when they received no response from patients. Conclusions: This mixed-methods process evaluation provided novel insights into practitioners’ decision-making around escalating medication using a digital algorithm. Implementation strategies were proposed which could benefit digital interventions in addressing clinical inertia, including facilitating tracking of patients’ readings over time to provide stronger evidence for medication escalation, and allowing more flexibility in decision-making whilst discouraging clinical inertia due to borderline readings. Implementation of one-way notification systems could be facilitated by enabling patients to send a brief acknowledgement response. Trial registration: (ISRCTN13790648). Registered 14 May 2015.</p
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies
No full textMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR 1-19 and RPGR ORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors
“Every day I worry about something":A qualitative exploration of children’s experiences of stress and coping
No full textObjectives: Most research investigating children’s experiences of stress and coping has utilised a quantitative approach. This study aimed to examine children’s experiences of stress by conducting interviews with children and their parents.Design: Dyadic child-parent interviews, embedded within a multiphase design. Methods: Thirty-eight children (22 boys) aged 7-11 years and 38 parents (34 mothers) completed in-depth dyadic interviews about stressful life events, adversity, and coping, analysed using inductive thematic analysis with a phenomenological lens. Results: Four themes emerged: 1. Navigating the social minefield; 2. Pressure to thrive in the modern world ; 3. Fear of the unknown; and 4. Learning life’s lessons. The first suggested that social relationships are a major feature of children’s stress experiences, however social support was also found to be a beneficial coping mechanism. The second theme highlighted multiple sources of pressure on young children (including school, extra-curricular activities, pressure from self and others); the impact of such pressure was dependent upon children’s coping resources. The third theme emphasised the difficulty of coping with novel stressors, and how awareness can help reduce this fear. The final theme highlighted important lessons that children can learn from stressful experiences and how to cope with stress.Conclusions: This study addresses the importance of the person and context-dependent nature of stress and coping in order for children to survive and thrive following stressful experiences. These findings contribute to existing knowledge that could be used to develop a toolkit for coping with stress, designed specifically for children, parents, schools and services.<br/
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