47,655 research outputs found
Numerical study of aerodynamic and aeroacoustic characteristics of flow over porous coated cylinders: Effects of porous properties
No full textThe aerodynamic and aeroacoustic performances of air over porous-coated cylinders are studied numerically with a new porous-fluid coupling method, which is based on k-ω turbulence model and implemented in the in-house compressible flow solver, aerodynamic and aeroacoustic investigation simulator (AAISIM). The turbulent boundary layer of the porous-fluid interface, which was commonly overlooked, is considered in the AAISIM. The permeable Ffowcs Williams and Hawkings (PFW-H) acoustic analogy is implemented and proved to be more accurate than the Ffowcs Williams and Hawkings (FW-H) method for porous-coated cylinder case. The porous coatings with pores per inch (PPI) ranging from 5 to 80 are considered in the present study. Lift and drag forces are collected from the inner cylinder wall surface, porous matrix, and the porous-fluid interface. Instead of monotonically increasing or decreasing, both the root-mean-square (RMS) lift coefficient and the aeolian noise achieve minimum values for the 10 PPI case, and the maximum total average drag coefficient is obtained for the 20 PPI case. The dead-zone length of the porous-coated cylinder is elongated than that of the solid case. The recirculating bubbles shift away from the inner cylinder surface to the interface. The turbulent kinetic energy increases near the porous-fluid interface as the number of PPI becomes larger
Barriers to help-seeking in the development of gaming disorder problems- Addendum 2023, April 18
No full textTang, K. T. Y., Belliveau, J., & Yakovenko, I. (2023, March 23). Barriers to help-seeking in the development of gaming disorder problems. Retrieved from: osf.io/khqc
T Cell responses to whole SARS Coronavirus in humans
Get PDFEffective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs. We conducted a cohort study examining multiple parameters of immune responses to SARS-CoV infection, aiming to identify the immune correlates of protection. We used a matrix of overlapping peptides spanning whole SARS-CoV proteome to determine T cell responses from 128 SARS convalescent samples by ex vivo IFN-γ ELISPOT assays. Approximately 50% of convalescent SARS patients were positive for T cell responses, and 90% possessed strongly neutralizing Abs. Fifty-five novel T cell epitopes were identified, with spike protein dominating total T cell responses. CD8+ T cell responses were more frequent and of a greater magnitude than CD4+ T cell responses (p < 0.001).
Polychromatic cytometry analysis indicated that the virus-specific T cells from the severe group tended to be a central memory phenotype (CD27+/CD45RO+) with a significantly higher frequency of polyfunctional CD4+ T cells producing IFN-γ, TNF-α, and IL-2, and CD8+ T cells producing IFN-γ, TNF-α, and CD107a (degranulation), as compared with the mild-moderate group. Strong T cell responses correlated significantly (p < 0.05) with higher neutralizing Ab. The serum cytokine profile during acute infection indicated a significant elevation of innate immune responses. Increased Th2 cytokines were observed in patients with fatal infection. Our study provides a roadmap for the immunogenicity of SARS-CoV and types of immune responses that may be responsible for the virus clearance, and should serve as a benchmark for SARS-CoV vaccine design and evaluation
Nuclear Proteins of the Bovine Esophageal Epithelium:II. the NuMA Gene Gives Rise to Multiple mRNAs and Gene Products Reactive with Monoclonal Antibody W1
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Erratum for “Protective effect of quercetin on bupivacaineinduced neurotoxicity via T-type calcium channel inhibition”
Get PDFJin et al Trop J Pharm Res 2017, 16(8): 1827-1833 http://dx.doi.org/10.4314/tjpr.v16i8.11The correct name of the First Author is Zhao as provided above and not Chao earlier published.Citation: Jin Z, Wu H, Tang C, Ke J, Wang Y. Protective effect of quercetin on bupivacaineinduced neurotoxicity via T-type calcium channel inhibition. Trop J Pharm Res 2017; 16(8):1827-1833 Erratum: 2017; 16(9):2051 http://dx.doi.org/10.4314/tjpr.v16i9.
Nuclear Mitotic Apparatus Protein (NuMA):Spindle Association, Nuclear Targeting and Differential Subcellular Localization of Various NuMA Isoforms
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